PMID- 37996267 OWN - NLM STAT- MEDLINE DCOM- 20240129 LR - 20240206 IS - 1424-3911 (Electronic) IS - 1424-3903 (Linking) VI - 24 IP - 1 DP - 2024 Feb TI - The relationship between observation interval and prognosis in pancreatic cancer concomitant with intraductal papillary mucinous neoplasia. PG - 73-77 LID - S1424-3903(23)01842-2 [pii] LID - 10.1016/j.pan.2023.11.005 [doi] AB - BACKGROUND: Intraductal papillary mucinous neoplasia (IPMN) is a risk factor for pancreatic cancer (PC). PC concomitant with IPMN shows rapid progression similar to de novo PC, therefore, the appropriate observation interval (OI) is not yet clear. PATIENTS AND METHOD: This was a multicenter retrospective observational study, and patients with PC concomitant with IPMN were analyzed. OI was defined as the interval between the date of imaging at PC diagnosis and just before the diagnosis. Clinical factors of PC and prognosis were assessed according to OI. RESULTS: From January 2010 to December 2018, 73 patients from 11 institutions were enrolled. The images performed just before PC diagnosis were contrast-enhanced CT/magnetic resonance imaging/endoscopic ultrasonography in 44/27/2 patients, respectively. The median cyst size was 14.0 mm, and the median main pancreatic duct diameter was 3.0 mm. The median OI was 6.8 months. In OI 6 months or less (OI 6 M), the mean tumor size, the frequencies of metastatic PC, resectable PC and early-stage PC were 20.1/21.5 mm (P = 0.91), 12.1 %/32.5 % (P = 0.05), 72.7 %/52.5 % (P = 0.09) and 27.3 %/25.0 % (P = 1.00), respectively. The median overall survival was 35.5 months in OI 6 M (P = 0.05). CONCLUSION: In OI 6 months or less, the rate of resectable PC was high, however, the rate of early PC was almost the same as that of OI more than 6 months. Approximately 10 % of cases found in the advanced stage with metastasis even if OI 6 months or less. CI - Copyright (c) 2023. Published by Elsevier B.V. FAU - Yoshioka, Teppei AU - Yoshioka T AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Shigekawa, Minoru AU - Shigekawa M AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Ikezawa, Kenji AU - Ikezawa K AD - Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan. FAU - Hirao, Motohiro AU - Hirao M AD - Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Osaka, Japan. FAU - Ishii, Shuji AU - Ishii S AD - Department of Gastroenterology and Hepatology, Osaka General Medical Center, Osaka, Japan. FAU - Suda, Takahiro AU - Suda T AD - Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan. FAU - Kegasawa, Tadashi AU - Kegasawa T AD - Department of Gastroenterology and Hepatology, Ikeda Municipal Hospital, Ikeda, Osaka, Japan. FAU - Matsumoto, Kengo AU - Matsumoto K AD - Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan. FAU - Iwahashi, Kiyoshi AU - Iwahashi K AD - Department of Gastroenterology and Hepatology, Osaka Police Hospital, Osaka, Osaka, Japan. FAU - Murata, Jun AU - Murata J AD - Department of Gastroenterology, Higashiosaka City Medical Center, Higashiosaka, Osaka, Japan. FAU - Kaneko, Akira AU - Kaneko A AD - Department of Gastroenterology and Hepatology, Minoh City Hospital, Minoh, Osaka, Japan. FAU - Nakazuru, Shoichi AU - Nakazuru S AD - Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan. FAU - Yamamoto, Shuhei AU - Yamamoto S AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Matsumae, Takayuki AU - Matsumae T AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Kozumi, Kazuhiro AU - Kozumi K AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Sato, Yu AU - Sato Y AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Okabe, Junya AU - Okabe J AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Sato, Katsuhiko AU - Sato K AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Hikita, Hayato AU - Hikita H AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Sakamori, Ryotaro AU - Sakamori R AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Tatsumi, Tomohide AU - Tatsumi T AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Takehara, Tetsuo AU - Takehara T AD - Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Electronic address: takehara@gh.med.osaka-u.ac.jp. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20231118 PL - Switzerland TA - Pancreatology JT - Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] JID - 100966936 SB - IM MH - Humans MH - *Carcinoma, Pancreatic Ductal/complications/diagnostic imaging/pathology MH - *Pancreatic Intraductal Neoplasms MH - *Adenocarcinoma, Mucinous/complications/diagnostic imaging/pathology MH - *Pancreatic Neoplasms/complications/diagnostic imaging MH - Prognosis MH - Retrospective Studies MH - Magnetic Resonance Imaging OTO - NOTNLM OT - Intraductal papillary mucinous neoplasia OT - Observation interval OT - Pancreatic cancer COIS- Declaration of competing interest There are no conflicts of interest to declare in this manuscript. EDAT- 2023/11/24 00:42 MHDA- 2024/01/29 06:42 CRDT- 2023/11/23 21:59 PHST- 2023/06/26 00:00 [received] PHST- 2023/10/24 00:00 [revised] PHST- 2023/11/08 00:00 [accepted] PHST- 2024/01/29 06:42 [medline] PHST- 2023/11/24 00:42 [pubmed] PHST- 2023/11/23 21:59 [entrez] AID - S1424-3903(23)01842-2 [pii] AID - 10.1016/j.pan.2023.11.005 [doi] PST - ppublish SO - Pancreatology. 2024 Feb;24(1):73-77. doi: 10.1016/j.pan.2023.11.005. Epub 2023 Nov 18.