PMID- 38002848
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231128
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 10
IP  - 11
DP  - 2023 Oct 30
TI  - An Integrated Approach Using HLAMatchmaker and Pirche II for Epitopic Matching in 
      Pediatric Kidney Transplant-A Romanian Single-Center Study.
LID - 10.3390/children10111756 [doi]
LID - 1756
AB  - (1) Background: Renal transplantation (KT) is the most efficient treatment for 
      chronic kidney disease among pediatric patients. Antigenic matching and epitopic 
      load should be the main criteria for choosing a renal graft in pediatric 
      transplantation. Our study aims to compare the integration of new 
      histocompatibility predictive algorithms with classical human leukocyte antigen 
      (HLA) matching regarding different types of pediatric renal transplants. (2) 
      Methods: We categorized our cohort of pediatric patients depending on their risk 
      level, type of donor and type of transplantation, delving into discussions 
      surrounding their mismatching values in relation to both the human leukocyte 
      antigen Matchmaker software (versions 4.0. and 3.1.) and the most recent version 
      of the predicted indirectly identifiable HLA epitopes (PIRCHE) II score. (3) 
      Results: We determined that the higher the antigen mismatch, the higher the 
      epitopic load for both algorithms. The HLAMatchmaker algorithm reveals a 
      noticeable difference in eplet load between living and deceased donors, whereas 
      PIRCHE II does not show the same distinction. Dialysis recipients have a higher 
      count of eplet mismatches, which demonstrates a significant difference according 
      to the transplantation type. Our results are similar to those of four similar 
      studies available in the current literature. (4) Conclusions: We suggest that an 
      integrated data approach employing PIRCHE II and HLAMatchmaker algorithms better 
      predicts histocompatibility in KT than classical HLA matching.
FAU - Aldea, Paul Luchian
AU  - Aldea PL
AD  - Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, 
      Romania.
FAU - Santionean, Maria Diana
AU  - Santionean MD
AD  - Department of Mother and Child, Iuliu Hatieganu University of Medicine and 
      Pharmacy, 400347 Cluj-Napoca, Romania.
FAU - Elec, Alina
AU  - Elec A
AUID- ORCID: 0000-0003-1691-6729
AD  - Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, 
      Romania.
FAU - Munteanu, Adriana
AU  - Munteanu A
AD  - Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, 
      Romania.
FAU - Antal, Oana
AU  - Antal O
AUID- ORCID: 0000-0002-0183-9815
AD  - Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, 
      Romania.
AD  - Department of Urology, Iuliu Hatieganu University of Medicine and Pharmacy, 
      400347 Cluj-Napoca, Romania.
FAU - Loga, Luminita
AU  - Loga L
AD  - Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, 
      Romania.
FAU - Moisoiu, Tudor
AU  - Moisoiu T
AD  - Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, 
      Romania.
AD  - Department of Urology, Iuliu Hatieganu University of Medicine and Pharmacy, 
      400347 Cluj-Napoca, Romania.
FAU - Elec, Florin Ioan
AU  - Elec FI
AD  - Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, 
      Romania.
AD  - Department of Urology, Iuliu Hatieganu University of Medicine and Pharmacy, 
      400347 Cluj-Napoca, Romania.
FAU - Delean, Dan
AU  - Delean D
AD  - Department of Mother and Child, Discipline of Pediatrics II, Iuliu Hatieganu 
      University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.
FAU - Bulata, Bogdan
AU  - Bulata B
AD  - Department of Mother and Child, Discipline of Pediatrics II, Iuliu Hatieganu 
      University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.
FAU - Rachisan Bot, Andreea Liana
AU  - Rachisan Bot AL
AD  - Department of Mother and Child, Discipline of Pediatrics II, Iuliu Hatieganu 
      University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
DEP - 20231030
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC10670802
OTO - NOTNLM
OT  - HLAMatchmaker
OT  - PIRCHE II
OT  - epitope
OT  - graft
OT  - kidney
OT  - mismatch
OT  - pediatric
OT  - renal
OT  - transplantation
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:47
MHDA- 2023/11/25 12:48
PMCR- 2023/10/30
CRDT- 2023/11/25 01:12
PHST- 2023/09/07 00:00 [received]
PHST- 2023/09/20 00:00 [revised]
PHST- 2023/10/25 00:00 [accepted]
PHST- 2023/11/25 12:48 [medline]
PHST- 2023/11/25 12:47 [pubmed]
PHST- 2023/11/25 01:12 [entrez]
PHST- 2023/10/30 00:00 [pmc-release]
AID - children10111756 [pii]
AID - children-10-01756 [pii]
AID - 10.3390/children10111756 [doi]
PST - epublish
SO  - Children (Basel). 2023 Oct 30;10(11):1756. doi: 10.3390/children10111756.