PMID- 38021453
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 2160-4150 (Print)
IS  - 2160-4150 (Electronic)
IS  - 2160-4150 (Linking)
VI  - 12
IP  - 4
DP  - 2023
TI  - Stem cells treatment in chronic ischemic heart disease: a narrative review.
PG  - 65-72
AB  - Chronic ischemic heart disease remains a major cause of morbidity and mortality 
      worldwide. Several trials have been performed to evaluate benefit of stem cells 
      transplantation to restore cardiac function in short- and long-term period after 
      myocardial infarction. This narrative review analyzes 24 clinical trials between 
      2005 and 2023 comprising 1824 patients with chronic heart disease without heart 
      failure. Percent increase in left ventricular ejection fraction (LVEF) and 
      decrease in New York Heart Association (NYHA) class at 6/12 months after stem 
      cells transplantation are reported. Thirteen trials showed a statistically 
      significant percent LVEF increase between 4% to 19% at 6/12 months after stem 
      cells transplantation (p values from 0.05 to 0.0001). No significant differences 
      in LVEF were observed between patients who underwent intracoronary or 
      intramyocardial transplantation. NYHA class decrease from severe to mild/moderate 
      was demonstrated in 10 trials reporting a significant LVEF increase. Patients 
      transplanted with bone marrow and peripheral blood CD133+ stem cells showed a 
      doubling of percentage LVEF increase in comparison to patients transplanted with 
      CD133- cells. This narrative review reports the conflicting results on this 
      topic. Multicenter randomized clinical trials should be performed to define the 
      efficacy of stem cells transplantation in chronic ischemic heart disease.
CI  - AJSC Copyright (c) 2023.
FAU - Carbone, Roberto G
AU  - Carbone RG
AD  - Department of Internal Medicine, University of Genoa Genoa, Italy.
FAU - Negrini, Simone
AU  - Negrini S
AD  - Department of Internal Medicine, University of Genoa Genoa, Italy.
FAU - Murdaca, Giuseppe
AU  - Murdaca G
AD  - Department of Internal Medicine, University of Genoa Genoa, Italy.
FAU - Fontana, Vincenzo
AU  - Fontana V
AD  - Clinical Epidemiology Unit, IRCCS San Martino Hospital Genoa, Italy.
FAU - Puppo, Francesco
AU  - Puppo F
AD  - Department of Internal Medicine, University of Genoa Genoa, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231020
PL  - United States
TA  - Am J Stem Cells
JT  - American journal of stem cells
JID - 101578936
PMC - PMC10658134
OTO - NOTNLM
OT  - New York Heart Association class
OT  - Stem cells
OT  - chronic ischemic heart disease
OT  - clinical trials
OT  - left ventricular ejection fraction
OT  - transplantation
COIS- None.
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:43
PMCR- 2023/10/20
CRDT- 2023/11/29 15:06
PHST- 2023/06/30 00:00 [received]
PHST- 2023/10/12 00:00 [accepted]
PHST- 2023/11/29 18:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 15:06 [entrez]
PHST- 2023/10/20 00:00 [pmc-release]
PST - epublish
SO  - Am J Stem Cells. 2023 Oct 20;12(4):65-72. eCollection 2023.