PMID- 38016312
OWN - NLM
STAT- MEDLINE
DCOM- 20240208
LR  - 20240213
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 465
DP  - 2024 Mar 5
TI  - Novel insights into aerobic 17beta-estradiol degradation by enriched microbial 
      communities from mangrove sediments.
PG  - 133045
LID - S0304-3894(23)02329-4 [pii]
LID - 10.1016/j.jhazmat.2023.133045 [doi]
AB  - Various persistent organic pollutants (POPs) including estrogens are often 
      enriched in mangrove regions. This research investigated the estrogens pollution 
      levels in six mangroves located in the Southern China. The estrogen levels were 
      found to be in the range of 5.3-24.9 ng/g dry weight, suggesting that these 
      mangroves had been seriously contaminated. The bacterial communities under 
      estrogen stress were further enriched by supplementing 17beta-estradiol (E2) as the 
      sole carbon source. The enriched bacterial communities showed an excellent E2 
      degradation capacity > 95 %. These communities were able to transform E2 into 
      estrone (E1), 4-hydroxy-estrone, and keto-estrone, etc. 16 S rDNA sequencing and 
      metagenomics analysis revealed that bacterial taxa Oleiagrimonas, Pseudomonas, 
      Terrimonas, and Nitratireductor etc. were the main contributors to estrogen 
      degradation. Moreover, the genes involved in E2 degradation were enriched in the 
      microbial communities, including the genes encoding 17beta-hydroxysteroid 
      dehydrogenase, estrone 4-hydroxylase, etc. Finally, the analyses of functional 
      genes and binning genomes demonstrated that E2 was degraded by bacterial 
      communities via dehydrogenation into E1 by 17beta-hydroxysteroid dehydrogenase. E1 
      was then catabolically converted to 
      3aalpha-H-4alpha(3'-propanoate)- 7abeta-methylhexahydro-1,5-indanedione via 4,5-seco 
      pathway. Alternatively, E1 could also be hydroxylated to keto-estrone, followed 
      by B-ring cleavage. This study provides novel insights into the biodegradation of 
      E2 by the bacterial communities in estrogen-contaminated mangroves.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Zhang, Shan
AU  - Zhang S
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China.
FAU - Ye, Xueying
AU  - Ye X
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China; 
      School of Life Sciences, Huizhou University, Huizhou 510607, China.
FAU - Lin, Xianbin
AU  - Lin X
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China.
FAU - Zeng, Xiangwei
AU  - Zeng X
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China.
FAU - Meng, Shanshan
AU  - Meng S
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China.
FAU - Luo, Wenqi
AU  - Luo W
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China.
FAU - Yu, Fei
AU  - Yu F
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China.
FAU - Peng, Tao
AU  - Peng T
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China.
FAU - Huang, Tongwang
AU  - Huang T
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China.
FAU - Li, Jin
AU  - Li J
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China; 
      College of Life Sciences, China West Normal University, Nanchong 637002, China. 
      Electronic address: jinli2023@cwnu.edu.cn.
FAU - Hu, Zhong
AU  - Hu Z
AD  - Department of Biology, Shantou University, Shantou, Guangdong 515063, China. 
      Electronic address: hzh@stu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231124
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 2DI9HA706A (Estrone)
RN  - 4TI98Z838E (Estradiol)
RN  - 0 (Estrogens)
SB  - IM
MH  - *Estrone/metabolism
MH  - *Estradiol/metabolism
MH  - Estrogens/analysis
MH  - Biodegradation, Environmental
MH  - Bacteria/metabolism
OTO - NOTNLM
OT  - 17beta-estradiol degradation
OT  - Estrogen contamination
OT  - Mangroves
OT  - Microbial community
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/29 00:42
MHDA- 2024/02/08 06:42
CRDT- 2023/11/28 18:07
PHST- 2023/08/04 00:00 [received]
PHST- 2023/10/13 00:00 [revised]
PHST- 2023/11/18 00:00 [accepted]
PHST- 2024/02/08 06:42 [medline]
PHST- 2023/11/29 00:42 [pubmed]
PHST- 2023/11/28 18:07 [entrez]
AID - S0304-3894(23)02329-4 [pii]
AID - 10.1016/j.jhazmat.2023.133045 [doi]
PST - ppublish
SO  - J Hazard Mater. 2024 Mar 5;465:133045. doi: 10.1016/j.jhazmat.2023.133045. Epub 
      2023 Nov 24.