PMID- 38001912
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231128
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 11
DP  - 2023 Oct 27
TI  - Intermediate Monocytes and Circulating Endothelial Cells: Interplay with Severity 
      of Atherosclerosis in Patients with Coronary Artery Disease and Type 2 Diabetes 
      Mellitus.
LID - 10.3390/biomedicines11112911 [doi]
LID - 2911
AB  - The aim was to investigate the association of monocyte heterogeneity and presence 
      of circulating endothelial cells with the severity of coronary atherosclerosis in 
      patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). 
      We recruited 62 patients with CAD, including 22 patients with DM2. The severity 
      of atherosclerosis was evaluated using Gensini Score. Numbers of classical 
      (CD14++CD16-), intermediate (CD14++CD16+), and non-classical (CD14+CD16++) 
      monocyte subsets; circulating endothelial progenitor cells; and the presence of 
      circulating endothelial cells were evaluated. Counts and frequencies of 
      intermediate monocytes, but not glycaemia parameters, were associated with the 
      severity of atherosclerosis in diabetic CAD patients (r(s) = 0.689; p = 0.001 and 
      r(s) = 0.632; p = 0.002, respectively). Frequency of Tie2+ cells was lower in 
      classical than in non-classical monocytes in CAD patients (p = 0.007), while in 
      patients with association of CAD and T2DM, differences between Tie2+ monocytes 
      subsets disappeared (p = 0.080). Circulating endothelial cells were determined in 
      100% of CAD+T2DM patients, and counts of CD14++CD16+ monocytes and concentration 
      of TGF-beta predicted the presence of circulating endothelial cells (sensitivity 
      92.3%; specificity 90.9%; AUC = 0.930). Thus, intermediate monocytes represent 
      one of the key determinants of the appearance of circulating endothelial cells in 
      all the patients with CAD, but are associated with the severity of 
      atherosclerosis only in patients with association of CAD and T2DM.
FAU - Kologrivova, Irina V
AU  - Kologrivova IV
AUID- ORCID: 0000-0003-4537-0008
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, 111A Kievskaya, Tomsk 634012, Russia.
FAU - Suslova, Tatiana E
AU  - Suslova TE
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, 111A Kievskaya, Tomsk 634012, Russia.
FAU - Koshelskaya, Olga A
AU  - Koshelskaya OA
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, 111A Kievskaya, Tomsk 634012, Russia.
FAU - Kravchenko, Elena S
AU  - Kravchenko ES
AUID- ORCID: 0000-0002-1235-9956
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, 111A Kievskaya, Tomsk 634012, Russia.
FAU - Kharitonova, Olga A
AU  - Kharitonova OA
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, 111A Kievskaya, Tomsk 634012, Russia.
FAU - Romanova, Ekaterina A
AU  - Romanova EA
AD  - Department of Biomedicine, Siberian State Medical University, 2 Moskovskii trakt, 
      Tomsk 634050, Russia.
FAU - Vyrostkova, Alexandra I
AU  - Vyrostkova AI
AD  - Department of Biomedicine, Siberian State Medical University, 2 Moskovskii trakt, 
      Tomsk 634050, Russia.
FAU - Boshchenko, Alla A
AU  - Boshchenko AA
AD  - Cardiology Research Institute, Tomsk National Research Medical Center, Russian 
      Academy of Sciences, 111A Kievskaya, Tomsk 634012, Russia.
LA  - eng
GR  - 122020300043-1/Ministry of Science and Higher Education (Russia)/
PT  - Journal Article
DEP - 20231027
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10669450
OTO - NOTNLM
OT  - TGF-beta
OT  - atherosclerosis
OT  - circulating endothelial cells
OT  - coronary artery disease
OT  - endothelial progenitor cells
OT  - monocytes
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:45
MHDA- 2023/11/25 12:46
PMCR- 2023/10/27
CRDT- 2023/11/25 01:07
PHST- 2023/09/21 00:00 [received]
PHST- 2023/10/23 00:00 [revised]
PHST- 2023/10/25 00:00 [accepted]
PHST- 2023/11/25 12:46 [medline]
PHST- 2023/11/25 12:45 [pubmed]
PHST- 2023/11/25 01:07 [entrez]
PHST- 2023/10/27 00:00 [pmc-release]
AID - biomedicines11112911 [pii]
AID - biomedicines-11-02911 [pii]
AID - 10.3390/biomedicines11112911 [doi]
PST - epublish
SO  - Biomedicines. 2023 Oct 27;11(11):2911. doi: 10.3390/biomedicines11112911.