PMID- 38009058
OWN - NLM
STAT- MEDLINE
DCOM- 20231128
LR  - 20231214
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Linking)
VI  - 90
IP  - 6
DP  - 2023 Dec
TI  - Association of human leukocyte antigen-G and -F with recurrent miscarriage and 
      implantation failure: A systematic review and meta-analysis.
PG  - e13792
LID - 10.1111/aji.13792 [doi]
AB  - PROBLEM: The immune system plays an essential role in embryonic implantation and 
      pregnancy, but the molecular details remain controversial. In the past four 
      decades, human leukocyte antigen (HLA)-G and -F have garnered significant 
      attention. METHOD OF STUDY: MEDLINE, EMBASE, Web of Science, and the Cochrane 
      Trials Registry were searched from their inception dates until December 2022. 
      Studies were selected following PRISMA guidelines. Meta-analyses were used to 
      assess the relationship of soluble HLA-G (sHLA-G) and HLA-G 3'-untranslated 
      region polymorphisms with recurrent miscarriage (RM) and recurrent implantation 
      failure (RIF). Narrative synthesis was conducted to determine the association of 
      RM with other single nucleotide polymorphisms (SNPs) and HLA-G protein in tissues 
      and of RIF with HLA-F. Risk-of-bias was assessed using ROBINS-I. Publication bias 
      was assessed using Egger's and Begg's tests. RESULTS: Finally, 42 articles were 
      eligible for inclusion in the systematic review (32 in the meta-analysis; 13 in 
      narrative synthesis). We found a significant association between the 14-bp 
      ins/del HLA-G polymorphism and RM risk, but no definitive association with RIF 
      risk. Women with RM had lower blood concentrations of sHLA-G during pregnancy and 
      non-pregnancy than did controls. For women in the RIF group, no significant 
      difference was found. CONCLUSION: HLA-G protein and gene expression levels may be 
      closely related to RM. The relevance of HLA-G to RIF is still being determined. A 
      narrative synthesis of current studies has shown that HLA-F is likely associated 
      with RIF.
CI  - (c) 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Han, Nana
AU  - Han N
AUID- ORCID: 0009-0003-2027-0120
AD  - Clinical medical school, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
FAU - Xia, Wanting
AU  - Xia W
AD  - Gynecology Department, Hospital of Chengdu University of TCM, Chengdu, China.
FAU - Zhu, Can
AU  - Zhu C
AD  - Clinical medical school, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
FAU - Zhang, Xuan
AU  - Zhang X
AD  - Clinical medical school, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
FAU - Wang, Fan
AU  - Wang F
AD  - Clinical medical school, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
FAU - Yin, Zhixing
AU  - Yin Z
AD  - Clinical medical school, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
FAU - Zeng, Qian
AU  - Zeng Q
AD  - Gynecology Department, Hospital of Chengdu University of TCM, Chengdu, China.
LA  - eng
GR  - 82174430/National Natural Science Foundation of China/
GR  - 81973901/National Natural Science Foundation of China/
GR  - 2020YFSY0043/Sichuan Province's Science and Technology Project Fund of China/
GR  - 030054275/School level fund of Chengdu University of Traditional Chinese 
      Medicine/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA-G Antigens)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - *HLA-G Antigens
MH  - Embryo Implantation/genetics
MH  - Polymorphism, Single Nucleotide
MH  - *Abortion, Habitual/genetics
MH  - GTP-Binding Proteins
OTO - NOTNLM
OT  - HLA-F antigens
OT  - HLA-G antigens
OT  - embryo implantation
OT  - habitual abortion
OT  - immunology
EDAT- 2023/11/27 06:47
MHDA- 2023/11/28 06:42
CRDT- 2023/11/27 03:41
PHST- 2023/09/21 00:00 [revised]
PHST- 2023/07/16 00:00 [received]
PHST- 2023/10/14 00:00 [accepted]
PHST- 2023/11/28 06:42 [medline]
PHST- 2023/11/27 06:47 [pubmed]
PHST- 2023/11/27 03:41 [entrez]
AID - 10.1111/aji.13792 [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2023 Dec;90(6):e13792. doi: 10.1111/aji.13792.