PMID- 37992989
OWN - NLM
STAT- MEDLINE
DCOM- 20240216
LR  - 20240216
IS  - 1876-4320 (Electronic)
IS  - 1874-9399 (Linking)
VI  - 1867
IP  - 1
DP  - 2024 Mar
TI  - Modulation of Kruppel-like factors (KLFs) interaction with their binding partners 
      in cancers through acetylation and phosphorylation.
PG  - 195003
LID - S1874-9399(23)00098-6 [pii]
LID - 10.1016/j.bbagrm.2023.195003 [doi]
AB  - Post-translational modifications (PTMs) of transcription factors regulate 
      transcriptional activity and play a key role in essentially all biological 
      processes and generate indispensable insight towards biological function 
      including activity state, subcellular localization, protein solubility, protein 
      folding, substrate trafficking, and protein-protein interactions. Amino acids 
      modified chemically via PTMs, function as molecular switches and affect the 
      protein function and characterization and increase the proteome complexity. 
      Kruppel-like transcription factors (KLFs) control essential cellular processes 
      including proliferation, differentiation, migration, programmed cell death and 
      various cancer-relevant processes. We investigated the interactions of KLF 
      group-2 members with their binding partners to assess the role of acetylation and 
      phosphorylation in KLFs on their binding affinity. It was observed that 
      acetylation and phosphorylation at different positions in KLFs have a variable 
      effect on binding with specific partners. KLF2-EP300, KLF4-SP1, KLF6-ATF3, 
      KLF6-JUN, and KLF7-JUN show stabilization upon acetylation or phosphorylation at 
      variable positions. On the other hand, KLF4-CBP, KLF4-EP300, KLF5-CBP, KLF5-WWP1, 
      KLF6-SP1, and KLF7-ATF3 show stabilization or destabilization due to acetylation 
      or phosphorylation at variable positions in KLFs. This provides a molecular 
      explanation of the experimentally observed dual role of KLF group-2 members as a 
      suppressor or activator of cancers in a PTM-dependent manner.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Jha, Kanupriya
AU  - Jha K
AD  - Department of Biotechnology, School of Engineering and Applied Sciences, Bennett 
      University, Plot Nos. 8-11, Tech Zone 2, Greater Noida, Uttar Pradesh 201310, 
      India. Electronic address: e20soe812@bennett.edu.in.
FAU - Kumar, Amit
AU  - Kumar A
AD  - Department of Biotechnology, School of Engineering and Applied Sciences, Bennett 
      University, Plot Nos. 8-11, Tech Zone 2, Greater Noida, Uttar Pradesh 201310, 
      India. Electronic address: e22soep0078@bennett.edu.in.
FAU - Bhatnagar, Kartik
AU  - Bhatnagar K
AD  - Department of Biotechnology, School of Engineering and Applied Sciences, Bennett 
      University, Plot Nos. 8-11, Tech Zone 2, Greater Noida, Uttar Pradesh 201310, 
      India. Electronic address: e22soep0047@bennett.edu.in.
FAU - Patra, Anupam
AU  - Patra A
AD  - Transcription Regulation Group, International Centre for Genetic Engineering and 
      Biotechnology (ICGEB), New Delhi 110067, India. Electronic address: 
      anupam@icgeb.res.in.
FAU - Bhavesh, Neel Sarovar
AU  - Bhavesh NS
AD  - Transcription Regulation Group, International Centre for Genetic Engineering and 
      Biotechnology (ICGEB), New Delhi 110067, India. Electronic address: 
      neelsb@icgeb.res.in.
FAU - Singh, Bipin
AU  - Singh B
AD  - Department of Biotechnology, School of Engineering and Applied Sciences, Bennett 
      University, Plot Nos. 8-11, Tech Zone 2, Greater Noida, Uttar Pradesh 201310, 
      India; Centre for Life Sciences, Mahindra University, Bahadurpally, Jeedimetla, 
      Hyderabad, Telangana 500043, India. Electronic address: 
      bipin.singh@mahindrauniversity.edu.in.
FAU - Chaudhary, Sarika
AU  - Chaudhary S
AD  - Department of Biotechnology, School of Engineering and Applied Sciences, Bennett 
      University, Plot Nos. 8-11, Tech Zone 2, Greater Noida, Uttar Pradesh 201310, 
      India. Electronic address: sarika.chaudhary@bennett.edu.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231120
PL  - Netherlands
TA  - Biochim Biophys Acta Gene Regul Mech
JT  - Biochimica et biophysica acta. Gene regulatory mechanisms
JID - 101731723
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - EC 2.3.2.26 (WWP1 protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - 0 (KLF7 protein, human)
SB  - IM
MH  - Humans
MH  - *Kruppel-Like Transcription Factors/genetics
MH  - Phosphorylation
MH  - Acetylation
MH  - Protein Processing, Post-Translational
MH  - *Neoplasms/genetics
MH  - Ubiquitin-Protein Ligases/metabolism
OTO - NOTNLM
OT  - Acetylation
OT  - Cancer
OT  - Kruppel-like transcription factors (KLFs)
OT  - Phosphorylation
OT  - Post-translational modification (PTM)
COIS- Declaration of competing interest The authors declare no competing interest.
EDAT- 2023/11/23 00:42
MHDA- 2024/02/16 06:43
CRDT- 2023/11/22 19:31
PHST- 2023/05/31 00:00 [received]
PHST- 2023/09/05 00:00 [revised]
PHST- 2023/11/16 00:00 [accepted]
PHST- 2024/02/16 06:43 [medline]
PHST- 2023/11/23 00:42 [pubmed]
PHST- 2023/11/22 19:31 [entrez]
AID - S1874-9399(23)00098-6 [pii]
AID - 10.1016/j.bbagrm.2023.195003 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Gene Regul Mech. 2024 Mar;1867(1):195003. doi: 
      10.1016/j.bbagrm.2023.195003. Epub 2023 Nov 20.