PMID- 38020453 OWN - NLM STAT- MEDLINE DCOM- 20231201 LR - 20231201 IS - 1178-1998 (Electronic) IS - 1176-9092 (Print) IS - 1176-9092 (Linking) VI - 18 DP - 2023 TI - Triglyceride Glucose Index is Strongly Associated with a Fragility Fracture in Postmenopausal Elderly Females with Type 2 Diabetes Mellitus Combined with Osteoporosis: A 6-Year Follow-Up Study. PG - 1841-1849 LID - 10.2147/CIA.S434194 [doi] AB - PURPOSE: The triglyceride glucose (TyG) index serves as an indicator of insulin resistance (IR), which is also associated with bone metabolism. However, research on the relationship between the TyG index and a fragility fracture in individuals with type 2 diabetes mellitus (T2DM) or osteoporosis (OP) remains sparse. This study aims to explore the association between the TyG index and fragility fracture risk in postmenopausal elderly females with T2DM combined with OP based on an ambispective cohort study. PATIENTS AND METHODS: A total of 220 postmenopausal women hospitalized with T2DM combined with OP between January 2015 and December 2020 were eligible for inclusion in this study. All participants were followed up every 6 months for 6 years with a median of 42 months. According to the tertiles of the TyG index, participants were divided into three groups: low-level (/= 9.33, n=74). The association between the TyG index and fragility fracture risk was then assessed. RESULTS: Out of 220 patients, 46 experienced fragility fracture events (20.9%). Multivariate Cox regression analysis showed that the TyG index was positively associated with a fragility fracture in postmenopausal women with T2DM combined with OP. Furthermore, compared to the low-level group, with the TyG index level increase by 1.0, the risk for fragility fracture increased 1.293-fold in the high-level group (HR=2.293, 95% CI=1.007-5.221, P < 0.05). Kaplan-Meier survival analysis indicated that fragility fractures were more likely to occur in patients with high levels of TyG index (log-rank, all P < 0.05). CONCLUSION: Our study showed that the TyG index was strongly associated with a fragility fracture in postmenopausal women with T2DM combined with OP. Therefore, special attention should be paid to postmenopausal elderly females with T2DM combined with OP in routine clinical practice. CI - (c) 2023 Pan et al. FAU - Pan, Jiangmei AU - Pan J AD - Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China. AD - Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, People's Republic of China. FAU - Huang, Xiuxian AU - Huang X AD - Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China. FAU - Wang, Qiu AU - Wang Q AD - Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China. FAU - Sun, Jingxia AU - Sun J AD - Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China. FAU - Zhai, Zhenwei AU - Zhai Z AD - Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China. FAU - Mo, Jiacheng AU - Mo J AUID- ORCID: 0009-0001-5303-2693 AD - Information Network Center of Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China. FAU - Huang, Jianhao AU - Huang J AD - Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China. FAU - Lu, Wensheng AU - Lu W AUID- ORCID: 0000-0002-0212-3624 AD - Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, People's Republic of China. LA - eng PT - Journal Article DEP - 20231109 PL - New Zealand TA - Clin Interv Aging JT - Clinical interventions in aging JID - 101273480 RN - IY9XDZ35W2 (Glucose) RN - 0 (Triglycerides) RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Aged MH - *Diabetes Mellitus, Type 2/complications/metabolism MH - Glucose MH - Follow-Up Studies MH - Risk Factors MH - Cohort Studies MH - Triglycerides MH - Postmenopause MH - Blood Glucose/metabolism MH - *Osteoporosis/complications MH - *Fractures, Bone MH - Biomarkers PMC - PMC10643234 OTO - NOTNLM OT - fragility fracture OT - osteoporosis OT - triglyceride glucose index OT - type 2 diabetes mellitus COIS- The authors report no conflicts of interest in this work. EDAT- 2023/11/29 18:42 MHDA- 2023/12/01 06:45 PMCR- 2023/11/09 CRDT- 2023/11/29 14:43 PHST- 2023/08/06 00:00 [received] PHST- 2023/11/05 00:00 [accepted] PHST- 2023/12/01 06:45 [medline] PHST- 2023/11/29 18:42 [pubmed] PHST- 2023/11/29 14:43 [entrez] PHST- 2023/11/09 00:00 [pmc-release] AID - 434194 [pii] AID - 10.2147/CIA.S434194 [doi] PST - epublish SO - Clin Interv Aging. 2023 Nov 9;18:1841-1849. doi: 10.2147/CIA.S434194. eCollection 2023.