PMID- 38011675
OWN - NLM
STAT- MEDLINE
DCOM- 20240229
LR  - 20240229
IS  - 1096-0929 (Electronic)
IS  - 1096-0929 (Linking)
VI  - 198
IP  - 1
DP  - 2024 Feb 28
TI  - Long-lasting developmental effects in rat offspring after maternal exposure to 
      acetamiprid in the drinking water during gestation.
PG  - 61-75
LID - 10.1093/toxsci/kfad122 [doi]
AB  - Neonicotinoids (NNTs) are a class of insecticides proposed to be safe for pest 
      control in urban, suburban, and agricultural applications. However, little is 
      known about their developmental effects after repeated low-dose exposures during 
      gestation. Here, we tested a dose considered subthreshold for maternal toxicity 
      in rats (6 mg/kg/day) by assessing several morphological, biochemical, and 
      neurobehavioral features in preterm fetuses and developing pups after maternal 
      administration of the NTT acetamiprid (ACP) dissolved in the drinking water 
      during gestational days (GD) 2-19. The exploratory evaluation included monitoring 
      maternal body weight gain, fetal viability, body weight and sex ratio, cephalic 
      length, neonatal body weight and sex ratio, metabolic enzymes in the placenta, 
      maternal blood and fetal liver, and anogenital distance and surface righting 
      response during infancy. We also used the circling training test to study the 
      integrity of the associative-spatial-motor response in adolescence. Results 
      showed no consistent findings indicating maternal, reproductive or developmental 
      toxicity. However, we found ACP effects on maternal body weight gain, placental 
      butyrylcholinesterase activity, and neurobehavioral responses, suggestive of a 
      mild toxic action. Thus, our study showed a trend for developmental 
      susceptibility at a dose so far considered subtoxic. Although the ACP 
      concentration in environmental samples of surface water and groundwater has been 
      mostly reported to be much lower than that used in our study, our results suggest 
      that the ACP point of departure used in current guidelines aimed to prevent 
      developmental effects may need to be verified by complementary sensitive 
      multiple-endpoint testing in the offspring.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Society of Toxicology. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Longoni, Victoria
AU  - Longoni V
AD  - Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires 
      (UBA), Buenos Aires C1428EGA, Argentina.
FAU - Kandel Gambarte, Paula Cristina
AU  - Kandel Gambarte PC
AD  - Instituto de Quimica Biologica de la Facultad de Ciencias Exactas y Naturales 
      (IQUIBICEN-CONICET) and FCEyN, UBA, Buenos Aires C1428EGA, Argentina.
FAU - Rueda, Lis
AU  - Rueda L
AD  - FCEyN, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina.
FAU - Fuchs, Julio Silvio
AU  - Fuchs JS
AD  - Instituto IQUIBICEN-CONICET and Departamento Quimica Biologica, FCEyN, UBA, 
      Buenos Aires C1428EGA, Argentina.
FAU - Rovedatti, Maria Gabriela
AU  - Rovedatti MG
AD  - Departamentos Quimica Biologica and Biodiversidad y Biologia Experimental, 
      IQUIBICEN-CONICET, FCEyN, UBA, Buenos Aires C1428EGA, Argentina.
FAU - Wolansky, Marcelo Javier
AU  - Wolansky MJ
AD  - Departamento Quimica Biologica, IQUIBICEN-CONICET, FCEyN, UBA, Buenos Aires 
      C1428EGA, Argentina.
LA  - eng
GR  - PIP 11220120100680CO/Argentina National Research Council/
GR  - University of Buenos Aires/
GR  - 20020130100862BA/UBACYT research/
GR  - UBA Secretary of Science and Investigation/
GR  - Biological Sciences students/
PT  - Journal Article
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Drinking Water)
RN  - 5HL5N372P0 (acetamiprid)
RN  - EC 3.1.1.8 (Butyrylcholinesterase)
RN  - 0 (Neonicotinoids)
SB  - IM
MH  - Rats
MH  - Pregnancy
MH  - Animals
MH  - Female
MH  - Humans
MH  - *Maternal Exposure/adverse effects
MH  - *Drinking Water
MH  - Rats, Sprague-Dawley
MH  - Butyrylcholinesterase
MH  - Placenta
MH  - Body Weight
MH  - Neonicotinoids/toxicity
OTO - NOTNLM
OT  - developmental toxicity
OT  - maternal exposure
OT  - neonicotinoids
OT  - rats
EDAT- 2023/11/27 18:42
MHDA- 2024/02/29 06:43
CRDT- 2023/11/27 16:34
PHST- 2024/02/29 06:43 [medline]
PHST- 2023/11/27 18:42 [pubmed]
PHST- 2023/11/27 16:34 [entrez]
AID - 7451857 [pii]
AID - 10.1093/toxsci/kfad122 [doi]
PST - ppublish
SO  - Toxicol Sci. 2024 Feb 28;198(1):61-75. doi: 10.1093/toxsci/kfad122.