PMID- 38009477
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240430
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 37
IP  - 12
DP  - 2023 Dec
TI  - Treating posttraumatic stress disorder and alcohol use disorder comorbidity: 
      Current pharmacological therapies and the future of MDMA-integrated 
      psychotherapy.
PG  - 1182-1189
LID - 10.1177/02698811231200880 [doi]
AB  - Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) frequently 
      co-occur in patients who have experienced trauma. This comorbidity leads to a 
      vicious cycle where PTSD symptoms beget heavy drinking and vice versa. There are 
      no FDA-approved medications to treat PTSD-AUD; therefore, individuals suffering 
      from this comorbidity are treated with medication approved to treat the disorders 
      separately or with off-label pharmacological interventions. However, these 
      medications are limited in their efficacy for treating PTSD-AUD comorbidity. 
      Emerging research on the nonclassical psychedelic drug 
      3,4-methylenedioxymethamphetamine (MDMA) suggests that it may be an effective 
      drug used in conjunction with psychotherapy. The following reviews the current 
      research for clinical pharmacotherapies, as well as MDMA-integrative 
      psychotherapy as they pertain to PTSD and AUD in isolation and co-occurrence. 
      Future directions for the role of psychedelic-integrative therapy for the 
      treatment of this comorbidity are discussed.
FAU - Gully, Brian J
AU  - Gully BJ
AD  - Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA.
AD  - Department of Behavioral and Social Sciences, School of Public Health, Brown 
      University, Providence, RI, USA.
FAU - Eaton, Erica
AU  - Eaton E
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Providence, RI, USA.
AD  - Providence Veterans Affairs Medical Center, Providence, RI, USA.
FAU - Capone, Christy
AU  - Capone C
AUID- ORCID: 0000-0002-1720-171X
AD  - Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA.
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Providence, RI, USA.
AD  - Providence Veterans Affairs Medical Center, Providence, RI, USA.
FAU - Haass-Koffler, Carolina L
AU  - Haass-Koffler CL
AUID- ORCID: 0000-0002-5634-5679
AD  - Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA.
AD  - Department of Behavioral and Social Sciences, School of Public Health, Brown 
      University, Providence, RI, USA.
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown 
      University, Providence, RI, USA.
AD  - Carney Institute for Brain Science, Brown University, Providence, RI, USA.
LA  - eng
GR  - P20 GM130414/GM/NIGMS NIH HHS/United States
GR  - R01 AA027760/AA/NIAAA NIH HHS/United States
GR  - R21 AA027614/AA/NIAAA NIH HHS/United States
GR  - R01 AA026589/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20231127
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - 0 (Hallucinogens)
SB  - IM
MH  - Humans
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/therapeutic use
MH  - *Alcoholism/drug therapy/epidemiology
MH  - *Stress Disorders, Post-Traumatic/drug therapy/diagnosis
MH  - *Hallucinogens/therapeutic use
MH  - Psychotherapy
MH  - Comorbidity
OTO - NOTNLM
OT  - Alcohol use disorder
OT  - comorbidity
OT  - posttraumatic stress disorder
OT  - psychedelics
COIS- Declaration of conflicting interestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/11/27 12:42
MHDA- 2023/12/17 13:19
CRDT- 2023/11/27 06:27
PHST- 2023/12/17 13:19 [medline]
PHST- 2023/11/27 12:42 [pubmed]
PHST- 2023/11/27 06:27 [entrez]
AID - 10.1177/02698811231200880 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2023 Dec;37(12):1182-1189. doi: 10.1177/02698811231200880. 
      Epub 2023 Nov 27.