PMID- 38010852
OWN - NLM
STAT- MEDLINE
DCOM- 20240130
LR  - 20240131
IS  - 1099-1654 (Electronic)
IS  - 1052-9276 (Linking)
VI  - 34
IP  - 1
DP  - 2024 Jan
TI  - The association between various viral infections and multiple sclerosis: An 
      umbrella review on systematic review and meta-analysis.
PG  - e2494
LID - 10.1002/rmv.2494 [doi]
AB  - Multiple Sclerosis (MS) is one of the immune-mediated demyelinating disorders. 
      Multiple components, including the environment and genetics, are possible factors 
      in the pathogenesis of MS. Also, it can be said that infections are a key 
      component of the host's response to MS development. Finally, we evaluated the 
      relationship between different pathogens and MS disease in this umbrella 
      research. We systematically collected and analysed multiple meta-analyses focused 
      on one particular topic. We utilised the Scopus, PubMed, and Web of Science 
      databases starting with inception until 30 May 2023. The methodological quality 
      of the analysed meta-analysis has been determined based on Assessing the 
      Methodological Quality of Systematic Reviews 2 and Grade, and graph construction 
      and statistical analysis were conducted using Comprehensive Meta-Analysis. The 
      Confidence Interval of effect size was 95% in meta-analyses, and p < 0.05 
      indicated a statistically meaningful relationship. The included studies evaluated 
      the association between MS and 12 viruses containing SARS-CoV-2, Epstein-Barr 
      virus (EBV), Hepatitis B virus, varicella-zoster virus (VZV), human herpesvirus 6 
      (HHV-6), HHV-7, HHV-8, HSV-1, HSV-2, Cytomegalovirus, Human Papillomavirus, and 
      influenza. SARS-CoV-2, with a 3.74 odds ratio, has a significantly more potent 
      negative effect on MS among viral infections. After that, EBV, HHV-6, HSV-2, and 
      VZV, respectively, with 3.33, 2.81, 1.76, and 1.72 odds ratios, had a 
      significantly negative relationship with MS (p < 0.05). Although the theoretical 
      evidence mostly indicates that EBV has the greatest effect on MS, recent 
      epidemiological studies have challenged this conclusion and put forward 
      possibilities that SARS-CoV-2 is the culprit. Hence, it was necessary to 
      investigate the effects of SARS-CoV-2 and EBV on MS.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Bakhshi, Arash
AU  - Bakhshi A
AD  - Student Research Committee, School of Medicine, Guilan University of Medical 
      Sciences, Rasht, Iran.
FAU - Eslami, Narges
AU  - Eslami N
AD  - Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical 
      Sciences, Rasht, Iran.
FAU - Norouzi, Naeim
AU  - Norouzi N
AD  - Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical 
      Sciences, Rasht, Iran.
FAU - Letafatkar, Negin
AU  - Letafatkar N
AD  - Student Research Committee, School of Medicine, Guilan University of Medical 
      Sciences, Rasht, Iran.
AD  - Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical 
      Sciences, Rasht, Iran.
FAU - Amini-Salehi, Ehsan
AU  - Amini-Salehi E
AD  - Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical 
      Sciences, Rasht, Iran.
FAU - Hassanipour, Soheil
AU  - Hassanipour S
AUID- ORCID: 0000-0002-6661-4908
AD  - Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical 
      Sciences, Rasht, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20231127
PL  - England
TA  - Rev Med Virol
JT  - Reviews in medical virology
JID - 9112448
SB  - IM
MH  - Humans
MH  - *Multiple Sclerosis/epidemiology
MH  - Herpesvirus 4, Human
MH  - *Epstein-Barr Virus Infections/complications/epidemiology
MH  - *Virus Diseases/complications/epidemiology
MH  - *Viruses
MH  - Herpesvirus 3, Human
OTO - NOTNLM
OT  - multiple sclerosis
OT  - umbrella review
OT  - viral infection
EDAT- 2023/11/27 18:43
MHDA- 2024/01/30 12:43
CRDT- 2023/11/27 12:13
PHST- 2023/11/05 00:00 [revised]
PHST- 2023/08/09 00:00 [received]
PHST- 2023/11/14 00:00 [accepted]
PHST- 2024/01/30 12:43 [medline]
PHST- 2023/11/27 18:43 [pubmed]
PHST- 2023/11/27 12:13 [entrez]
AID - 10.1002/rmv.2494 [doi]
PST - ppublish
SO  - Rev Med Virol. 2024 Jan;34(1):e2494. doi: 10.1002/rmv.2494. Epub 2023 Nov 27.