PMID- 38014535
OWN - NLM
STAT- MEDLINE
DCOM- 20231221
LR  - 20231221
IS  - 1756-8927 (Electronic)
IS  - 1756-8919 (Linking)
VI  - 15
IP  - 24
DP  - 2023 Dec
TI  - Synthesis of 1,3,4-oxadiazoles with 4-methoxynaphthalene ring: discovering new 
      compounds with antimicrobial activity.
PG  - 2239-2255
LID - 10.4155/fmc-2023-0153 [doi]
AB  - Background: Paracoccidioidomycosis (PCM) is a systemic infection caused by 
      Paracoccidioides spp. (Pb). PCM can be associated or clinically confused with 
      tuberculosis (TB), another pulmonary infection, caused by Mycobacterium 
      tuberculosis (Mtb). Futhermore, the long treatment time of TB and PCM and the 
      cases of TB drug resistance impose difficulties for the cure of these diseases. 
      Results: New 1,3,4-oxadiazoles containing the 4-methoxynaphthalene ring were 
      synthesized and their antimicrobial activity was evaluated against Pb and Mtb. 
      The derivative 6n (with 2-hydroxy-5-nitrophenyl subunit) is the most promising of 
      the series. Conclusion: The 1,3,4-oxadiazole 6n can be used as a prototype drug 
      candidate, with anti-Pb and anti-MTb activities, showing a broad-spectrum profile 
      for the treatment of both pulmonary infections.
FAU - Frederico Rozada, Andrew Matheus
AU  - Frederico Rozada AM
AUID- ORCID: 0000-0001-8151-7949
AD  - Chemistry Department, State University of Maringa, PR, 87020-900, Brazil.
FAU - Vilugron Rodrigues-Vendramini, Franciele Abigail
AU  - Vilugron Rodrigues-Vendramini FA
AUID- ORCID: 0000-0002-1850-8975
AD  - Department of Clinical Analysis & Biomedicine, Laboratory of Medical Mycology, 
      State University of Maringa, Maringa, PR, 87020-900, Brazil.
FAU - Kioshima, Erika Seki
AU  - Kioshima ES
AUID- ORCID: 0000-0003-3290-8577
AD  - Department of Clinical Analysis & Biomedicine, Laboratory of Medical Mycology, 
      State University of Maringa, Maringa, PR, 87020-900, Brazil.
FAU - Sampiron, Eloisa Gibin
AU  - Sampiron EG
AUID- ORCID: 0000-0002-4337-0007
AD  - Postgraduate Program in Health Sciences, State University of Maringa, Maringa, 
      PR, 87020-900, Brazil.
FAU - de Lima Scodro, Regiane Bertin
AU  - de Lima Scodro RB
AUID- ORCID: 0000-0002-9129-2445
AD  - Department of Clinical Analysis & Biomedicine, State University of Maringa, 
      Maringa, PR, 87020-900, Brazil.
FAU - Caleffi-Ferracioli, Katiany Rizzieri
AU  - Caleffi-Ferracioli KR
AUID- ORCID: 0000-0003-0345-1600
AD  - Department of Clinical Analysis & Biomedicine, State University of Maringa, 
      Maringa, PR, 87020-900, Brazil.
FAU - Vicente Seixas, Flavio Augusto
AU  - Vicente Seixas FA
AUID- ORCID: 0000-0002-0117-6919
AD  - Department of Technology, State University of Maringa, Umuarama, PR, 87506-370, 
      Brazil.
FAU - Basso, Ernani Abicht
AU  - Basso EA
AUID- ORCID: 0000-0001-7554-5206
AD  - Chemistry Department, State University of Maringa, PR, 87020-900, Brazil.
FAU - Freitas Gauze, Gisele de
AU  - Freitas Gauze G
AUID- ORCID: 0000-0002-1971-1983
AD  - Chemistry Department, State University of Maringa, PR, 87020-900, Brazil.
LA  - eng
GR  - 404455/2016-6/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/
PT  - Journal Article
DEP - 20231128
PL  - England
TA  - Future Med Chem
JT  - Future medicinal chemistry
JID - 101511162
RN  - 0 (Oxadiazoles)
RN  - 2P299V784P (Lead)
RN  - 0 (Anti-Infective Agents)
SB  - IM
MH  - Humans
MH  - Oxadiazoles/pharmacology
MH  - Lead/therapeutic use
MH  - *Mycobacterium tuberculosis
MH  - *Tuberculosis/drug therapy
MH  - *Paracoccidioidomycosis/drug therapy/microbiology
MH  - *Anti-Infective Agents/pharmacology/therapeutic use
OTO - NOTNLM
OT  - 1-3-4-oxadiazoles
OT  - 4-methoxynaphthalene
OT  - co-infection
OT  - paracoccidioidomycosis
OT  - tuberculosis
EDAT- 2023/11/28 06:42
MHDA- 2023/12/21 06:42
CRDT- 2023/11/28 05:27
PHST- 2023/12/21 06:42 [medline]
PHST- 2023/11/28 06:42 [pubmed]
PHST- 2023/11/28 05:27 [entrez]
AID - 10.4155/fmc-2023-0153 [doi]
PST - ppublish
SO  - Future Med Chem. 2023 Dec;15(24):2239-2255. doi: 10.4155/fmc-2023-0153. Epub 2023 
      Nov 28.