PMID- 37997787
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 14
IP  - 24
DP  - 2023 Dec 11
TI  - Effects of Fu brick tea polysaccharides on gut microbiota and fecal metabolites 
      of HFD/STZ-induced type 2 diabetes rats.
PG  - 10910-10923
LID - 10.1039/d3fo04215d [doi]
AB  - The prevalence of type 2 diabetes mellitus (T2DM) has dramatically increased 
      globally, and the antidiabetic effects and underlying mechanisms of the 
      polysaccharides extracted from Fu brick tea (FBTP) were investigated in high-fat 
      diet (HFD)/streptozotocin (STZ)-induced T2DM rats. Administration of FBTP at 200 
      and 400 mg per kg bw significantly relieved dyslipidemia (i.e. TC, TG, LDL-C and 
      HDL-C), insulin resistance (IR) and pancreas oxidative stress (i.e. CAT and 
      GSH-Px) in T2DM rats. Mechanistically, FBTP rescued the HFD/STZ-induced 
      alterations in the abundance of Bacteroidota, Actinobacteriota, Proteobacteria 
      and Firmicutes. At the genus level, FBTP notably increased the abundance of 
      Ruminococcus, Lactobacillus and Lachnospiraece_NK4A136_group, but reduced the 
      population of Prevotella and Faecalibaculum in T2DM rats. FBTP also significantly 
      elevated colonic short-chain fatty acid (SCFAs) levels. Moreover, apparent 
      changes in amino acid absorption and metabolism were observed upon FBTP 
      intervention. These findings suggested that FBTP might alleviate T2DM by 
      reshaping the gut microbiota and regulating intestinal metabolites.
FAU - Zhang, Xiangnan
AU  - Zhang X
AD  - Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and 
      Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of 
      Agricultural Products, College of Food Engineering and Nutritional Science, 
      Shaanxi Normal University, Xi'an 710119, China. xbyang@snnu.edu.cn.
FAU - Li, Qiannan
AU  - Li Q
AD  - Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and 
      Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of 
      Agricultural Products, College of Food Engineering and Nutritional Science, 
      Shaanxi Normal University, Xi'an 710119, China. xbyang@snnu.edu.cn.
FAU - Han, Ning
AU  - Han N
AD  - Key Laboratory of Ministry of Education for Medicinal Resource and Natural 
      Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, 
      Xi'an 710119, China.
FAU - Song, Chaofan
AU  - Song C
AD  - Key Laboratory of Ministry of Education for Medicinal Resource and Natural 
      Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, 
      Xi'an 710119, China.
FAU - Lin, Yangnan
AU  - Lin Y
AD  - Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and 
      Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of 
      Agricultural Products, College of Food Engineering and Nutritional Science, 
      Shaanxi Normal University, Xi'an 710119, China. xbyang@snnu.edu.cn.
FAU - Zhang, Liansheng
AU  - Zhang L
AD  - Key Laboratory of Ministry of Education for Medicinal Resource and Natural 
      Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, 
      Xi'an 710119, China.
FAU - Ren, Daoyuan
AU  - Ren D
AUID- ORCID: 0000-0001-9739-7611
AD  - Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and 
      Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of 
      Agricultural Products, College of Food Engineering and Nutritional Science, 
      Shaanxi Normal University, Xi'an 710119, China. xbyang@snnu.edu.cn.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - Key Laboratory of Ministry of Education for Medicinal Resource and Natural 
      Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, 
      Xi'an 710119, China.
FAU - Yang, Xingbin
AU  - Yang X
AUID- ORCID: 0000-0002-8039-0525
AD  - Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and 
      Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of 
      Agricultural Products, College of Food Engineering and Nutritional Science, 
      Shaanxi Normal University, Xi'an 710119, China. xbyang@snnu.edu.cn.
FAU - Li, Ting
AU  - Li T
AD  - Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and 
      Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of 
      Agricultural Products, College of Food Engineering and Nutritional Science, 
      Shaanxi Normal University, Xi'an 710119, China. xbyang@snnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231211
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 5W494URQ81 (Streptozocin)
RN  - 0 (Tea)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/drug therapy/metabolism
MH  - Streptozocin
MH  - Diet, High-Fat/adverse effects
MH  - *Gastrointestinal Microbiome
MH  - Tea
MH  - Polysaccharides/pharmacology
EDAT- 2023/11/24 12:42
MHDA- 2023/12/17 09:42
CRDT- 2023/11/24 06:43
PHST- 2023/12/17 09:42 [medline]
PHST- 2023/11/24 12:42 [pubmed]
PHST- 2023/11/24 06:43 [entrez]
AID - 10.1039/d3fo04215d [doi]
PST - epublish
SO  - Food Funct. 2023 Dec 11;14(24):10910-10923. doi: 10.1039/d3fo04215d.