PMID- 38020592
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - Health-related quality of life after otologic surgical treatment for chronic 
      otitis media: systematic review.
PG  - 1268785
LID - 10.3389/fneur.2023.1268785 [doi]
LID - 1268785
AB  - OBJECTIVE: This systematic review aims to describe the impact of otologic surgery 
      as a treatment for chronic otitis media (COM) on the Health-Related Quality of 
      Life (HRQoL) of adult patients. METHODS: A literature search was performed in 
      PubMed, Scopus, Embase, and Web of Science until May 2023. Prospective studies 
      including adult patients with COM (cholesteatoma) who underwent canal wall up 
      mastoidectomy, canal wall down mastoidectomy, or tympanoplasty without 
      mastoidectomy, with pre- and postoperative HRQoL measurements, were considered 
      eligible. Questionnaire validation studies were excluded. The risk of bias and 
      study quality were evaluated with a Quality Assessment Tool (for before-after 
      studies with no control group). To assess the change in HRQoL, pre- and 
      postoperative HRQoL values and absolute changes were extracted, synthesized, and 
      presented in tables. Standardized mean differences (SMD) were calculated to 
      enhance comparisons. RESULTS: Of the 720 studies identified, 16 met the inclusion 
      criteria of this review. Different questionnaires were used throughout the 
      studies. The CES and COMOT-15 were used in five studies and the ZCMEI-21 and 
      COMQ-12 in three studies. All studies indicated statistically significant 
      improvement in HRQoL from pre- to postoperative, measured with disease-specific 
      HRQoL questionnaires. General HRQoL questionnaires did not show significant 
      improvement. Calculated SMDs ranged from 0.24 to 6.99. DISCUSSION AND CONCLUSION: 
      Included studies had low (n = 10) to high (n = 6) risk of bias and poor (n = 4), 
      fair (n = 7) or good (n = 5) study quality. Surgical treatment positively impacts 
      the HRQoL of adult COM patients with and without cholesteatoma. However, the 
      clinical relevance of the reported changes is unknown due to the lack of minimal 
      clinically important differences (MCID) or cut-off values in each questionnaire. 
      Therefore, further research regarding the MCIDs of each questionnaire is needed. 
      Future research should also report preoperative chief symptoms and indications 
      for surgery to improve individual patient counseling.
CI  - Copyright (c) 2023 Schouwenaar, Hellingman and Waterval.
FAU - Schouwenaar, Esther M M
AU  - Schouwenaar EMM
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht 
      University Medical Center, Maastricht, Netherlands.
FAU - Hellingman, Catharine A
AU  - Hellingman CA
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht 
      University Medical Center, Maastricht, Netherlands.
AD  - School for Mental Health and Neuroscience, Maastricht University Medical Center, 
      Maastricht, Netherlands.
FAU - Waterval, Jerome J
AU  - Waterval JJ
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht 
      University Medical Center, Maastricht, Netherlands.
AD  - School for Mental Health and Neuroscience, Maastricht University Medical Center, 
      Maastricht, Netherlands.
LA  - eng
PT  - Systematic Review
DEP - 20231102
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC10654635
OTO - NOTNLM
OT  - HRQoL
OT  - PROM
OT  - cholesteatoma
OT  - chronic otitis media
OT  - otologic surgery
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:43
PMCR- 2023/11/02
CRDT- 2023/11/29 14:47
PHST- 2023/07/28 00:00 [received]
PHST- 2023/10/02 00:00 [accepted]
PHST- 2023/11/29 18:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 14:47 [entrez]
PHST- 2023/11/02 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1268785 [doi]
PST - epublish
SO  - Front Neurol. 2023 Nov 2;14:1268785. doi: 10.3389/fneur.2023.1268785. eCollection 
      2023.