PMID- 37999557
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231127
IS  - 2305-6304 (Electronic)
IS  - 2305-6304 (Linking)
VI  - 11
IP  - 11
DP  - 2023 Nov 6
TI  - Association between Urinary BPA Substitutes and Precocious Puberty among Girls: A 
      Single-Exposure and Mixed Exposure Approach from a Chinese Case-Control Study.
LID - 10.3390/toxics11110905 [doi]
LID - 905
AB  - There is an argument that BPA substitutes may have the same or more deleterious 
      health effects as BPA due to their structural similarity. This study explored the 
      association between urinary BPA substitutes and precocious puberty among girls by 
      including 120 girls with precocious puberty (cases) aged 2-10 years enrolled at 
      Nanjing Children's Hospital Department of Endocrinology in China between April 
      2021 to September 2021 and 145 healthy girls (controls) recruited from a primary 
      school. Logistic regression was used to evaluate the effect of single exposures, 
      and Bayesian kernel machine regression (BKMR) and quantile-based g-computation 
      were used for the mixed effect. In the multivariate logistic regression, BPS 
      (bisphenol S), TBBPA (tetrabromobisphenol A), and BPFL (bisphenol-FL) were 
      significantly associated with increased risk of precocious puberty (odds ratio 
      (OR) = 1.75, 95% confidence interval (CI): 1.13, 2.76, p = 0.014), (OR = 1.46, 
      CI: 1.06, 2.05; p = 0.023), and (OR = 1.47, CI: 1.01, 2.18; p = 0.047), 
      respectively. The BMKR and quantile-based g-computation models revealed 
      consistent associations for single exposures and there was insufficient evidence 
      for the associations of the mixed exposure of bisphenols with precocious puberty. 
      In conclusion, BPA substitutes such as BPS, TBBPA, and BPFL may be associated 
      with an increased risk of precocious puberty in girls.
FAU - Bigambo, Francis Manyori
AU  - Bigambo FM
AD  - Department of Endocrinology, Children's Hospital of Nanjing Medical University, 
      Nanjing 210008, China.
FAU - Wang, Dandan
AU  - Wang D
AD  - Department of Endocrinology, Children's Hospital of Nanjing Medical University, 
      Nanjing 210008, China.
FAU - Sun, Jian
AU  - Sun J
AD  - Department of Emergency, Pediatric Intensive Care Unit, Children's Hospital of 
      Nanjing Medical University, Nanjing 210008, China.
FAU - Ding, Xinliang
AU  - Ding X
AD  - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public 
      Health, Nanjing Medical University, Nanjing 211166, China.
AD  - Wuxi Center for Disease Control and Prevention, The Affiliated Wuxi Center for 
      Disease Control and Prevention, Nanjing Medical University, Wuxi 214023, China.
AD  - Research Base for Environment and Health in Wuxi, Chinese Center for Disease 
      Control and Prevention, Wuxi 214023, China.
FAU - Li, Xiuzhu
AU  - Li X
AD  - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public 
      Health, Nanjing Medical University, Nanjing 211166, China.
AD  - Wuxi Center for Disease Control and Prevention, The Affiliated Wuxi Center for 
      Disease Control and Prevention, Nanjing Medical University, Wuxi 214023, China.
AD  - Research Base for Environment and Health in Wuxi, Chinese Center for Disease 
      Control and Prevention, Wuxi 214023, China.
FAU - Gao, Beibei
AU  - Gao B
AD  - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public 
      Health, Nanjing Medical University, Nanjing 211166, China.
AD  - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of 
      Public Health, Nanjing Medical University, Nanjing 211166, China.
FAU - Wu, Di
AU  - Wu D
AD  - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public 
      Health, Nanjing Medical University, Nanjing 211166, China.
AD  - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of 
      Public Health, Nanjing Medical University, Nanjing 211166, China.
FAU - Gu, Wei
AU  - Gu W
AD  - Department of Endocrinology, Children's Hospital of Nanjing Medical University, 
      Nanjing 210008, China.
FAU - Zhang, Mingzhi
AU  - Zhang M
AD  - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public 
      Health, Nanjing Medical University, Nanjing 211166, China.
AD  - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of 
      Public Health, Nanjing Medical University, Nanjing 211166, China.
FAU - Wang, Xu
AU  - Wang X
AD  - Department of Endocrinology, Children's Hospital of Nanjing Medical University, 
      Nanjing 210008, China.
LA  - eng
GR  - 2022T150333/The National post-doctoral special research grants/
PT  - Journal Article
DEP - 20231106
PL  - Switzerland
TA  - Toxics
JT  - Toxics
JID - 101639637
PMC - PMC10675366
OTO - NOTNLM
OT  - BPA substitutes
OT  - case-control study
OT  - mixed exposure
OT  - precocious puberty
OT  - single exposure
COIS- The authors declare that they have no known competing financial interest or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/11/24 12:42
MHDA- 2023/11/24 12:43
PMCR- 2023/11/06
CRDT- 2023/11/24 09:54
PHST- 2023/10/09 00:00 [received]
PHST- 2023/10/27 00:00 [revised]
PHST- 2023/11/03 00:00 [accepted]
PHST- 2023/11/24 12:43 [medline]
PHST- 2023/11/24 12:42 [pubmed]
PHST- 2023/11/24 09:54 [entrez]
PHST- 2023/11/06 00:00 [pmc-release]
AID - toxics11110905 [pii]
AID - toxics-11-00905 [pii]
AID - 10.3390/toxics11110905 [doi]
PST - epublish
SO  - Toxics. 2023 Nov 6;11(11):905. doi: 10.3390/toxics11110905.