PMID- 38003237
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 22
DP  - 2023 Nov 7
TI  - Effect of Flavonoids on MCP-1 Expression in Human Coronary Artery Endothelial 
      Cells and Impact on MCP-1-Dependent Migration of Human Monocytes.
LID - 10.3390/ijms242216047 [doi]
LID - 16047
AB  - The monocyte chemoattractant protein-1 (MCP-1), also known as chemokine (CC 
      motif) ligand 2 (CCL2), is involved in the formation, progression, and 
      destabilization of atheromatous plaques. Flavonoids, found in fruits and 
      vegetables, have been associated with various health-promoting properties, 
      including antioxidant, anti-inflammatory, and cardioprotective effects. In the 
      present study, the flavonoids quercetin, kaempferol, and luteolin, but not 
      cannflavin A, were shown to substantially inhibit interleukin (IL)-1beta-induced 
      MCP-1 mRNA and protein expression in human coronary artery endothelial cells 
      (HCAEC). At the functional level, conditioned medium (CM) from IL-1beta-stimulated 
      HCAEC caused an increase in the migration of THP-1 monocytes compared with CM 
      from unstimulated HCAEC. However, this induction was suppressed when 
      IL-1beta-treated HCAEC were coincubated with quercetin, kaempferol, or luteolin. The 
      functional importance of MCP-1 in IL-1beta-induced monocyte migration was supported 
      by experiments showing that neutralization of MCP-1 in the CM of IL-1beta-treated 
      HCAEC led to a significant inhibition of migration. In addition, a 
      concentration-dependent induction of monocyte migration in the presence of 
      recombinant MCP-1 was demonstrated. Collectively, the flavonoids quercetin, 
      kaempferol, and luteolin were found to exert potential antiatherogenic effects in 
      HCAEC, challenging further studies with these compounds.
FAU - Bruser, Lea
AU  - Bruser L
AD  - Institute of Pharmacology and Toxicology, Rostock University Medical Center, 
      Schillingallee 70, 18057 Rostock, Germany.
FAU - Teichmann, Elisa
AU  - Teichmann E
AD  - Institute of Pharmacology and Toxicology, Rostock University Medical Center, 
      Schillingallee 70, 18057 Rostock, Germany.
FAU - Hinz, Burkhard
AU  - Hinz B
AUID- ORCID: 0000-0002-2529-0732
AD  - Institute of Pharmacology and Toxicology, Rostock University Medical Center, 
      Schillingallee 70, 18057 Rostock, Germany.
LA  - eng
PT  - Journal Article
DEP - 20231107
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Chemokine CCL2)
RN  - 0 (Kaempferols)
RN  - 0 (Flavonoids)
RN  - 9IKM0I5T1E (Quercetin)
RN  - KUX1ZNC9J2 (Luteolin)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Humans
MH  - *Chemokine CCL2/metabolism
MH  - *Monocytes/metabolism
MH  - Kaempferols/pharmacology/metabolism
MH  - Flavonoids/pharmacology/metabolism
MH  - Quercetin/pharmacology/metabolism
MH  - Endothelial Cells/metabolism
MH  - Coronary Vessels/metabolism
MH  - Luteolin/pharmacology
MH  - Cells, Cultured
MH  - Immunologic Factors/pharmacology
PMC - PMC10671372
OTO - NOTNLM
OT  - flavonoids
OT  - monocyte chemoattractant protein-1
OT  - monocyte migration
OT  - vascular endothelial cells
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:43
MHDA- 2023/11/27 12:42
PMCR- 2023/11/07
CRDT- 2023/11/25 01:14
PHST- 2023/09/19 00:00 [received]
PHST- 2023/10/26 00:00 [revised]
PHST- 2023/10/29 00:00 [accepted]
PHST- 2023/11/27 12:42 [medline]
PHST- 2023/11/25 12:43 [pubmed]
PHST- 2023/11/25 01:14 [entrez]
PHST- 2023/11/07 00:00 [pmc-release]
AID - ijms242216047 [pii]
AID - ijms-24-16047 [pii]
AID - 10.3390/ijms242216047 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Nov 7;24(22):16047. doi: 10.3390/ijms242216047.