PMID- 38003484
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 22
DP  - 2023 Nov 14
TI  - Sequence Variant Analysis of the APOCII Locus among an Arab Cohort.
LID - 10.3390/ijms242216293 [doi]
LID - 16293
AB  - Apolipoprotein CII (ApocII) plays a key role in regulating lipoprotein lipase 
      (LPL) in lipid metabolism and transport. Numerous polymorphisms within APOCII are 
      reportedly associated with type 2 diabetes mellitus (T2DM), dyslipidemia, and 
      aberrant plasma lipid levels. Few studies have investigated sequence variants at 
      APOCII loci and their association with metabolic disorders. This study aimed to 
      identify and characterize genetic variants by sequencing the full APOCII locus 
      and its flanking sequences in a sample of the Kuwaiti Arab population, including 
      patients with T2DM, hypertriglyceridemia, non-Arab patients with T2DM, and 
      healthy Arab controls. A total of 52 variants were identified in the noncoding 
      sequences: 45 single nucleotide polymorphisms, wherein five were novel, and seven 
      insertion deletions. The minor allele frequency (MAF) of the 47 previously 
      reported variants was similar to the global MAF and to that reported in major 
      populations. Sequence variant analysis predicted a conserved role for APOCII with 
      a potential role for rs5120 in T2DM and rs7133873 as an informative ethnicity 
      marker. This study adds to the ongoing research that attempts to identify 
      ethnicity-specific variants in the apolipoprotein gene loci and associated LPL 
      genes to elucidate the molecular mechanisms of metabolic disorders.
FAU - Al-Bustan, Suzanne A
AU  - Al-Bustan SA
AUID- ORCID: 0000-0002-1260-4632
AD  - Department of Biological Sciences, College of Science, Kuwait University, 
      Farwaniya 85700, Kuwait.
FAU - Alrashid, Maryam H
AU  - Alrashid MH
AD  - Department of Biological Sciences, College of Science, Kuwait University, 
      Farwaniya 85700, Kuwait.
FAU - Al-Serri, Ahmad E
AU  - Al-Serri AE
AD  - Unit of Human Genetics, Department of Pathology, Faculty of Medicine, Kuwait 
      University, Hawally 46300, Kuwait.
FAU - Annice, Babitha G
AU  - Annice BG
AD  - Department of Biological Sciences, College of Science, Kuwait University, 
      Farwaniya 85700, Kuwait.
FAU - Bahbahani, Hussain M
AU  - Bahbahani HM
AD  - Department of Biological Sciences, College of Science, Kuwait University, 
      Farwaniya 85700, Kuwait.
LA  - eng
GR  - RS 01/15/Kuwait University/
PT  - Journal Article
DEP - 20231114
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (apolipoprotein C-II (St Michael))
RN  - 0 (Apolipoprotein C-II)
RN  - 0 (Apolipoproteins)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Arabs/genetics
MH  - Apolipoprotein C-II
MH  - Apolipoproteins
PMC - PMC10671382
OTO - NOTNLM
OT  - APOCII
OT  - Arabs
OT  - Kuwait
OT  - T2DM
OT  - genetic variants
OT  - hypertriglyceridemia
OT  - sequencing
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:42
MHDA- 2023/11/27 16:18
PMCR- 2023/11/14
CRDT- 2023/11/25 01:16
PHST- 2023/10/23 00:00 [received]
PHST- 2023/11/09 00:00 [revised]
PHST- 2023/11/09 00:00 [accepted]
PHST- 2023/11/27 16:18 [medline]
PHST- 2023/11/25 12:42 [pubmed]
PHST- 2023/11/25 01:16 [entrez]
PHST- 2023/11/14 00:00 [pmc-release]
AID - ijms242216293 [pii]
AID - ijms-24-16293 [pii]
AID - 10.3390/ijms242216293 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Nov 14;24(22):16293. doi: 10.3390/ijms242216293.