PMID- 38018214
OWN - NLM
STAT- Publisher
LR  - 20231129
IS  - 2212-4020 (Electronic)
IS  - 1872-2105 (Linking)
DP  - 2023 Nov 7
TI  - Emerging Treatment Options of Pluronic in Designing Colloidal Nano and 
      Microcarriers Carriers for Various Therapies.
LID - 10.2174/0118722105255391231018112747 [doi]
AB  - Poloxamers, commonly known as Pluronics, are a special family of synthetic 
      tri-block copolymers with a core structure made of hydrophobic poly (propylene 
      oxide) chains sandwiched by two hydrophilic poly (ethylene oxide) chains. It is 
      possible to modify the mechanical, bioactive, and microstructural characteristics 
      of Pluronics to simulate the behavior of different types of tissues. 
      Additionally, they are auspicious drug carriers with the capacity to increase 
      therapeutic agent availability and to design nano-drug formulations for various 
      ailments. The nanoformulation composed of Pluronics is more susceptible to cancer 
      cells due to their amphiphilic nature and feature of selfassembling into 
      micelles. Today's expanding poloxamer research is creating new hopes that 
      increase the possibility of new remedies for a brand-new nanomedicine age 
      treatment. This article provides a concise overview of the classification, 
      grading, and attributes of drug delivery systems (DDSs) as well as the potential 
      for Pluronics to create micro and nanocarriers. We subsequently discuss its 
      utility in drug delivery for cancer, gene therapy, anti-infective therapy, 
      antioxidants, anti-diabetic drugs, anti-HIV, Alzheimer's disease, and 
      antimicrobial drugs. This review also highlighted several patented formulations 
      that contain various grades of Pluronics in one or more different ways. The 
      recent findings in fundamental research in the field properly demonstrate the 
      strong interest in these novel pharmaceutical strategies.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Mathur, Pooja
AU  - Mathur P
AD  - Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka 
      University, Gurugram-122103, Haryana, India.
FAU - Verma, Ravinder
AU  - Verma R
AUID- ORCID: 0000-0003-3397-703X
AD  - Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani 
      (Haryana), 127021, India.
FAU - Rani, Laxmi
AU  - Rani L
AD  - Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka 
      University, Gurugram-122103, Haryana, India.
FAU - Kamboj, Sweta
AU  - Kamboj S
AD  - Guru Gobind Singh College of Pharmacy, Yamuna Nagar-135001, Haryana, India.
FAU - Kamboj, Rohit
AU  - Kamboj R
AD  - Guru Gobind Singh College of Pharmacy, Yamuna Nagar-135001, Haryana, India.
FAU - Kamboj, Tanu
AU  - Kamboj T
AD  - Guru Gobind Singh College of Pharmacy, Yamuna Nagar-135001, Haryana, India.
FAU - Bhatt, Shailendra
AU  - Bhatt S
AD  - Shrinathji Institute of Pharmacy, Shrinathji Society for Higher Education, Upali 
      Oden, Nathdwara, Rajasmand, Rajasthan, India.
LA  - eng
PT  - Journal Article
DEP - 20231107
PL  - United Arab Emirates
TA  - Recent Pat Nanotechnol
JT  - Recent patents on nanotechnology
JID - 101291922
SB  - IM
OTO - NOTNLM
OT  - Poloxamer
OT  - advanced nano-drug.
OT  - cancer
OT  - gene therapy
OT  - nanomedicine
OT  - patent
OT  - pluronics
EDAT- 2023/11/29 06:43
MHDA- 2023/11/29 06:43
CRDT- 2023/11/29 03:44
PHST- 2023/03/28 00:00 [received]
PHST- 2023/08/14 00:00 [revised]
PHST- 2023/09/01 00:00 [accepted]
PHST- 2023/11/29 06:43 [medline]
PHST- 2023/11/29 06:43 [pubmed]
PHST- 2023/11/29 03:44 [entrez]
AID - NANOTEC-EPUB-135963 [pii]
AID - 10.2174/0118722105255391231018112747 [doi]
PST - aheadofprint
SO  - Recent Pat Nanotechnol. 2023 Nov 7. doi: 10.2174/0118722105255391231018112747.