PMID- 38011318
OWN - NLM
STAT- MEDLINE
DCOM- 20231219
LR  - 20231219
IS  - 2576-6422 (Electronic)
IS  - 2576-6422 (Linking)
VI  - 6
IP  - 12
DP  - 2023 Dec 18
TI  - Progress in Programmable DNA-Aided Self-Assembly of the Master Frame of a Drug 
      Delivery System.
PG  - 5125-5144
LID - 10.1021/acsabm.3c00636 [doi]
AB  - Every year cancer causes approximately 10 million deaths globally. Researchers 
      have developed numerous targeted drug delivery systems (DDSs) with nanoparticles, 
      polymers, and liposomes, but these synthetic materials have poor degradability 
      and low biocompatibility. Because DNA nanostructures have good degradability and 
      high biocompatibility, extensive studies have been performed to construct DDSs 
      with DNA nanostructures as the molecular-layer master frame (MF) assembled via 
      programmable DNA-aided self-assembly for targeted drug release. To learn the 
      progressing trend of self-assembly techniques and keep pace with their recent 
      rapid advancements, it is crucial to provide an overview of their past and recent 
      progress. In this review article, we first present the techniques to assemble the 
      MF of a DDS with solely DNA strands; to assemble MFs with one or more additional 
      type of construction materials, e.g., polymers (including RNA and protein), 
      inorganic nanoparticle, or metal ions, in addition to DNA strands; and to 
      assemble the more complex DNA nanocomplexes. It is observed that both the 
      techniques used and the MFs constructed have become increasingly complex and that 
      the DDS constructed has an increasing number of advanced functions. From our 
      focused review, we anticipate that DDSs with the MF of multiple building 
      materials and DNA nanocomplexes will attract an increasing number of researchers' 
      interests. On the basis of knowledge about materials and functional components 
      (e.g., targeting aptamers/peptides/antibodies and stimuli for drug release) 
      obtained from previously performed studies, researchers can combine more 
      materials with DNA strands to assemble more powerful MFs and incorporate more 
      components to endow DDSs with improved or additional properties/functions, 
      thereby subsequently contributing to cancer prevention.
FAU - Yang, Gary Q
AU  - Yang GQ
AUID- ORCID: 0000-0001-9630-9704
AD  - College of Bioscience and Bioengineering, Jiangxi Agricultural University, 
      Nanchang, Jiangxi 330045, P. R. China.
FAU - Cai, Weibin
AU  - Cai W
AUID- ORCID: 0000-0002-7967-2699
AD  - School of Chemical and Environmental Engineering, China University of Mining and 
      Technology, Beijing 100083, P. R. China.
FAU - Zhang, Zhiwen
AU  - Zhang Z
AD  - College of Bioscience and Bioengineering, Jiangxi Agricultural University, 
      Nanchang, Jiangxi 330045, P. R. China.
FAU - Wang, Yujun
AU  - Wang Y
AD  - Department of Chemical Engineering, Tsinghua University, Beijing 100084, P. R. 
      China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231127
PL  - United States
TA  - ACS Appl Bio Mater
JT  - ACS applied bio materials
JID - 101729147
RN  - 9007-49-2 (DNA)
RN  - 0 (Polymers)
SB  - IM
MH  - Humans
MH  - *Nanostructures/chemistry
MH  - Drug Delivery Systems
MH  - DNA/chemistry
MH  - Polymers
MH  - *Neoplasms/drug therapy
OTO - NOTNLM
OT  - DNA-aided
OT  - drug delivery systems
OT  - master frame
OT  - nanostructures
OT  - programmable
OT  - self-assemble
EDAT- 2023/11/27 18:44
MHDA- 2023/12/19 06:42
CRDT- 2023/11/27 14:33
PHST- 2023/12/19 06:42 [medline]
PHST- 2023/11/27 18:44 [pubmed]
PHST- 2023/11/27 14:33 [entrez]
AID - 10.1021/acsabm.3c00636 [doi]
PST - ppublish
SO  - ACS Appl Bio Mater. 2023 Dec 18;6(12):5125-5144. doi: 10.1021/acsabm.3c00636. 
      Epub 2023 Nov 27.