PMID- 38000460
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 182
DP  - 2023 Dec
TI  - Functional polymorphisms in Benzo(a)Pyrene-induced toxicity pathways associated 
      with the risk on laryngeal squamous cell carcinoma.
PG  - 114199
LID - S0278-6915(23)00601-4 [pii]
LID - 10.1016/j.fct.2023.114199 [doi]
AB  - Benzo(a)Pyrene (BaP) is a well-known environmental carcinogen that poses a 
      significant risk to human health. The pivotal genes and toxicity pathways have 
      been identified as key events to construct the mode of action (MOA) of BaP. In 
      this study, we focused on evaluating the association between genetic variants in 
      BaP-disturbed toxicity pathways and the susceptibility of laryngeal squamous cell 
      carcinoma (LSCC), based on the data of our previous genome-wide association 
      analysis (GWAS). In addition, we investigated the biological roles of these 
      significant polymorphisms by integrating bioinformatic annotation and 
      experimental validation. Our findings revealed that 15 functional polymorphisms 
      in AHR signaling, p53 signaling, NRF2 signaling, TGF-beta signaling, STAT3 
      signaling, and IL-8 signaling pathways were significantly associated with 
      susceptibility to LSCC. Our study provides a novel approach for identifying novel 
      risk genetic loci utilizing GWAS data, and suggests potential targets for early 
      detection of LSCC in the future.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Xu, Lin
AU  - Xu L
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Sun, Xueying
AU  - Sun X
AD  - School of Public Health, Qingdao University, Qingdao, China; Weifang Municipal 
      Center for Disease Control and Prevention, Weifang, Shandong, China.
FAU - Wang, Yiyi
AU  - Wang Y
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Zhou, Tao
AU  - Zhou T
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Jia, Jingjing
AU  - Jia J
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Zhang, Mai
AU  - Zhang M
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Zhou, Pengyuan
AU  - Zhou P
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Wang, Yixiao
AU  - Wang Y
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Wang, Youshuo
AU  - Wang Y
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Shou, Yingqing
AU  - Shou Y
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Huo, Xiaoyu
AU  - Huo X
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Ji, Xiaoying
AU  - Ji X
AD  - School of Public Health, Qingdao University, Qingdao, China.
FAU - Chen, Jing
AU  - Chen J
AD  - School of Public Health, Qingdao University, Qingdao, China. Electronic address: 
      chen.jing@qdu.edu.cn.
FAU - Yu, Dianke
AU  - Yu D
AD  - School of Public Health, Qingdao University, Qingdao, China.
LA  - eng
PT  - Journal Article
DEP - 20231123
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 3417WMA06D (Benzo(a)pyrene)
SB  - IM
MH  - Humans
MH  - *Benzo(a)pyrene/metabolism
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Genome-Wide Association Study
MH  - Polymorphism, Genetic
MH  - *Head and Neck Neoplasms
OTO - NOTNLM
OT  - Benzo(a)Pyrene
OT  - Laryngeal squamous cell carcinoma
OT  - Single nucleotide polymorphism
OT  - Toxicity pathway
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/25 07:42
MHDA- 2023/12/17 13:19
CRDT- 2023/11/24 19:25
PHST- 2023/09/10 00:00 [received]
PHST- 2023/10/30 00:00 [revised]
PHST- 2023/11/17 00:00 [accepted]
PHST- 2023/12/17 13:19 [medline]
PHST- 2023/11/25 07:42 [pubmed]
PHST- 2023/11/24 19:25 [entrez]
AID - S0278-6915(23)00601-4 [pii]
AID - 10.1016/j.fct.2023.114199 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2023 Dec;182:114199. doi: 10.1016/j.fct.2023.114199. Epub 2023 
      Nov 23.