PMID- 38003970
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 59
IP  - 11
DP  - 2023 Oct 30
TI  - Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and the Risk of 
      Developing Incidental Tuberculosis: A Population-Based Cohort Study.
LID - 10.3390/medicina59111920 [doi]
LID - 1920
AB  - Background and Objectives: Treatment for antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV) must deal with immunosuppression, as well as 
      infections associated with a compromised immune system, such as tuberculosis 
      (TB). Our aim was to examine the risk of incidental TB after diagnosis of AAV. 
      Materials and Methods: This retrospective population-based cohort study was based 
      on the data from the National Health Insurance Research Database in Taiwan. 
      Patients with newly diagnosed granulomatous polyangiitis or microscopic 
      polyangiitis were identified between 1 January 2000 and 31 December 2012. The 
      primary outcome was risk of incidental TB. Cox proportional hazard models were 
      used to evaluate the association between AAV and incidental TB. Results: A total 
      of 2257 patients with AAV and a propensity-score matched cohort of 9028 patients 
      were studied. Overall, patients with AAV were at a 1.48x higher risk of 
      contracting incidental TB than the patients in the matched cohort (adjusted HR 
      1.48; 95% confidence interval [CI], 1.02-2.15). Note that the highest risk of 
      contracting incidental TB was in the first two years following a diagnosis of 
      AAV, with a nearly 1-fold increase in risk (adjusted HR, 1.91; 95% CI, 
      1.01-3.60). Female AAV patients were 3.24x more likely than females without AAV 
      to develop TB (adjusted HR 3.24; 95% CI, 1.85-5.67). Conclusions: Patients with 
      AAV exhibit a 48% elevated TB risk, notably, a 91% increase within the first two 
      years postdiagnosis. Female AAV patients face a 3.24 times higher TB risk 
      compared to females without AAV. This study is limited by potential 
      misclassification and overestimation of AAV cases. Clinicians should closely 
      monitor TB risk in AAV patients, especially in females and the initial two years 
      following diagnosis.
FAU - Chan, Shan-Ho
AU  - Chan SH
AUID- ORCID: 0000-0002-8538-1046
AD  - Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine 
      and Management, Kaohsiung 82144, Taiwan.
FAU - Li, Ming-Feng
AU  - Li MF
AUID- ORCID: 0000-0003-3472-9070
AD  - Department of Medical Imaging and Radiology, Shu-Zen Junior College of Medicine 
      and Management, Kaohsiung 82144, Taiwan.
AD  - Department of Radiology, Kaohsiung Veteran General Hospital, Kaohsiung 813414, 
      Taiwan.
FAU - Ou, Shih-Hsiang
AU  - Ou SH
AD  - Division of Nephrology, Department of Internal Medicine, Kaohsiung Veterans 
      General Hospital, Kaohsiung 813414, Taiwan.
AD  - School of Nursing, Meiho University, Pingtung 91202, Taiwan.
FAU - Lin, Mei-Chen
AU  - Lin MC
AD  - Management Office for Health Data, China Medical University Hospital, Taichung 
      404327, Taiwan.
AD  - College of Medicine, China Medical University, Taichung 40402, Taiwan.
FAU - Wang, Jen-Hung
AU  - Wang JH
AUID- ORCID: 0000-0002-4946-8064
AD  - Department of Medical Research, Hualien Buddhist Tzu-Chi General Hospital, 
      Hualien 970473, Taiwan.
FAU - Lee, Po-Tsang
AU  - Lee PT
AD  - Division of Nephrology, Department of Internal Medicine, Kaohsiung Veterans 
      General Hospital, Kaohsiung 813414, Taiwan.
AD  - School of Nursing, Meiho University, Pingtung 91202, Taiwan.
FAU - Chen, Hsin-Yu
AU  - Chen HY
AUID- ORCID: 0000-0003-2093-0291
AD  - Division of Nephrology, Department of Internal Medicine, Kaohsiung Veterans 
      General Hospital, Kaohsiung 813414, Taiwan.
AD  - School of Nursing, Meiho University, Pingtung 91202, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20231030
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Granulomatosis with Polyangiitis/diagnosis
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Retrospective Studies
MH  - Cohort Studies
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/complications/epidemiology
MH  - *Tuberculosis/epidemiology
PMC - PMC10673265
OTO - NOTNLM
OT  - antineutrophil cytoplasmic antibody-associated vasculitis
OT  - population-based study
OT  - tuberculosis
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:45
MHDA- 2023/11/27 12:42
PMCR- 2023/10/30
CRDT- 2023/11/25 01:19
PHST- 2023/10/07 00:00 [received]
PHST- 2023/10/22 00:00 [revised]
PHST- 2023/10/26 00:00 [accepted]
PHST- 2023/11/27 12:42 [medline]
PHST- 2023/11/25 12:45 [pubmed]
PHST- 2023/11/25 01:19 [entrez]
PHST- 2023/10/30 00:00 [pmc-release]
AID - medicina59111920 [pii]
AID - medicina-59-01920 [pii]
AID - 10.3390/medicina59111920 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2023 Oct 30;59(11):1920. doi: 10.3390/medicina59111920.