PMID- 38005850
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 15
IP  - 11
DP  - 2023 Oct 29
TI  - Naringenin Improves Innate Immune Suppression after PRRSV Infection by 
      Reactivating the RIG-I-MAVS Signaling Pathway, Promoting the Production of IFN-I.
LID - 10.3390/v15112172 [doi]
LID - 2172
AB  - Porcine reproductive and respiratory syndrome (PRRS) has been prevalent for 
      nearly forty years since it was first reported. It has been one of the major 
      diseases jeopardizing the healthy development of the world swine industry, as 
      well as causing great economic losses to the industry's economic development. 
      Furthermore, no way has been found to combat the disease due to the 
      immunosuppressive properties of its pathogen porcine reproductive and respiratory 
      syndrome virus (PRRSV) infection. We previously examined the mRNA expression of 
      IFN-I in PRRSV-infected Marc-145 cells at different time periods using qRT-PCR, 
      and found that the mRNA expression of IFN-I in the late stage of PRRSV infection 
      showed suppression. Naringenin is a flavonoid found in citrus fruits and has a 
      very wide range of pharmacological activities. Therefore, the aim of the present 
      study was to investigate the modulatory effect of naringenin on the suppressed 
      innate immune response after PRRSV infection. The expression of IFN-I, IL-10, and 
      ISGs in the late stage of PRRSV infection was examined using qRT-PCR, and the 
      results showed that naringenin improved the expression of antiviral cytokines 
      suppressed by PRRSV infection. Further results showed that naringenin treatment 
      significantly up-regulated the expression of proteins related to the RIG-I-MAV 
      immune signaling pathway, and that naringenin could not significantly activate 
      the RIG-I-MAVS signaling pathway after the addition of the RIG-I inhibitor Cyclo. 
      Overall, these data demonstrated that naringenin could improve the innate immune 
      response suppressed by PRRSV infection by modulating the RIG-I-MAVS signaling 
      pathway. Therefore, our study will provide a theoretical basis for the 
      development of naringenin as a drug against immunosuppressive viral infectious 
      disease infections.
FAU - Yu, Jiaying
AU  - Yu J
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, China.
FAU - Shi, Haitao
AU  - Shi H
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, China.
FAU - Song, Ke
AU  - Song K
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, China.
FAU - Yang, Yuxin
AU  - Yang Y
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, China.
FAU - Li, Xinmiao
AU  - Li X
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, China.
FAU - Peng, Luyuan
AU  - Peng L
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, China.
FAU - Fu, Bendong
AU  - Fu B
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, China.
FAU - Yi, Pengfei
AU  - Yi P
AUID- ORCID: 0000-0002-6898-7388
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, China.
LA  - eng
PT  - Journal Article
DEP - 20231029
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - HN5425SBF2 (naringenin)
RN  - 0 (Interferon Type I)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Swine
MH  - Animals
MH  - *Porcine respiratory and reproductive syndrome virus/metabolism
MH  - Cell Line
MH  - *Interferon Type I/metabolism
MH  - Signal Transduction
MH  - *Porcine Reproductive and Respiratory Syndrome/drug therapy
MH  - Immunity, Innate
MH  - RNA, Messenger
PMC - PMC10674737
OTO - NOTNLM
OT  - PRRSV
OT  - RIG-I-MAVS
OT  - innate immune suppression
OT  - naringenin
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:42
MHDA- 2023/11/27 12:43
PMCR- 2023/10/29
CRDT- 2023/11/25 01:30
PHST- 2023/09/29 00:00 [received]
PHST- 2023/10/24 00:00 [revised]
PHST- 2023/10/25 00:00 [accepted]
PHST- 2023/11/27 12:43 [medline]
PHST- 2023/11/25 12:42 [pubmed]
PHST- 2023/11/25 01:30 [entrez]
PHST- 2023/10/29 00:00 [pmc-release]
AID - v15112172 [pii]
AID - viruses-15-02172 [pii]
AID - 10.3390/v15112172 [doi]
PST - epublish
SO  - Viruses. 2023 Oct 29;15(11):2172. doi: 10.3390/v15112172.