PMID- 38020484
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 2054-3581 (Print)
IS  - 2054-3581 (Electronic)
IS  - 2054-3581 (Linking)
VI  - 10
DP  - 2023
TI  - Association Between Arterial Stiffness and Measures of Autonomic Dysfunction in 
      People With Chronic Kidney Disease.
PG  - 20543581231213798
LID - 10.1177/20543581231213798 [doi]
LID - 20543581231213798
AB  - BACKGROUND: Autonomic nervous system (ANS) dysfunction and vascular stiffness 
      increase cardiovascular risk in people with chronic kidney disease (CKD). Chronic 
      elevations in sympathetic activity can lead to increased arterial stiffness; 
      however, the relationship between these variables is unknown in CKD. OBJECTIVE: 
      To explore the association between measures of autonomic function and arterial 
      stiffness in patients with moderate-to-severe CKD. METHODS: This study was a 
      prespecified secondary analysis of a randomized controlled trial. This included 
      the following measures: 24-hour ambulatory blood pressure (BP), carotid-femoral 
      and carotid-radial pulse wave velocity (PWV), and postexercise heart rate 
      recovery (HRR). We used mixed effect linear regression models with Bayesian 
      information criteria (BIC) to assess the contribution of ANS measurements. 
      RESULTS: Forty-four patients were included in the analysis. Mean carotid-femoral 
      and carotid-radial PWV were 7.12 m/s (95% CI 6.13, 8.12) and 8.51 m/s (7.90, 
      9.11), respectively. Mean systolic dipping, calculated as percentage change in 
      mean systolic readings from day to night, was 10.0% (95% CI 7.79, 12.18). 
      Systolic dipping was independently associated with carotid-radial PWV, MD -0.09 
      m/s (95% CI -0.15, -0.02) and had the lowest BIC. CONCLUSIONS: Systolic dipping 
      was associated with carotid-radial PWV in people with moderate-to-severe CKD; 
      however, there was no association with carotid-femoral PWV. Systolic dipping may 
      be a feasible surrogate of ANS function, as the association with carotid-radial 
      PWV was consistent with the minimal clinically important difference (MCID). 
      Future studies are needed to define the relationship between ANS function, 
      arterial stiffness, and CV events over time in people with CKD.
CI  - (c) The Author(s) 2023.
FAU - Davies, Rachelle
AU  - Davies R
AUID- ORCID: 0000-0002-4054-9861
AD  - Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, 
      Canada.
FAU - Wiebe, Natasha
AU  - Wiebe N
AUID- ORCID: 0000-0002-5613-1582
AD  - Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, 
      Canada.
FAU - Brotto, Andrew
AU  - Brotto A
AD  - Division of Pulmonary Medicine, Department of Medicine, University of Alberta, 
      Edmonton, Canada.
FAU - Stickland, Michael K
AU  - Stickland MK
AD  - Division of Pulmonary Medicine, Department of Medicine, University of Alberta, 
      Edmonton, Canada.
FAU - Braam, Branko
AU  - Braam B
AD  - Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, 
      Canada.
FAU - Thompson, Stephanie
AU  - Thompson S
AUID- ORCID: 0000-0003-3109-6837
AD  - Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, 
      Canada.
LA  - eng
PT  - Journal Article
DEP - 20231121
PL  - England
TA  - Can J Kidney Health Dis
JT  - Canadian journal of kidney health and disease
JID - 101640242
PMC - PMC10664430
OTO - NOTNLM
OT  - arterial stiffness
OT  - autonomic dysfunction
OT  - blood pressure variability
OT  - chronic kidney disease
OT  - systolic dipping
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:43
PMCR- 2023/11/21
CRDT- 2023/11/29 14:44
PHST- 2023/06/01 00:00 [received]
PHST- 2023/10/15 00:00 [accepted]
PHST- 2023/11/29 18:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 14:44 [entrez]
PHST- 2023/11/21 00:00 [pmc-release]
AID - 10.1177_20543581231213798 [pii]
AID - 10.1177/20543581231213798 [doi]
PST - epublish
SO  - Can J Kidney Health Dis. 2023 Nov 21;10:20543581231213798. doi: 
      10.1177/20543581231213798. eCollection 2023.