PMID- 38007756
OWN - NLM
STAT- MEDLINE
DCOM- 20240130
LR  - 20240130
IS  - 1879-8365 (Electronic)
IS  - 0926-9630 (Linking)
VI  - 308
DP  - 2023 Nov 23
TI  - Bio Informatics Analysis of the Relationship Between Mammalian Target of 
      Rapamycin and Colorectal Cancer.
PG  - 322-328
LID - 10.3233/SHTI230856 [doi]
AB  - OBJECTIVE: The purpose of this paper is to promote the medical treatment of 
      colorectal cancer in our country and to save the lives of patients with 
      colorectal cancer by studying mammalian target of rapamycin (mTOR) and the 
      biologic information analysis of colorectal cancer. METHODS: We analyzed mTOR 
      expression and survival differences using data from Coad & read from the TCGA 
      public database and explored the coexpression regulatory network of mTOR. 
      mTOR-regulated mirnas were screened using the Linked Omics database. In addition, 
      we explored the association of mTOR with drug sensitivity, immune cell 
      correlations, microsatellite deletions, tumor mutational burden, and mutational 
      analysis. RESULTS: The expression and survival of mTOR were significant different 
      in colorectal cancer, and were related to the sensitivity of Bleomycin, Cisplatin 
      and Gemcitabine. mTOR is associated with dendritic cell activation, NK cell 
      dormancy, dendritic cell dormancy, and eosinophil granulocyte. mTOR is associated 
      with microsatellite deletions, and tumor mutational load. CONCLUSIONS: Based on 
      these findings, we consumer mTOR as a biomarker for the diagnosis and prognosis 
      of colorectal cancer.
FAU - Han, Lihong
AU  - Han L
AD  - Key Laboratory of Translational Oncology, Putian University, Putian, CN.
FAU - Lin, Lirong
AU  - Lin L
AD  - Key Laboratory of Translational Oncology, Putian University, Putian, CN.
FAU - Chen, Jingru
AU  - Chen J
AD  - Key Laboratory of Translational Oncology, Putian University, Putian, CN.
FAU - Yan, Bin
AU  - Yan B
AD  - Key Laboratory of Translational Oncology, Putian University, Putian, CN.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
RN  - 0 (MicroRNAs)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
MH  - Humans
MH  - Cell Line, Tumor
MH  - *Colorectal Neoplasms/diagnosis/genetics
MH  - *MicroRNAs/genetics
MH  - Prognosis
MH  - *TOR Serine-Threonine Kinases/metabolism
OTO - NOTNLM
OT  - bioinformatics
OT  - colorectal cancer
OT  - mammalian target of rapamycin
OT  - signaling pathways
EDAT- 2023/11/26 18:41
MHDA- 2023/11/28 06:42
CRDT- 2023/11/26 15:21
PHST- 2023/11/28 06:42 [medline]
PHST- 2023/11/26 18:41 [pubmed]
PHST- 2023/11/26 15:21 [entrez]
AID - SHTI230856 [pii]
AID - 10.3233/SHTI230856 [doi]
PST - ppublish
SO  - Stud Health Technol Inform. 2023 Nov 23;308:322-328. doi: 10.3233/SHTI230856.