PMID- 38014488
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240209
IS  - 2041-6008 (Electronic)
IS  - 2041-5990 (Linking)
VI  - 14
IP  - 11
DP  - 2023 Nov
TI  - Propranolol HCL-loaded liposomes for intranasal delivery: in vitro and ex vivo 
      evaluation of optimized formulation using design of experiments.
PG  - 705-720
LID - 10.4155/tde-2023-0044 [doi]
AB  - Aim: To develop a propranolol HCL-loaded liposomal nasal formulation for migraine 
      prophylaxis. Materials & methods: Formulated the liposomes through thin layer 
      hydration method and optimized via design of experiments (DOE). The prepared 
      liposomes were characterized for particle size, zeta potential, PDI, drug 
      entrapment and drug loading. Assessed for in vitro release kinetics, ex vivo 
      permeability, histopathology and stability. Results: Optimized liposomes: 
      135.52 +/- 5.87 nm, -19.9 +/- 0.075 mV, 95.41 +/- 0.05% entrapment, 43.37 +/- 0.02% 
      loading. Showed immediate (30.07 +/- 2.09%) and sustained release (95.69 +/- 4.58%) 
      over 10 h. Enhanced permeation compared with controls; well-tolerated 
      histopathologically. Conclusion: Liposomal formulation offers promise for 
      intranasal propranolol HCL delivery in migraine prophylaxis, with stability under 
      refrigeration.
FAU - Kumar, Vishal
AU  - Kumar V
AD  - Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi-682041, Kerala, 
      India.
FAU - R, Nethish Kumaar
AU  - R NK
AD  - Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi-682041, Kerala, 
      India.
FAU - Aswin, D
AU  - Aswin D
AD  - Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi-682041, Kerala, 
      India.
FAU - Nair, Sreeja C
AU  - Nair SC
AD  - Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi-682041, Kerala, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20231128
PL  - England
TA  - Ther Deliv
JT  - Therapeutic delivery
JID - 101538870
RN  - 0 (Liposomes)
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
MH  - Humans
MH  - *Liposomes
MH  - Propranolol
MH  - Administration, Intranasal
MH  - Drug Liberation
MH  - *Migraine Disorders
MH  - Particle Size
MH  - Drug Delivery Systems/methods
OAB - Migraines (a type of long-lasting headache) can be helped by a medicine called 
      propranolol HCL. In this study, scientists developed tiny bubbles, called 
      liposomes, which contained propranolol HCL. The liposomes are designed to be 
      inhaled via the nose, where the medicine is released slowly from the liposomes to 
      treat the migraine. In this study, the researchers made the propranolol 
      HCL-containing liposomes and analyzed them in the lab. They found that the 
      liposomes were safe, and can be kept in a cool place for a long time. So, may be 
      able to help treat migraines.
OABL- eng
OTO - NOTNLM
OT  - DOE
OT  - liposome
OT  - migraine
OT  - nose to brain delivery
OT  - particle size
OT  - propranolol HCL
EDAT- 2023/11/28 06:42
MHDA- 2023/12/17 09:42
CRDT- 2023/11/28 04:23
PHST- 2023/12/17 09:42 [medline]
PHST- 2023/11/28 06:42 [pubmed]
PHST- 2023/11/28 04:23 [entrez]
AID - 10.4155/tde-2023-0044 [doi]
PST - ppublish
SO  - Ther Deliv. 2023 Nov;14(11):705-720. doi: 10.4155/tde-2023-0044. Epub 2023 Nov 
      28.