PMID- 38017473
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 1750-9378 (Print)
IS  - 1750-9378 (Electronic)
IS  - 1750-9378 (Linking)
VI  - 18
IP  - 1
DP  - 2023 Nov 28
TI  - Elucidating the clonal relationship of esophageal second primary tumors in 
      patients with laryngeal squamous cell carcinoma.
PG  - 75
LID - 10.1186/s13027-023-00558-z [doi]
LID - 75
AB  - Laryngeal cancer ranks as the second most prevalent upper airway malignancy, 
      following Lung cancer. Although some progress has been made in managing laryngeal 
      cancer, the 5-year survival rate is disappointing. The gradual increase in the 
      incidence of second primary tumors (SPTs) plays a crucial role in determining 
      survival outcomes during long-term follow-up, and the esophagus was the most 
      common site with a worse prognosis. In clinical practice, the treatment of 
      esophageal second primary tumors (ESPT) in patients with laryngeal squamous cell 
      carcinoma (LSCC) has always been challenging. For patients with synchronous 
      tumors, several treatment modalities, such as radiotherapy, chemotherapy and 
      potentially curative surgery are necessary but are typically poorly tolerated. 
      Secondary cancer therapy options for metachronous patients are always constrained 
      by index cancer treatment indications. Therefore, understanding the clonal origin 
      of the second primary tumor may be an important issue in the treatment of 
      patients. LSCC cells demonstrate genetic instability because of two distinct 
      aetiologies (human papillomavirus (HPV)-negative and HPV-positive) disease. 
      Various etiologies exhibit distinct oncogenic mechanisms, which subsequently 
      impact the tissue microenvironment. The condition of the tissue microenvironment 
      plays a crucial role in determining the destiny and clonal makeup of mutant cells 
      during the initial stages of tumorigenesis. This review focuses on the genetic 
      advances of LSCC, the current research status of SPT, and the influence of key 
      carcinogenesis of HPV-positive and HPV-negative LSCC on clonal evolution of ESPT 
      cells. The objective is to gain a comprehensive understanding of the molecular 
      basis underlying the clonal origins of SPT, thereby offering novel perspectives 
      for future investigations in this field.
CI  - (c) 2023. The Author(s).
FAU - Wan, Meixuan
AU  - Wan M
AD  - Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, 
      150081, China.
FAU - Yang, Xinxin
AU  - Yang X
AD  - Precision Medicine Center, Harbin Medical University Cancer Hospital, Harbin, 
      150081, China.
FAU - He, Lin
AU  - He L
AD  - Department of Stomatology, Heilongjiang Province Hospital, Harbin, 150081, China.
FAU - Meng, Hongxue
AU  - Meng H
AD  - Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, 
      150081, China. menghongxue@hrbmu.edu.cn.
AD  - Precision Medicine Center, Harbin Medical University Cancer Hospital, Harbin, 
      150081, China. menghongxue@hrbmu.edu.cn.
LA  - eng
GR  - 82072985/National Nature Science Foundation of China/
GR  - LBH-Q18076/Postdoctoral Scientific. Research Developmental Fund of Heilongjiang 
      Province/
GR  - 2017-03/N10 Found project of Harbin Medical University Cancer Hospital/
GR  - JCQN-2018-05/Outstanding Youth Foundation of Harbin Medical University Cancer 
      Hospital/
GR  - YQ2020H036/National Nature Science Foundation of Heilongjiang Province/
GR  - 2020GSP04/Special funds of central finance to support the development of local 
      University/
GR  - 320.6750.19089-22,320.6750.19089-48/Wu-Jieping Medical Foundation/
GR  - YXJL-2019-1416-0069/Beijing Medical Award Foundation/
GR  - JJQN2021-02/Hai Yan Youth Fund of Harbin Medical University Cancer Hospital/
GR  - 2021-KYYWF-0253/Fund amental Research Funds for the Provincial Universities/
GR  - LH2022H065/Natural Science Foundation of Heilongjiang Province/
PT  - Journal Article
PT  - Review
DEP - 20231128
PL  - England
TA  - Infect Agent Cancer
JT  - Infectious agents and cancer
JID - 101276559
PMC - PMC10685475
OTO - NOTNLM
OT  - Clone
OT  - Epigenetics
OT  - Esophageal second primary tumor
OT  - Field cancerization
OT  - Laryngeal squamous cell carcinoma
OT  - Tumor microenvironment
COIS- The authors declare that they have no competing interests.
EDAT- 2023/11/29 06:42
MHDA- 2023/11/29 06:43
PMCR- 2023/11/28
CRDT- 2023/11/29 00:08
PHST- 2023/09/01 00:00 [received]
PHST- 2023/11/09 00:00 [accepted]
PHST- 2023/11/29 06:43 [medline]
PHST- 2023/11/29 06:42 [pubmed]
PHST- 2023/11/29 00:08 [entrez]
PHST- 2023/11/28 00:00 [pmc-release]
AID - 10.1186/s13027-023-00558-z [pii]
AID - 558 [pii]
AID - 10.1186/s13027-023-00558-z [doi]
PST - epublish
SO  - Infect Agent Cancer. 2023 Nov 28;18(1):75. doi: 10.1186/s13027-023-00558-z.