PMID- 38012083
OWN - NLM
STAT- MEDLINE
DCOM- 20240320
LR  - 20240320
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 94
IP  - 3
DP  - 2024 Mar
TI  - Patient perspectives of quality of life in chronic limb-threatening ischemia: a 
      qualitative study.
PG  - 429-437
LID - 10.1111/ans.18791 [doi]
AB  - BACKGROUND: Quality of life (QOL) is an outcome that matters to patients with 
      chronic limb-threatening ischemia (CLTI). However, we identified the lack of and 
      need for a CLTI-specific QOL instrument. Our group is developing this instrument 
      which requires a deep understanding of patient perspectives of QOL in CLTI. 
      METHODS: Qualitative inquiry with patient and public involvement was performed in 
      accordance with the Standards for Reporting Qualitative Research. Reflexive 
      thematic analysis of semi-structured interviews was conducted within a 
      constructivist-interpretivist research paradigm. Data were organized and managed 
      in NVivo. Techniques to enhance trustworthiness included maintaining an audit 
      trail, member checking, mentoring, and peer-debriefing. Patient and the public 
      were consulted for feedback on codes, themes, and thematic maps. RESULTS: 
      Thirteen participants (median age: 74 years, range: 43-90 years) with a variety 
      of patient demographics were interviewed. Four themes were developed on QOL in 
      CLTI: (i) 'independence as key to life satisfaction', (ii) 'change in identity 
      when continuity is needed', (iii) 'coping with intractable disease', and (iv) 
      'not wanting to be alone'. Member checking with patient and public involvement 
      confirmed the relevance and centrality of these themes to the lived experiences 
      of patients with CLTI. CONCLUSIONS: The thematic outputs contribute important 
      insights into what QOL truly means to patients with CLTI and what matters for 
      their QOL. The content validity of the new CLTI-specific QOL instrument is 
      improved by giving patients voice. This study highlights the value of qualitative 
      inquiry and patient and public involvement in vascular surgical research.
CI  - (c) 2023 Royal Australasian College of Surgeons.
FAU - Shan, Leonard L
AU  - Shan LL
AUID- ORCID: 0000-0003-2162-2565
AD  - Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences, The 
      University of Melbourne, Melbourne, Victoria, Australia.
FAU - Telianidis, Stacey
AU  - Telianidis S
AUID- ORCID: 0000-0001-9049-0389
AD  - Department of Vascular Surgery, St. Vincent's Hospital Melbourne, Melbourne, 
      Victoria, Australia.
FAU - Westcott, Mark J
AU  - Westcott MJ
AD  - Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences, The 
      University of Melbourne, Melbourne, Victoria, Australia.
FAU - Debono, Deborah
AU  - Debono D
AD  - Centre for Health Services Management, School of Public Health, Faculty of 
      Health, University of Technology Sydney, Sydney, New South Wales, Australia.
FAU - Davies, Alun H
AU  - Davies AH
AD  - Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, 
      London, UK.
FAU - Choong, Peter F
AU  - Choong PF
AD  - Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences, The 
      University of Melbourne, Melbourne, Victoria, Australia.
LA  - eng
GR  - Australian Commonwealth Government Research Training Program Scholarship/
GR  - Royal Australasian College of Surgeons Reg Worcester Research Scholarship/
PT  - Journal Article
DEP - 20231127
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Chronic Limb-Threatening Ischemia
MH  - Quality of Life
MH  - Ischemia/surgery
MH  - Vascular Surgical Procedures
MH  - Qualitative Research
MH  - *Peripheral Arterial Disease/surgery
MH  - Treatment Outcome
MH  - Risk Factors
MH  - Limb Salvage
MH  - Chronic Disease
MH  - Retrospective Studies
OTO - NOTNLM
OT  - chronic limb-threatening ischemia
OT  - instrument development
OT  - qualitative
OT  - quality of life
OT  - reflexive thematic analysis
EDAT- 2023/11/28 00:42
MHDA- 2024/03/20 06:45
CRDT- 2023/11/27 22:33
PHST- 2023/11/11 00:00 [revised]
PHST- 2023/09/03 00:00 [received]
PHST- 2023/11/14 00:00 [accepted]
PHST- 2024/03/20 06:45 [medline]
PHST- 2023/11/28 00:42 [pubmed]
PHST- 2023/11/27 22:33 [entrez]
AID - 10.1111/ans.18791 [doi]
PST - ppublish
SO  - ANZ J Surg. 2024 Mar;94(3):429-437. doi: 10.1111/ans.18791. Epub 2023 Nov 27.