PMID- 38023618
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 1687-9627 (Print)
IS  - 1687-9635 (Electronic)
VI  - 2023
DP  - 2023
TI  - Cytomegalovirus Infection in Patient with Clear Cell Renal Cell Carcinoma.
PG  - 5560673
LID - 10.1155/2023/5560673 [doi]
LID - 5560673
AB  - INTRODUCTION: Cytomegalovirus (CMV) infection is a widespread condition that can 
      affect individuals of all ages. Most cases of CMV infection are mild and resolve 
      on their own. However, in immunocompromised individuals, such as post-transplant 
      patients or those with cancer, severe infections can occur. While there have been 
      several studies on CMV infection in post-transplant patients, there is limited 
      literature on CMV infection in cancer, particularly in kidney cancer. Case 
      Report. In this case report, we present the case of a 61-year-old man with clear 
      cell renal cell carcinoma who underwent targeted therapy with the receptor 
      tyrosine kinase (RTK) inhibitor lenvatinib and the mammalian target of rapamycin 
      (mTOR) inhibitor everolimus. The patient was hospitalized for 26 days and 
      admitted to the intensive care unit (ICU) due to shortness of breath, decreased 
      oxygen saturation, and irregular breathing. Cytomegalovirus polymerase chain 
      reaction (PCR) test results were positive. Given the high prevalence of CMV 
      infection in developing countries, it is likely that the patient had a 
      reactivation of CMV. As such, the patient was subsequently treated with 
      ganciclovir for 14 days and showed improvement in symptoms such as shortness of 
      breath, cough, fever, and increased oxygen saturation. Following recovery, the 
      patient received maintenance therapy with oral valganciclovir for 7 days. No 
      further symptoms appeared during subsequent cancer treatments. CONCLUSION: Cancer 
      patients who are undergoing treatment are at a higher risk for developing 
      opportunistic infections, which can result in morbidity and mortality. Therefore, 
      healthcare professionals should be aware of the possibility of CMV infection in 
      cancer patients and be prepared to diagnose and treat the infection, particularly 
      in areas where the prevalence of CMV infection is high.
CI  - Copyright (c) 2023 Ikhwan Rinaldi et al.
FAU - Rinaldi, Ikhwan
AU  - Rinaldi I
AUID- ORCID: 0000-0002-6872-8802
AD  - Division of Hematology and Medical Oncology, Department of Internal Medicine, 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia.
FAU - Muthalib, Abdul
AU  - Muthalib A
AD  - Division of Hematology and Medical Oncology, Department of Internal Medicine, 
      Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas 
      Indonesia, Jakarta, Indonesia.
FAU - Sutandar, Januar Widodo
AU  - Sutandar JW
AD  - Department of Internal Medicine, Gading Pluit Hospital, Jakarta, Indonesia.
FAU - Kuncoro, Hendro Adi
AU  - Kuncoro HA
AD  - Department of Cardiology, Gading Pluit Hospital, Jakarta, Indonesia.
FAU - Harsono, Bambang Irawan
AU  - Harsono BI
AD  - Department of Pulmonology, Gading Pluit Hospital, Jakarta, Indonesia.
FAU - Susanto, Nelly
AU  - Susanto N
AD  - Department of Radiology, Gading Pluit Hospital, Jakarta, Indonesia.
FAU - Setiawan, Tjondro
AU  - Setiawan T
AD  - Department of Radiology, Gading Pluit Hospital, Jakarta, Indonesia.
FAU - Winston, Kevin
AU  - Winston K
AUID- ORCID: 0000-0003-2667-1999
AD  - Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
FAU - Dewantara, Idham Rafly
AU  - Dewantara IR
AUID- ORCID: 0000-0002-2594-541X
AD  - Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
FAU - Amin, Ihya Fakhrurizal
AU  - Amin IF
AUID- ORCID: 0000-0002-2024-9650
AD  - Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
FAU - Shufiyani, Yuli Maulidiya
AU  - Shufiyani YM
AUID- ORCID: 0009-0005-9487-3527
AD  - Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
LA  - eng
PT  - Case Reports
DEP - 20231113
PL  - United States
TA  - Case Rep Med
JT  - Case reports in medicine
JID - 101512910
PMC - PMC10661874
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:43
PMCR- 2023/11/13
CRDT- 2023/11/29 15:51
PHST- 2023/01/19 00:00 [received]
PHST- 2023/08/08 00:00 [revised]
PHST- 2023/10/25 00:00 [accepted]
PHST- 2023/11/29 18:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 15:51 [entrez]
PHST- 2023/11/13 00:00 [pmc-release]
AID - 10.1155/2023/5560673 [doi]
PST - epublish
SO  - Case Rep Med. 2023 Nov 13;2023:5560673. doi: 10.1155/2023/5560673. eCollection 
      2023.