PMID- 38001720
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231127
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 22
DP  - 2023 Nov 17
TI  - The Diagnostic and Predictive Value of (18)F-Fluorodeoxyglucose Positron Emission 
      Tomography/Computed Tomography in Laryngeal Squamous Cell Carcinoma.
LID - 10.3390/cancers15225461 [doi]
LID - 5461
AB  - This retrospective study examines the diagnostic accuracy of 
      (18)F-fluorodeoxyglucose positron emission tomography/computed tomography 
      ((18)F-FDG PET/CT) and neck magnetic resonance imaging (MRI) in detecting nodal 
      metastasis for patients with laryngeal squamous cell carcinoma (LSCC) and 
      assesses the predictive values of metabolic and structural features derived from 
      (18)F-FDG PET/CT. By involving 66 patients from 2014 to 2021, the sensitivity and 
      specificity of both modalities were calculated. (18)F-FDG PET/CT outperforms neck 
      MRI for nodal disease detection, with 89% sensitivity, 65% specificity, and 77% 
      accuracy for nodal metastasis (p = 0.03). On the other hand, neck MRI had 66% 
      sensitivity, 62% specificity, and 64% accuracy. Approximately 11% of patients 
      witnessed a change in their therapy intent when relying on (18)F-FDG PET/CT nodal 
      staging results. Analyzing the cohort for PET-derived metabolic and morphological 
      parameters, a total of 167 lymph nodes (LN) were visualized. Parameters such as 
      the LN maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), 
      total lesion glycolysis (TLG), and LN size were computed. Logistic regression and 
      receiver operating characteristic (ROC) analyses were performed. Among the 167 
      identified cervical LNs, 111 were histopathologically confirmed as positive. ROC 
      analysis revealed the highest area under the curve for LN MTV (0.89; p < 0.01), 
      followed by LN size (0.87; p < 0.01). Both MTV and LN size independently 
      predicted LN metastasis through multivariate analysis. In addition, LN MTV can 
      reliably predict false-positive LNs in preoperative staging, offering a promising 
      imaging-based approach for further exploration.
FAU - Al-Ibraheem, Akram
AU  - Al-Ibraheem A
AUID- ORCID: 0000-0002-0978-4716
AD  - Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), 
      Amman 11941, Jordan.
AD  - School of Medicine, University of Jordan, Amman 11942, Jordan.
FAU - Abdlkadir, Ahmed Saad
AU  - Abdlkadir AS
AUID- ORCID: 0000-0002-2009-5110
AD  - Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), 
      Amman 11941, Jordan.
FAU - Shagera, Qaid Ahmed
AU  - Shagera QA
AD  - Nuclear Medicine Department, Institut Jules Bordet, Erasme Hospital, Hopital 
      Universitaire de Bruxelles, Universite Libre de Bruxelles, 1070 Brussels, 
      Belgium.
FAU - Saraireh, Omar
AU  - Saraireh O
AD  - Department of Surgical Oncology, King Hussein Cancer Center (KHCC), Amman 11941, 
      Jordan.
FAU - Al-Adhami, Dhuha
AU  - Al-Adhami D
AD  - Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), 
      Amman 11941, Jordan.
FAU - Al-Rashdan, Rakan
AU  - Al-Rashdan R
AD  - Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), 
      Amman 11941, Jordan.
FAU - Anwar, Farah
AU  - Anwar F
AD  - Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), 
      Amman 11941, Jordan.
AD  - Department of Nuclear Medicine, Warith International Cancer Institute, Karbala 
      56001, Iraq.
FAU - Moghrabi, Serin
AU  - Moghrabi S
AD  - Department of Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), 
      Amman 11941, Jordan.
FAU - Mohamad, Issa
AU  - Mohamad I
AUID- ORCID: 0000-0003-0153-9131
AD  - Department of Radiation Oncology, King Hussein Cancer Center (KHCC), Amman 11941, 
      Jordan.
FAU - Muylle, Kristoff
AU  - Muylle K
AD  - Department of Nuclear Medicine, AZ Delta, 8800 Roeselare, Belgium.
FAU - Estrada, Enrique
AU  - Estrada E
AD  - Nuclear Medicine and Diagnostic Imaging Section, Department of Nuclear Sciences 
      and Applications, International Atomic Energy Agency (IAEA), 6CM8+ Vienna, 
      Austria.
FAU - Paez, Diana
AU  - Paez D
AD  - Nuclear Medicine and Diagnostic Imaging Section, Department of Nuclear Sciences 
      and Applications, International Atomic Energy Agency (IAEA), 6CM8+ Vienna, 
      Austria.
FAU - Mansour, Asem
AU  - Mansour A
AD  - Department of Diagnostic Radiology, King Hussein Cancer Center (KHCC), Amman 
      11941, Jordan.
FAU - Lopci, Egesta
AU  - Lopci E
AUID- ORCID: 0000-0001-9732-1094
AD  - Nuclear Medicine Unit, IRCCS, Humanitas Clinical and Research Hospital, Via 
      Manzoni56, 20089 Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20231117
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10670341
OTO - NOTNLM
OT  - FDG PET/CT
OT  - MTV
OT  - TLG
OT  - laryngeal neoplasms
OT  - lymph nodes
OT  - lymphatic metastasis
OT  - squamous cell carcinoma
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:43
MHDA- 2023/11/25 12:44
PMCR- 2023/11/17
CRDT- 2023/11/25 01:06
PHST- 2023/10/25 00:00 [received]
PHST- 2023/11/11 00:00 [revised]
PHST- 2023/11/16 00:00 [accepted]
PHST- 2023/11/25 12:44 [medline]
PHST- 2023/11/25 12:43 [pubmed]
PHST- 2023/11/25 01:06 [entrez]
PHST- 2023/11/17 00:00 [pmc-release]
AID - cancers15225461 [pii]
AID - cancers-15-05461 [pii]
AID - 10.3390/cancers15225461 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Nov 17;15(22):5461. doi: 10.3390/cancers15225461.