PMID- 38005873
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231129
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 15
IP  - 11
DP  - 2023 Oct 31
TI  - The Interplay of Genital Herpes with Cellular Processes: A Pathogenesis and 
      Therapeutic Perspective.
LID - 10.3390/v15112195 [doi]
LID - 2195
AB  - Genital herpes, primarily caused by herpes simplex virus-2 (HSV-2), remains a 
      pressing global health concern. Its remarkable ability to intertwine with 
      cellular processes, from harnessing host machinery for replication to subverting 
      antiviral defenses like autophagy and programmed cell death, exemplifies the 
      intricate interplay at the heart of its pathogenesis. While the biomedical 
      community has extensively researched antiviral interventions, the efficiency of 
      these strategies in managing HSV-2 remains suboptimal. Recognizing this, 
      attention has shifted toward leveraging host cellular components to regulate 
      HSV-2 replication and influence the cell cycle. Furthermore, innovative 
      interventional strategies-including drug repurposing, microbivacs, connecting the 
      host microbiome, and exploiting natural secondary metabolites-are emerging as 
      potential game changers. This review summarizes the key steps in HSV-2 
      pathogenesis and newly discovered cellular interactions, presenting the latest 
      developments in the field, highlighting existing challenges, and offering a fresh 
      perspective on HSV-2's pathogenesis and the potential avenues for its treatment 
      by targeting cellular proteins and pathways.
FAU - Borase, Hemant
AU  - Borase H
AUID- ORCID: 0000-0003-2097-1018
AD  - Department of Ophthalmology and Visual Sciences, University of Illinois at 
      Chicago, Chicago, IL 60612, USA.
FAU - Shukla, Deepak
AU  - Shukla D
AUID- ORCID: 0000-0002-3039-6953
AD  - Department of Ophthalmology and Visual Sciences, University of Illinois at 
      Chicago, Chicago, IL 60612, USA.
AD  - Department of Microbiology and Immunology, University of Illinois at Chicago, 
      Chicago, IL 60612, USA.
LA  - eng
GR  - R01 AI139768/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20231031
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Humans
MH  - *Herpes Genitalis/drug therapy/pathology
MH  - Herpesvirus 2, Human/physiology
MH  - Autophagy
MH  - Antiviral Agents/pharmacology/therapeutic use
MH  - *Herpes Simplex/drug therapy
PMC - PMC10675801
OTO - NOTNLM
OT  - antivirals
OT  - genital herpes
OT  - herpes simplex virus-2
OT  - immune response
OT  - microbiome
OT  - vaccines
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/25 12:47
MHDA- 2023/11/27 12:43
PMCR- 2023/10/31
CRDT- 2023/11/25 01:30
PHST- 2023/09/27 00:00 [received]
PHST- 2023/10/21 00:00 [revised]
PHST- 2023/10/25 00:00 [accepted]
PHST- 2023/11/27 12:43 [medline]
PHST- 2023/11/25 12:47 [pubmed]
PHST- 2023/11/25 01:30 [entrez]
PHST- 2023/10/31 00:00 [pmc-release]
AID - v15112195 [pii]
AID - viruses-15-02195 [pii]
AID - 10.3390/v15112195 [doi]
PST - epublish
SO  - Viruses. 2023 Oct 31;15(11):2195. doi: 10.3390/v15112195.