PMID- 38020577
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 1179-142X (Print)
IS  - 1179-142X (Electronic)
IS  - 1179-142X (Linking)
VI  - 16
DP  - 2023
TI  - A Case of ALK-Positive Anaplastic Large Cell Lymphoma of the Male Breast.
PG  - 747-755
LID - 10.2147/IMCRJ.S434109 [doi]
AB  - BACKGROUND: Primary breast lymphoma (PBL) is a very rare form of non-Hodgkin's 
      lymphoma (NHL). A primary T-cell lymphoma in the breast with no previously 
      identified lymphomatous lesions is an even rarer form of this malignancy. CASE 
      PRESENTATION: A biopsy of a breast mass in a 60-year-old Caucasian man showed a 
      morphologic-immunophenotypic profile with features characteristic of an 
      ALK-positive (AKT+), anaplastic large cell lymphoma. Fluorescence in situ 
      hybridization (FISH) analysis of fixed, paraffin-embedded tissue of this lesion 
      was performed at our institution for IRF4/DUSP22 gene rearrangement. No 
      rearrangement was detected. The patient presented with mutations in the following 
      genes; BCOR_p.Q600X, DNMT3A_p.F609fs, NOTCH1_p.P2320fs, and IDH2_p.R140Q. 
      However, the patient's consultation was complicated by the fact that he had been 
      diagnosed with breast cancer at a local hospital and had come to our institution 
      for further consultation. The histology findings were confirmed by 
      immunohistochemistry and FISH. Computed tomography and positron emission 
      tomography did not reveal nodules elsewhere in the body, which allowed the 
      staging of the patient to be completed. However, although the patient had 
      previously received the chemotherapy CCOP regimen (ie, cyclophosphamide, 
      vincristine, prednisolone acetate) he did not go into remission in a timely 
      manner and relapsed after six months, followed by a drastic deterioration in his 
      condition after four months, resulting in his death in less than one month. 
      CONCLUSION: This report of a male patient describes a case of a rare T-cell 
      lymphoma of the breast that occurs considerably more frequently in female 
      patients. The differential diagnosis of the histology of this tumor showed 
      mutations that occur more often in lymphoblastic lymphoma or leukemia. This rare 
      malignancy and associated mutations led to the death of this patient during 
      treatment.
CI  - (c) 2023 Wang et al.
FAU - Wang, Xu
AU  - Wang X
AD  - Department of Pathology, the Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050011, People's Republic of China.
FAU - Jia, Zhanli
AU  - Jia Z
AD  - Department of Pathology, the Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050011, People's Republic of China.
FAU - Li, Jinze
AU  - Li J
AD  - Department of Pathology, the Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050011, People's Republic of China.
FAU - Yang, Huichai
AU  - Yang H
AD  - Department of Pathology, the Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050011, People's Republic of China.
FAU - Sun, Xuemei
AU  - Sun X
AD  - Department of Pathology, the Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050011, People's Republic of China.
FAU - Liu, Yueping
AU  - Liu Y
AD  - Department of Pathology, the Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei, 050011, People's Republic of China.
LA  - eng
PT  - Case Reports
DEP - 20231117
PL  - New Zealand
TA  - Int Med Case Rep J
JT  - International medical case reports journal
JID - 101566269
PMC - PMC10663166
OTO - NOTNLM
OT  - diagnostic histopathology
OT  - lymphopoietic system
OT  - male breast
OT  - misdiagnosis
OT  - tumors
COIS- The authors declare that they have no competing interests.
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:43
PMCR- 2023/11/17
CRDT- 2023/11/29 14:46
PHST- 2023/08/12 00:00 [received]
PHST- 2023/11/02 00:00 [accepted]
PHST- 2023/11/29 18:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 14:46 [entrez]
PHST- 2023/11/17 00:00 [pmc-release]
AID - 434109 [pii]
AID - 10.2147/IMCRJ.S434109 [doi]
PST - epublish
SO  - Int Med Case Rep J. 2023 Nov 17;16:747-755. doi: 10.2147/IMCRJ.S434109. 
      eCollection 2023.