PMID- 38001809
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231128
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 12
IP  - 11
DP  - 2023 Nov 2
TI  - Ramon Flour (Brosimum alicastrum Swartz) Ameliorates Hepatic Lipid Accumulation, 
      Induction of AMPK Phosphorylation, and Expression of the Hepatic Antioxidant 
      System in a High-Fat-Diet-Induced Obesity Mouse Model.
LID - 10.3390/antiox12111957 [doi]
LID - 1957
AB  - Excessive consumption of fat and carbohydrates, together with a decrease in 
      traditional food intake, has been related to obesity and the development of 
      metabolic alterations. Ramon seed is a traditional Mayan food used to obtain 
      Ramon flour (RF) with high biological value in terms of protein, fiber, 
      micronutrients, and bioactive compounds such as polyphenols. However, few studies 
      have evaluated the beneficial effects of RF. Thus, we aimed to determine the 
      metabolic effects of RF consumption on a high-fat-diet-induced obesity mouse 
      model. We divided male BALB/c mice into four groups (n = 5 each group) and fed 
      them for 90 days with the following diets: Control (C): control diet (AIN-93), C 
      + RF: control diet adjusted with 25% RF, HFD: high-fat diet + 5% sugar in water, 
      and HFD + RF: high-fat diet adjusted with 25% RF + 5% sugar in water. The RF 
      prevented the increase in serum total cholesterol (TC) and alanine transaminase 
      (ALT) that occurred in the C and HFD groups. Notably, RF together with HFD 
      increased serum polyphenols and antioxidant activity, and it promoted a decrease 
      in the adipocyte size in white adipose tissue, along with lower hepatic lipid 
      accumulation than in the HFD group. In the liver, the HFD + RF group showed an 
      increase in the expression of beta-oxidation-related genes, and downregulation of 
      the fatty acid synthase (Fas) gene compared with the HFD group. Moreover, the HFD 
      + RF group had increased hepatic phosphorylation of AMP-activated protein kinase 
      (AMPK), along with increased nuclear factor erythroid 2-related factor 2 (NRF2) 
      and superoxide dismutase 2 (SOD2) protein expression compared with the HFD group. 
      Thus, RF may be used as a nutritional strategy to decrease metabolic alterations 
      during obesity.
FAU - Cu-Canetas, Trinidad Eugenia
AU  - Cu-Canetas TE
AD  - Escuela de Salud, Universidad Modelo, Merida 97130, Yucatan, Mexico.
FAU - Velazquez-Villegas, Laura A
AU  - Velazquez-Villegas LA
AUID- ORCID: 0000-0002-5310-5637
AD  - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
FAU - Manzanilla-Franco, Mariana
AU  - Manzanilla-Franco M
AD  - Escuela de Salud, Universidad Modelo, Merida 97130, Yucatan, Mexico.
FAU - Ayora-Talavera, Teresa Del Rosario
AU  - Ayora-Talavera TDR
AUID- ORCID: 0000-0003-2469-3238
AD  - Centro de Investigacion y Asistencia en Tecnologia y Diseno del Estado de Jalisco 
      (CIATEJ) A.C., Subsede Sureste, Merida 97302, Yucatan, Mexico.
FAU - Acevedo-Fernandez, Juan Jose
AU  - Acevedo-Fernandez JJ
AUID- ORCID: 0000-0001-8306-1690
AD  - Departamento de Fisiologia y Fisiopatologia, Facultad de Medicina, Universidad 
      Autonoma del Estado de Morelos (UAEM), Cuernavaca 62350, Morelos, Mexico.
FAU - Barbosa-Martin, Enrique
AU  - Barbosa-Martin E
AUID- ORCID: 0000-0003-0247-0957
AD  - Escuela de Salud, Universidad Modelo, Merida 97130, Yucatan, Mexico.
FAU - Marquez-Mota, Claudia C
AU  - Marquez-Mota CC
AUID- ORCID: 0000-0002-4311-381X
AD  - Departamento de Nutricion Animal y Bioquimica, Facultad de Medicina Veterinaria y 
      Zootecnia, Universidad Nacional Autonoma de Mexico (FMVZ-UNAM), Ciudad de Mexico 
      04510, Mexico.
FAU - Lopez-Barradas, Adriana M
AU  - Lopez-Barradas AM
AD  - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
FAU - Noriega, Lilia G
AU  - Noriega LG
AUID- ORCID: 0000-0003-2156-9872
AD  - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
FAU - Guevara-Cruz, Martha
AU  - Guevara-Cruz M
AUID- ORCID: 0000-0002-8996-3481
AD  - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias 
      Medicas y Nutricion Salvador Zubiran (INCMNSZ), Ciudad de Mexico 14080, Mexico.
FAU - Gutierrez-Solis, Ana Ligia
AU  - Gutierrez-Solis AL
AUID- ORCID: 0000-0002-4302-4753
AD  - Hospital Regional de Alta Especialidad de la Peninsula de Yucatan (HRAEPY), 
      Merida 97130, Yucatan, Mexico.
FAU - Avila-Nava, Azalia
AU  - Avila-Nava A
AD  - Hospital Regional de Alta Especialidad de la Peninsula de Yucatan (HRAEPY), 
      Merida 97130, Yucatan, Mexico.
LA  - eng
GR  - E022/Universidad Modelo, Merida, Yucatan to A.A.-N.; Hospital Regional de Alta 
      Especialidad de la Peninsula de Yucatan, Merida, Yucatan/
PT  - Journal Article
DEP - 20231102
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC10669741
OTO - NOTNLM
OT  - Ramon flour
OT  - adipocytes
OT  - fatty liver
OT  - lipid metabolism
OT  - polyphenols
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:45
MHDA- 2023/11/25 12:46
PMCR- 2023/11/02
CRDT- 2023/11/25 01:06
PHST- 2023/09/29 00:00 [received]
PHST- 2023/10/21 00:00 [revised]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2023/11/25 12:46 [medline]
PHST- 2023/11/25 12:45 [pubmed]
PHST- 2023/11/25 01:06 [entrez]
PHST- 2023/11/02 00:00 [pmc-release]
AID - antiox12111957 [pii]
AID - antioxidants-12-01957 [pii]
AID - 10.3390/antiox12111957 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2023 Nov 2;12(11):1957. doi: 10.3390/antiox12111957.