PMID- 38010903
OWN - NLM
STAT- MEDLINE
DCOM- 20231129
LR  - 20231129
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 43
IP  - 2
DP  - 2023 Dec
TI  - Diminished ovarian reserve is associated with metabolic disturbances and 
      hyperhomocysteinemia in women with infertility.
PG  - 2282722
LID - 10.1080/01443615.2023.2282722 [doi]
AB  - BACKGROUND: To distinguish the metabolic profile between women with diminished 
      ovarian reserve (DOR) and those with normal ovarian reserve (NOR). METHODS: In 
      this retrospective study, we enrolled 524 women under the age of 40 who were 
      experiencing infertility: 261 in the DOR group and 263 in the NOR group. Physical 
      characteristics and metabolic parameters were compared between these two groups. 
      RESULTS: Women with DOR exhibited a higher propensity for elevated parameters 
      including body mass index (BMI), systolic blood pressure (SBP), diastolic blood 
      pressure (DBP), as well as heightened serum levels of homocysteine (Hcy), 
      triglycerides (TG), low-density lipoprotein (LDL), and triglyceride-glucose (TyG) 
      index, while concurrently experiencing reduced serum levels of high-density 
      lipoprotein (HDL) (P < 0.05). Furthermore, the incidence rates of TG >/= 
      1.7 mmol/L, hyperhomocysteinemia (HHcy), BMI >/= 25 kg/m(2), SBP/DBP >/= 130/85 mmHg, 
      and metabolic syndrome (MS) were significantly elevated within the DOR group as 
      compared to the NOR group (P < 0.05). CONCLUSION: The prevalence of metabolic 
      disturbances and HHcy were notably elevated in women with infertility and DOR 
      compared to those with NOR.
FAU - Lu, Yuehong
AU  - Lu Y
AD  - Center for Reproductive Medicine of Shaoxing Women and Children's Hospital, 
      Shaoxing, China.
FAU - Xia, Zhoulan
AU  - Xia Z
AUID- ORCID: 0000-0002-0571-9765
AD  - Center for Reproductive Medicine of Shaoxing Women and Children's Hospital, 
      Shaoxing, China.
LA  - eng
PT  - Journal Article
DEP - 20231127
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of 
      Obstetrics and Gynaecology
JID - 8309140
RN  - 0 (Triglycerides)
SB  - IM
MH  - Humans
MH  - Female
MH  - Retrospective Studies
MH  - *Hyperhomocysteinemia/complications/epidemiology
MH  - *Ovarian Reserve
MH  - *Infertility
MH  - *Metabolic Syndrome/complications/epidemiology
MH  - Triglycerides
MH  - *Ovarian Diseases
OAB - This study focused on the metabolic condition of women who had difficulty getting 
      pregnant and had a decreased ovarian reserve. The findings indicated that these 
      women had a higher likelihood of glucose and lipid metabolic disorders and 
      elevated serum homocysteine levels compared to those with a normal ovarian 
      reserve. These metabolic issues and elevated serum homocysteine levels were 
      associated with an increased risk of cardiovascular disease.
OABL- eng
OTO - NOTNLM
OT  - Cardiovascular risk
OT  - dyslipidemia
OT  - hyperhomocysteinemia
OT  - metabolic disturbances
OT  - ovarian reserve
EDAT- 2023/11/27 18:44
MHDA- 2023/11/29 06:42
CRDT- 2023/11/27 12:24
PHST- 2023/11/29 06:42 [medline]
PHST- 2023/11/27 18:44 [pubmed]
PHST- 2023/11/27 12:24 [entrez]
AID - 10.1080/01443615.2023.2282722 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2023 Dec;43(2):2282722. doi: 10.1080/01443615.2023.2282722. 
      Epub 2023 Nov 27.