PMID- 38001574
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 22
DP  - 2023 Nov 7
TI  - Moving the Needle Forward in Genomically-Guided Precision Radiation Treatment.
LID - 10.3390/cancers15225314 [doi]
LID - 5314
AB  - Radiation treatment (RT) is a mainstay treatment for many types of cancer. 
      Recommendations for RT and the radiation plan are individualized to each patient, 
      taking into consideration the patient's tumor pathology, staging, anatomy, and 
      other clinical characteristics. Information on germline mutations and somatic 
      tumor mutations is at present rarely used to guide specific clinical decisions in 
      RT. Many genes, such as ATM, and BRCA1/2, have been identified in the laboratory 
      to confer radiation sensitivity. However, our understanding of the clinical 
      significance of mutations in these genes remains limited and, as individual 
      mutations in such genes can be rare, their impact on tumor response and toxicity 
      remains unclear. Current guidelines, including those from the National 
      Comprehensive Cancer Network (NCCN), provide limited guidance on how genetic 
      results should be integrated into RT recommendations. With an increasing 
      understanding of the molecular underpinning of radiation response, 
      genomically-guided RT can inform decisions surrounding RT dose, volume, 
      concurrent therapies, and even omission to further improve oncologic outcomes and 
      reduce risks of toxicities. Here, we review existing evidence from laboratory, 
      pre-clinical, and clinical studies with regard to how genetic alterations may 
      affect radiosensitivity. We also summarize recent data from clinical trials and 
      explore potential future directions to utilize genetic data to support clinical 
      decision-making in developing a pathway toward personalized RT.
FAU - Tam, Andrew
AU  - Tam A
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
FAU - Mercier, Benjamin D
AU  - Mercier BD
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
AD  - Department of Medical Oncology & Therapeutics Research, City of Hope 
      Comprehensive Cancer Center, 1500 E Duarte Rd., Duarte, CA 91010, USA.
FAU - Thomas, Reeny M
AU  - Thomas RM
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
FAU - Tizpa, Eemon
AU  - Tizpa E
AUID- ORCID: 0000-0002-9349-7962
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
FAU - Wong, Irene G
AU  - Wong IG
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
FAU - Shi, Juncong
AU  - Shi J
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
FAU - Garg, Rishabh
AU  - Garg R
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
FAU - Hampel, Heather
AU  - Hampel H
AD  - Department of Medical Oncology & Therapeutics Research, City of Hope 
      Comprehensive Cancer Center, 1500 E Duarte Rd., Duarte, CA 91010, USA.
FAU - Gray, Stacy W
AU  - Gray SW
AD  - Department of Medical Oncology & Therapeutics Research, City of Hope 
      Comprehensive Cancer Center, 1500 E Duarte Rd., Duarte, CA 91010, USA.
FAU - Williams, Terence
AU  - Williams T
AUID- ORCID: 0000-0002-1020-0845
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
FAU - Bazan, Jose G
AU  - Bazan JG
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
FAU - Li, Yun R
AU  - Li YR
AUID- ORCID: 0000-0002-8077-4975
AD  - Department of Radiation Oncology, City of Hope Comprehensive Cancer Center, 1500 
      E Duarte Rd., Duarte, CA 91010, USA.
AD  - Department of Cancer Genetics and Epigenetics, City of Hope National Medical 
      Center, Duarte, CA 91010, USA.
AD  - Division of Quantitative Medicine & Systems Biology, Translational Genomics 
      Research Institute, 445 N. Fifth Street, Phoenix, AZ 85022, USA.
LA  - eng
GR  - DP5 OD033424/OD/NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20231107
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10669735
OTO - NOTNLM
OT  - DNA
OT  - cancer
OT  - genes
OT  - germline
OT  - mutations
OT  - oncology
OT  - radiation sensitivity
OT  - radiation treatment
OT  - radiogenomics
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:43
MHDA- 2023/11/25 12:44
PMCR- 2023/11/07
CRDT- 2023/11/25 01:05
PHST- 2023/07/12 00:00 [received]
PHST- 2023/10/06 00:00 [revised]
PHST- 2023/10/13 00:00 [accepted]
PHST- 2023/11/25 12:44 [medline]
PHST- 2023/11/25 12:43 [pubmed]
PHST- 2023/11/25 01:05 [entrez]
PHST- 2023/11/07 00:00 [pmc-release]
AID - cancers15225314 [pii]
AID - cancers-15-05314 [pii]
AID - 10.3390/cancers15225314 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Nov 7;15(22):5314. doi: 10.3390/cancers15225314.