PMID- 37997726
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 27
IP  - 11
DP  - 2023
TI  - Comparative Analysis of Intrinsic Capacity Impairments, Determinants, and 
      Clinical Consequences in Older Community-Dwellers in Japan and Taiwan: 
      Longitudinal Studies Showing Shared Traits and Distinct Presentations.
PG  - 1038-1046
LID - 10.1007/s12603-023-2020-z [doi]
AB  - OBJECTIVES: Despite the recognized impact of intrinsic capacity (IC) impairment 
      on healthy aging, international comparisons in different sociocultural contexts 
      are scarce. This study aimed to compare IC impairment among community-dwelling 
      older adults in Japan and Taiwan to explore the context of healthy aging in 
      different countries. DESIGN: Comparative observational study. SETTING: National 
      Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) in Japan 
      and Longitudinal Aging Study of Taipei (LAST) in Taiwan. PARTICIPANTS: 794 
      individuals (age range, 60.0-86.5 years) from NILS-LSA and 1,358 (60.0-96.7 
      years) from LAST. MEASUREMENTS: IC impairment was evaluated across the domains of 
      locomotion, cognition, vitality, sensory capacity, and psychological well-being. 
      Participants were categorized as having impaired IC or healthy. We investigated 
      associations between IC impairment, falls, and all-cause mortality. RESULTS: IC 
      impairment was present in 54.9% and 37.3% of participants in the NILS-LSA and 
      LAST cohorts, respectively. Male NILS-LSA participants with impaired IC (odds 
      ratio [OR]:1.50, 95% confidence interval [CI]:1.03-2.20), with hearing loss 
      (OR:1.98, 95% CI:1.00-3.90) were more likely to fall. In LAST, impaired 
      locomotion (OR:2.14, 95% CI:1.46-3.14) increased the risk of falls. Men with 
      impaired IC (hazard ratio [HR]; 2.14, 95% CI:1.10-4.15) and visual impairment 
      (HR:2.21, 95% CI:1.15-4.25) and women with impaired psychological well-being 
      (HR:4.94, 95% CI:1.28-18.97) in the NILS-LSA cohort had greater risk for 
      all-cause mortality; however, this was not shown for LAST participants. 
      CONCLUSION: The prevalence and distribution of IC impairment and associated 
      biomarkers differed significantly between participants in Japan and Taiwan. 
      However, the associations with adverse outcomes remained similar, emphasizing the 
      need for tailored interventions for healthy aging.
FAU - Zhang, S
AU  - Zhang S
AD  - Liang-Kung Chen, MD, PhD, Center for Geriatrics and Gerontology, Taipei Veterans 
      General Hospital, No. 201, Sec 2, Shih-Pai Road, Taipei, Taiwan 11217, Email: 
      lkchen2@vghtpe.gov.tw, Tel: +886-2-28757830, Fax: +886-2-28757711.
FAU - Peng, L-N
AU  - Peng LN
FAU - Otsuka, R
AU  - Otsuka R
FAU - Liang, C-K
AU  - Liang CK
FAU - Nishita, Y
AU  - Nishita Y
FAU - Arai, H
AU  - Arai H
FAU - Chen, L-K
AU  - Chen LK
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Aged
MH  - Aged, 80 and over
MH  - Longitudinal Studies
MH  - Japan/epidemiology
MH  - Taiwan/epidemiology
MH  - *Aging
MH  - *Longevity
OTO - NOTNLM
OT  - Intrinsic capacity
OT  - Japan
OT  - Taiwan
OT  - community-dwelling older individuals
OT  - healthy aging
COIS- None.
EDAT- 2023/11/24 06:42
MHDA- 2023/11/27 12:45
CRDT- 2023/11/24 05:29
PHST- 2023/11/27 12:45 [medline]
PHST- 2023/11/24 06:42 [pubmed]
PHST- 2023/11/24 05:29 [entrez]
AID - S1279-7707(23)02615-5 [pii]
AID - 10.1007/s12603-023-2020-z [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2023;27(11):1038-1046. doi: 10.1007/s12603-023-2020-z.