PMID- 38018046
OWN - NLM
STAT- MEDLINE
DCOM- 20231130
LR  - 20231130
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 61
IP  - 12
DP  - 2023 Dec 2
TI  - [Clinical and imaging features of infective sacroiliitis in children].
PG  - 1092-1097
LID - 10.3760/cma.j.cn112140-20230825-00131 [doi]
AB  - Objective: To summarize the clinical, radiological characteristics, and prognosis 
      of infectious sacroiliitis in children. Methods: A case-control study was 
      conducted, including 12 cases of infectious sacroiliitis diagnosed in the 
      Rheumatology and Immunology Department of the Children's Hospital affiliated with 
      the Capital Institute of Pediatrics from June 2018 to June 2023. These cases 
      comprised the case group. Concurrently, 28 cases of pediatric idiopathic 
      arthritis involving the sacroiliac joint in the same department served as the 
      control group. Basic patient information, clinical features, laboratory 
      parameters, and clinical treatment outcomes for both groups were collected and 
      analyzed. Independent sample t-tests and chi-squared tests were used for 
      inter-group comparisons. Results: Among the 12 cases in the case group, there 
      were 5 males and 7 females, with a disease duration of 0.8 (0.5, 1.2) months. 
      Nine patients presented with fever, and 1 patient had limping gait. Human 
      leukocyte antigen (HLA)-B27 positivity was observed in 1 case, and there was no 
      family history of ankylosing spondylitis. In the control group of 28 cases, there 
      were 19 males and 9 females, with a disease duration of 7.0 (3.0, 17.0) months. 
      One patient (4%) had fever, and 14 cases (50%) exhibited limping gait. HLA-B27 
      positivity was found in 18 cases (64%), and 18 cases (64%) had a family history 
      of ankylosing spondylitis. The case group had higher white blood cell count 
      (WBC), neutrophil ratio, erythrocyte sedimentation rate (ESR), C-reactive protein 
      (CRP) levels, as well as a higher proportion of unilateral involvement on 
      magnetic resonance imaging and bone destruction on CT compared to the control 
      group ((11.1+/-6.2)x10(9) vs. (7.3+/-2.3)x10(9)/L, 0.64+/-0.10 vs. 0.55+/-0.12, 72 (34, 
      86) vs. 18 (5, 41) mm/1 h, 24.6 (10.1, 67.3) mg/L vs. 3.6 (0.8, 15.0) mg/L, 11/12 
      vs. 36% (10/28), 9/12 vs. 11% (3/28), t=2.90, 3.07, Z=-2.94, -3.28, chi(2)=10.55, 
      16.53, all P<0.05). Conclusions: Pediatric infectious sacroiliitis often presents 
      as unilateral involvement with a short disease history. Elevated WBC, CRP, and 
      ESR, as well as a high rate of bone destruction, are also common characteristics.
FAU - Yue, T
AU  - Yue T
AD  - Department of Rheumatology and Immunology, Children's Hospital Capital Institute 
      of Pediatrics, Beijing 100020, China.
FAU - Lai, J M
AU  - Lai JM
AD  - Department of Rheumatology and Immunology, Children's Hospital Capital Institute 
      of Pediatrics, Beijing 100020, China.
FAU - Yang, Y
AU  - Yang Y
AD  - Department of Radiology, Children's Hospital Capital Institute of Pediatrics, 
      Beijing 100020, China.
FAU - Zhang, D
AU  - Zhang D
AD  - Department of Rheumatology and Immunology, Children's Hospital Capital Institute 
      of Pediatrics, Beijing 100020, China.
FAU - Su, G X
AU  - Su GX
AD  - Department of Rheumatology and Immunology, Children's Hospital Capital Institute 
      of Pediatrics, Beijing 100020, China.
FAU - Zhu, J
AU  - Zhu J
AD  - Department of Rheumatology and Immunology, Children's Hospital Capital Institute 
      of Pediatrics, Beijing 100020, China.
FAU - Wu, F Q
AU  - Wu FQ
AD  - Department of Rheumatology and Immunology, Children's Hospital Capital Institute 
      of Pediatrics, Beijing 100020, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Child
MH  - *Sacroiliitis/diagnostic imaging
MH  - *Spondylitis, Ankylosing/diagnosis
MH  - Case-Control Studies
MH  - Sacroiliac Joint/diagnostic imaging
MH  - Radiography
MH  - Magnetic Resonance Imaging
MH  - Fever
EDAT- 2023/11/29 06:42
MHDA- 2023/11/30 06:42
CRDT- 2023/11/29 02:38
PHST- 2023/11/30 06:42 [medline]
PHST- 2023/11/29 06:42 [pubmed]
PHST- 2023/11/29 02:38 [entrez]
AID - 10.3760/cma.j.cn112140-20230825-00131 [doi]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2023 Dec 2;61(12):1092-1097. doi: 
      10.3760/cma.j.cn112140-20230825-00131.