PMID- 37997735
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 27
IP  - 11
DP  - 2023
TI  - Plasma Inflammatory Biomarkers and Anorexia of Ageing among Community-Dwelling 
      Older Adults: An Exploratory Analysis of the MAPT Study.
PG  - 1127-1131
LID - 10.1007/s12603-023-2024-8 [doi]
AB  - Anorexia of aging and biological aging might share physiological underpinnings. 
      The aim of this secondary analysis was to investigate the associations between 
      circulating inflammation-related markers and anorexia of aging in 
      community-dwelling older adults. C-reactive protein (CRP), tumor necrosis factor 
      receptor-1 (TNFR-1), interleukin-6 (IL-6), monocyte chemoattractant protein-1 
      (MCP-1) and growth/differentiation factor-15 (GDF-15) were measured in plasma. 
      Anorexia of aging was defined by the response "severe/moderate decrease in food 
      intake" to the first item of the Mini-Nutritional Assessment. We included 463 
      subjects (median age=74y, IQR=71-78; 63.1% women). 33 subjects (7.1%) presented 
      with anorexia at baseline, whereas 25 out of 363 (6.9%) developed it along 1-year 
      follow-up. We found that TNFR1 (OR=1.74, 95%CI=1.27-2.39) and GDF-15 (OR=1.38, 
      95%CI=1.01-1.89) were associated with a significant increase in the odds of 
      presenting with anorexia of aging cross-sectionally. No further significant 
      associations were found. Biological aging mechanisms might be involved in the 
      pathogenesis of anorexia of aging.
FAU - Sanchez-Sanchez, J L
AU  - Sanchez-Sanchez JL
AD  - Juan Luis Sanchez-Sanchez, CHU Toulouse Gerontopole: Centre Hospitalier 
      Universitaire de Toulouse Gerontopole, France, jl.sanchezs@hotmail.com.
FAU - Guyonnet, S
AU  - Guyonnet S
FAU - Lucas, A
AU  - Lucas A
FAU - Parini, A
AU  - Parini A
FAU - Rolland, Y
AU  - Rolland Y
FAU - de Souto Barreto, P
AU  - de Souto Barreto P
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
RN  - 0 (Growth Differentiation Factor 15)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Female
MH  - Aged
MH  - Male
MH  - *Anorexia
MH  - *Independent Living
MH  - Growth Differentiation Factor 15
MH  - Aging/physiology
MH  - Biomarkers
OTO - NOTNLM
OT  - Biomarkers
OT  - anorexia of aging
OT  - inflammation
OT  - malnutrition
COIS- The authors declare the absence of conflicts of interest.
EDAT- 2023/11/24 06:43
MHDA- 2023/11/27 12:43
CRDT- 2023/11/24 05:29
PHST- 2023/11/27 12:43 [medline]
PHST- 2023/11/24 06:43 [pubmed]
PHST- 2023/11/24 05:29 [entrez]
AID - S1279-7707(23)02624-6 [pii]
AID - 10.1007/s12603-023-2024-8 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2023;27(11):1127-1131. doi: 10.1007/s12603-023-2024-8.