PMID- 38002561
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231127
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 13
IP  - 11
DP  - 2023 Nov 17
TI  - Molecular Targeted Therapies in Glioblastoma Multiforme: A Systematic Overview of 
      Global Trends and Findings.
LID - 10.3390/brainsci13111602 [doi]
LID - 1602
AB  - This systematic review assesses current molecular targeted therapies for 
      glioblastoma multiforme (GBM), a challenging condition with limited treatment 
      options. Using PRISMA methodology, 166 eligible studies, involving 2526 patients 
      (61.49% male, 38.51% female, with a male-to-female ratio of 1.59/1), were 
      analyzed. In laboratory studies, 52.52% primarily used human glioblastoma cell 
      cultures (HCC), and 43.17% employed animal samples (mainly mice). Clinical 
      participants ranged from 18 to 100 years, with 60.2% using combined therapies and 
      39.8% monotherapies. Mechanistic categories included Protein Kinase 
      Phosphorylation (41.6%), Cell Cycle-Related Mechanisms (18.1%), 
      Microenvironmental Targets (19.9%), Immunological Targets (4.2%), and Other 
      Mechanisms (16.3%). Key molecular targets included Epidermal Growth Factor 
      Receptor (EGFR) (10.8%), Mammalian Target of Rapamycin (mTOR) (7.2%), Vascular 
      Endothelial Growth Factor (VEGF) (6.6%), and Mitogen-Activated Protein Kinase 
      (MEK) (5.4%). This review provides a comprehensive assessment of molecular 
      therapies for GBM, highlighting their varied efficacy in clinical and laboratory 
      settings, ultimately impacting overall and progression-free survival in GBM 
      management.
FAU - Begagic, Emir
AU  - Begagic E
AUID- ORCID: 0000-0002-3988-8911
AD  - Department of General Medicine, School of Medicine, Unversity of Zenica, 
      Travnicka 1, 72000 Zenica, Bosnia and Herzegovina.
FAU - Pugonja, Ragib
AU  - Pugonja R
AUID- ORCID: 0009-0004-3732-5260
AD  - Department of Anatomy, School of Medicine, University of Zenica, Travnicka 1, 
      72000 Zenica, Bosnia and Herzegovina.
AD  - Department of General Medicine, Primary Health Care Center, Nikole Subica 
      Zrinjskog bb., 72260 Busovaca, Bosnia and Herzegovina.
FAU - Beculic, Hakija
AU  - Beculic H
AD  - Department of General Medicine, Primary Health Care Center, Nikole Subica 
      Zrinjskog bb., 72260 Busovaca, Bosnia and Herzegovina.
AD  - Department of Neurosurgery, Cantonal Hospital Zenica, Crkvice 76, 72000 Zenica, 
      Bosnia and Herzegovina.
FAU - Celikovic, Amila
AU  - Celikovic A
AD  - Department of General Medicine, School of Medicine, Unversity of Zenica, 
      Travnicka 1, 72000 Zenica, Bosnia and Herzegovina.
FAU - Tandir Lihic, Lejla
AU  - Tandir Lihic L
AD  - Department of Neurology, Cantonal Hospital Zenica, Crkvice 76, 72000 Zenica, 
      Bosnia and Herzegovina.
FAU - Kadic Vukas, Samra
AU  - Kadic Vukas S
AD  - Department of Neurology, Cantonal Hospital Zenica, Crkvice 76, 72000 Zenica, 
      Bosnia and Herzegovina.
FAU - Cejvan, Lejla
AU  - Cejvan L
AD  - Department of General Medicine, School of Medicine, Unversity of Zenica, 
      Travnicka 1, 72000 Zenica, Bosnia and Herzegovina.
FAU - Skomorac, Rasim
AU  - Skomorac R
AD  - Department of Neurosurgery, Cantonal Hospital Zenica, Crkvice 76, 72000 Zenica, 
      Bosnia and Herzegovina.
AD  - Department of Surgery, School of Medicine, University of Zenica, Travnicka 1, 
      72000 Zenica, Bosnia and Herzegovina.
FAU - Selimovic, Edin
AU  - Selimovic E
AD  - Department of Surgery, School of Medicine, University of Zenica, Travnicka 1, 
      72000 Zenica, Bosnia and Herzegovina.
FAU - Jaganjac, Belma
AU  - Jaganjac B
AD  - Department of Histology, School of Medicine, University of Zenica, Travnicka 1, 
      72000 Zenica, Bosnia and Herzegovina.
FAU - Jukovic-Bihorac, Fatima
AU  - Jukovic-Bihorac F
AD  - Department of Histology, School of Medicine, University of Zenica, Travnicka 1, 
      72000 Zenica, Bosnia and Herzegovina.
AD  - Department of Pathology, School of Medicine, University of Zenica, Travnicka 1, 
      72000 Zenica, Bosnia and Herzegovina.
AD  - Department of Pathology, Cantonal Hospital Zenica, Crkvice 76, 72000 Zenica, 
      Bosnia and Herzegovina.
FAU - Jusic, Aldin
AU  - Jusic A
AD  - Department of Neurosurgery, Cantonal Hospital Zenica, Crkvice 76, 72000 Zenica, 
      Bosnia and Herzegovina.
FAU - Pojskic, Mirza
AU  - Pojskic M
AUID- ORCID: 0000-0002-6123-5589
AD  - Department of Neurosurgery, University Hospital Marburg, Baldingerstr., 35033 
      Marburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231117
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC10669565
OTO - NOTNLM
OT  - central nervous system
OT  - glioblastoma
OT  - molecular biology
OT  - target therapy
COIS- The authors declare no conflicts of interest.
EDAT- 2023/11/25 12:46
MHDA- 2023/11/25 12:47
PMCR- 2023/11/17
CRDT- 2023/11/25 01:10
PHST- 2023/09/23 00:00 [received]
PHST- 2023/11/10 00:00 [revised]
PHST- 2023/11/16 00:00 [accepted]
PHST- 2023/11/25 12:47 [medline]
PHST- 2023/11/25 12:46 [pubmed]
PHST- 2023/11/25 01:10 [entrez]
PHST- 2023/11/17 00:00 [pmc-release]
AID - brainsci13111602 [pii]
AID - brainsci-13-01602 [pii]
AID - 10.3390/brainsci13111602 [doi]
PST - epublish
SO  - Brain Sci. 2023 Nov 17;13(11):1602. doi: 10.3390/brainsci13111602.