PMID- 38016412
OWN - NLM
STAT- MEDLINE
DCOM- 20240129
LR  - 20240212
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 136
DP  - 2024 Jan
TI  - The molecular landscape of myeloproliferative neoplasms associated with 
      splanchnic vein thrombosis: Current perspective.
PG  - 107420
LID - S0145-2126(23)00685-9 [pii]
LID - 10.1016/j.leukres.2023.107420 [doi]
AB  - BCR::ABL1-negative myeloproliferative neoplasms (MPNs) are classically 
      represented by polycythemia vera, essential thrombocythemia, and primary 
      myelofibrosis. BCR::ABL1-negative MPNs are significantly associated with 
      morbidity and mortality related to an increased risk of thrombo-hemorrhagic 
      events. They show a consistent association with splanchnic vein thrombosis (SVT), 
      either represented by the portal, mesenteric or splenic vein thrombosis, or 
      Budd-Chiari Syndrome. SVT is also a frequent presenting manifestation of MPN. 
      MPNs associated with SVT show a predilection for younger women, high association 
      with JAK2V617F mutation, low JAK2V617F variant allele frequency (generally <10 
      %), and low rates of CALR, MPL, or JAK2 exon 12 mutations. Next-Generation 
      Sequencing techniques have contributed to deepening our knowledge of the 
      molecular landscape of such cases, with potential diagnostic and prognostic 
      implications. In this narrative review, we analyze the current perspective on the 
      molecular background of MPN associated with SVT, pointing as well future 
      directions in this field.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Pescia, Carlo
AU  - Pescia C
AD  - Unit of Anatomic Pathology, Foundation IRCCS Ca' Granda Ospedale Maggiore 
      Policlinico, Milan, Italy. Electronic address: carlo.pescia@unimi.it.
FAU - Lopez, Gianluca
AU  - Lopez G
AD  - Unit of Anatomic Pathology, Foundation IRCCS Ca' Granda Ospedale Maggiore 
      Policlinico, Milan, Italy; Department of Biomedical, Surgical and Dental 
      Sciences, University of Milan, Italy.
FAU - Cattaneo, Daniele
AU  - Cattaneo D
AD  - Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, 
      Milan, Italy.
FAU - Bucelli, Cristina
AU  - Bucelli C
AD  - Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy.
FAU - Gianelli, Umberto
AU  - Gianelli U
AD  - Department of Health Sciences, University of Milan, Milan, Italy; Unit of 
      Anatomic Pathology, ASST Santi Paolo e Carlo, Milan, Italy.
FAU - Iurlo, Alessandra
AU  - Iurlo A
AD  - Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20231110
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Calreticulin)
RN  - EC 2.7.10.2 (Janus Kinase 2)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Myeloproliferative Disorders/complications/genetics/diagnosis
MH  - *Venous Thrombosis/genetics
MH  - *Polycythemia Vera/complications
MH  - *Thrombocythemia, Essential/genetics
MH  - Mutation
MH  - Calreticulin/genetics
MH  - Janus Kinase 2/genetics
OTO - NOTNLM
OT  - Molecular biology
OT  - Myeloid neoplasms
OT  - Myeloproliferative neoplasms
OT  - Splanchnic vein thrombosis
COIS- Declaration of Competing Interest U.G. received fees from Novartis Farma S.p.A. 
      and Jazz Pharma as a consultant speaker and advisory board. A.I. and D.C. receive 
      speaker honoraria from Novartis Farma S.p.A. All other authors declare no 
      conflict of interest.
EDAT- 2023/11/29 00:42
MHDA- 2024/01/29 06:43
CRDT- 2023/11/28 18:11
PHST- 2023/06/26 00:00 [received]
PHST- 2023/10/30 00:00 [revised]
PHST- 2023/11/03 00:00 [accepted]
PHST- 2024/01/29 06:43 [medline]
PHST- 2023/11/29 00:42 [pubmed]
PHST- 2023/11/28 18:11 [entrez]
AID - S0145-2126(23)00685-9 [pii]
AID - 10.1016/j.leukres.2023.107420 [doi]
PST - ppublish
SO  - Leuk Res. 2024 Jan;136:107420. doi: 10.1016/j.leukres.2023.107420. Epub 2023 Nov 
      10.