PMID- 37996206
OWN - NLM
STAT- MEDLINE
DCOM- 20240216
LR  - 20240216
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Linking)
VI  - 159
DP  - 2023
TI  - MHC cross-dressing in antigen presentation.
PG  - 115-147
LID - S0065-2776(23)00026-3 [pii]
LID - 10.1016/bs.ai.2023.07.001 [doi]
AB  - Dendritic cells (DCs) orchestrate T cell responses by presenting antigenic 
      peptides on major histocompatibility complex (MHC) and providing costimulation 
      and other instructive signals. Professional antigen presenting cells (APCs), 
      including DCs, are uniquely capable of generating and presenting peptide antigens 
      derived from exogenous proteins. In addition to these canonical 
      cross-presentation and MHC-II presentation pathways, APCs can also display 
      exogenous peptide/MHC (p/MHC) acquired from neighboring cells and extracellular 
      vesicles (EVs). This process, known as MHC cross-dressing, has been implicated in 
      the regulation of T cell responses in a variety of in vivo contexts, including 
      allogeneic solid organ transplantation, tumors, and viral infection. Although the 
      occurrence of MHC cross-dressing has been clearly demonstrated, the importance of 
      this antigen presentation mechanism continues to be elucidated. The contribution 
      of MHC cross-dressing to overall antigen presentation has been obfuscated by the 
      fact that DCs express the same MHC alleles as all other cells in the host, making 
      it difficult to distinguish p/MHC generated within the DC from p/MHC acquired 
      from another cell. As a result, much of what is known about MHC cross-dressing 
      comes from studies using allogeneic organ transplantation and bone marrow 
      chimeric mice, though recent development of mice bearing conditional knockout MHC 
      and beta2-microglobulin alleles should facilitate substantial progress in the coming 
      years. In this review, we highlight recent advances in our understanding of MHC 
      cross-dressing and its role in activating T cell responses in various contexts, 
      as well as the experimental insights into the mechanism by which it occurs.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - MacNabb, Brendan W
AU  - MacNabb BW
AD  - Division of Biology and Biological Engineering, California Institute of 
      Technology, Pasadena, CA, United States. Electronic address: 
      bmacnabb@caltech.edu.
FAU - Kline, Justin
AU  - Kline J
AD  - Department of Medicine, Committee on Immunology, and Committee on Cancer Biology, 
      University of Chicago, Chicago, IL, United States. Electronic address: 
      jkline@medicine.bsd.uchicago.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231104
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
RN  - 0 (Antigens)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Peptides)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Antigen Presentation
MH  - Antigens/metabolism
MH  - *Dendritic Cells
MH  - Histocompatibility Antigens/metabolism
MH  - Histocompatibility Antigens Class I/metabolism
MH  - Major Histocompatibility Complex
MH  - Peptides/metabolism
OTO - NOTNLM
OT  - Antigen presentation
OT  - MHC cross-dressing
EDAT- 2023/11/24 00:42
MHDA- 2023/11/27 12:44
CRDT- 2023/11/23 20:59
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/11/24 00:42 [pubmed]
PHST- 2023/11/23 20:59 [entrez]
AID - S0065-2776(23)00026-3 [pii]
AID - 10.1016/bs.ai.2023.07.001 [doi]
PST - ppublish
SO  - Adv Immunol. 2023;159:115-147. doi: 10.1016/bs.ai.2023.07.001. Epub 2023 Nov 4.