PMID- 38007590
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231129
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 14
IP  - 1
DP  - 2023 Nov 25
TI  - The rate of epigenetic drift scales with maximum lifespan across mammals.
PG  - 7731
LID - 10.1038/s41467-023-43417-6 [doi]
LID - 7731
AB  - Epigenetic drift or "disorder" increases across the mouse lifespan and is 
      suggested to underlie epigenetic clock signals. While the role of epigenetic 
      drift in determining maximum lifespan across species has been debated, robust 
      tests of this hypothesis are lacking. Here, we test if epigenetic disorder at 
      various levels of genomic resolution explains maximum lifespan across four mammal 
      species. We show that epigenetic disorder increases with age in all species and 
      at all levels of genomic resolution tested. The rate of disorder accumulation 
      occurs faster in shorter lived species and corresponds to species adjusted 
      maximum lifespan. While the density of cytosine-phosphate-guanine dinucleotides 
      ("CpGs") is negatively associated with the rate of age-associated disorder 
      accumulation, it does not fully explain differences across species. Our findings 
      support the hypothesis that the rate of epigenetic drift explains maximum 
      lifespan and provide partial support for the hypothesis that CpG density buffers 
      against epigenetic drift.
CI  - (c) 2023. The Author(s).
FAU - Bertucci-Richter, Emily M
AU  - Bertucci-Richter EM
AUID- ORCID: 0000-0002-8348-0024
AD  - Savannah River Ecology Laboratory, University of Georgia, Aiken, SC, 29802, USA.
AD  - Eugene P. Odum School of Ecology, University of Georgia, Athens, GA, 30602, USA.
FAU - Parrott, Benjamin B
AU  - Parrott BB
AUID- ORCID: 0000-0002-2391-2470
AD  - Savannah River Ecology Laboratory, University of Georgia, Aiken, SC, 29802, USA. 
      benparrott@srel.uga.edu.
AD  - Eugene P. Odum School of Ecology, University of Georgia, Athens, GA, 30602, USA. 
      benparrott@srel.uga.edu.
LA  - eng
GR  - R56 AG078336/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20231125
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Longevity/genetics
MH  - *Epigenesis, Genetic
MH  - DNA Methylation/genetics
MH  - CpG Islands/genetics
MH  - Mammals/genetics
MH  - Aging/genetics
PMC - PMC10676422
COIS- The authors declare no competing interests.
EDAT- 2023/11/26 07:44
MHDA- 2023/11/27 18:42
PMCR- 2023/11/25
CRDT- 2023/11/25 23:38
PHST- 2023/09/15 00:00 [received]
PHST- 2023/11/09 00:00 [accepted]
PHST- 2023/11/27 18:42 [medline]
PHST- 2023/11/26 07:44 [pubmed]
PHST- 2023/11/25 23:38 [entrez]
PHST- 2023/11/25 00:00 [pmc-release]
AID - 10.1038/s41467-023-43417-6 [pii]
AID - 43417 [pii]
AID - 10.1038/s41467-023-43417-6 [doi]
PST - epublish
SO  - Nat Commun. 2023 Nov 25;14(1):7731. doi: 10.1038/s41467-023-43417-6.