PMID- 38014521
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 14
IP  - 24
DP  - 2023 Dec 11
TI  - Anti-diabetic effects of natural and modified 'Ganzhou' navel orange peel pectin 
      on type 2 diabetic mice via gut microbiota.
PG  - 10977-10990
LID - 10.1039/d3fo04118b [doi]
AB  - Pectin, a kind of dietary fiber, has attracted much attention owing to its 
      beneficial effect on human health in recent years. In this study, the effects of 
      both 'Ganzhou' navel orange peel pectin (GOP) and modified GOP (MGOP) on type 2 
      diabetes (T2DM) were investigated. The results indicated that GOP and MGOP 
      intervention had positive effects on T2DM in C57BL/6 mice. After modification, 
      pectin can be changed into low methoxy pectin (LMP) and the content of GalA can 
      increase, which endow MGOP with significant effects on improving lipid metabolism 
      (TC, TG, and LDL-C decreased by 30.46%, 50%, and 37.56%, respectively, and HDL-C 
      increased by 56%) and OGTT, further reducing insulin resistance (insulin 
      decreased by 74.35%). In addition, MGOP was superior to GOP in improving 
      oxidative stress (GSH and GSH-Px increased by 52.05% and 29.08% respectively, and 
      MDA decreased by 84.02%), inhibiting inflammation and promoting SCFA synthesis. 
      16S rRNA analysis showed that MGOP changed the composition of intestinal 
      microbiota in diabetic mice, decreased the abundance of Alistipes, Helicobacter 
      and Oscillibacter, and increased the relative abundance of Dubosiella, 
      Akkermansiaceae, and Atopobiaceae. The phenotypes of the gut microbiome also 
      changed accordingly, which showed that MGOP significantly inhibited the growth of 
      Gram-negative bacteria and potential pathogenic bacteria and reversed the related 
      complications. Taken together, our findings revealed that MGOP intake regulated 
      lipid metabolism and oxidative stress and improved the gut health of mice, with 
      promising effects against T2DM and related complications.
FAU - Du, Chao
AU  - Du C
AD  - College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, 
      Heilongjiang, 163319, China.
AD  - National Coarse Cereals Engineering Research Center, Daqing, Heilongjiang, China. 
      heibadkcaoyang@163.com.
FAU - Zuo, Feng
AU  - Zuo F
AD  - College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, 
      Heilongjiang, 163319, China.
AD  - National Coarse Cereals Engineering Research Center, Daqing, Heilongjiang, China. 
      heibadkcaoyang@163.com.
FAU - Cao, Yang
AU  - Cao Y
AD  - College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, 
      Heilongjiang, 163319, China.
AD  - National Coarse Cereals Engineering Research Center, Daqing, Heilongjiang, China. 
      heibadkcaoyang@163.com.
FAU - Zang, Yanqing
AU  - Zang Y
AUID- ORCID: 0000-0002-9458-2851
AD  - College of Food Science, Heilongjiang Bayi Agricultural University, Daqing, 
      Heilongjiang, 163319, China.
AD  - National Coarse Cereals Engineering Research Center, Daqing, Heilongjiang, China. 
      heibadkcaoyang@163.com.
LA  - eng
PT  - Journal Article
DEP - 20231211
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 89NA02M4RX (Pectins)
RN  - 0 (RNA, Ribosomal, 16S)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - Pectins/pharmacology
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - *Citrus sinensis
MH  - *Gastrointestinal Microbiome
MH  - *Diabetes Mellitus, Experimental/drug therapy/microbiology
MH  - RNA, Ribosomal, 16S
MH  - Mice, Inbred C57BL
EDAT- 2023/11/28 06:42
MHDA- 2023/12/17 09:42
CRDT- 2023/11/28 04:43
PHST- 2023/12/17 09:42 [medline]
PHST- 2023/11/28 06:42 [pubmed]
PHST- 2023/11/28 04:43 [entrez]
AID - 10.1039/d3fo04118b [doi]
PST - epublish
SO  - Food Funct. 2023 Dec 11;14(24):10977-10990. doi: 10.1039/d3fo04118b.