PMID- 3802441
OWN - NLM
STAT- MEDLINE
DCOM- 19870227
LR  - 20190623
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 75
IP  - 2
DP  - 1987 Feb
TI  - Monophasic action potential mapping in human subjects with normal 
      electrocardiograms: direct evidence for the genesis of the T wave.
PG  - 379-86
AB  - T wave concordance in the normal human electrocardiogram (ECG) generally is 
      explained by assuming opposite directions of ventricular depolarization and 
      repolarization; however, direct experimental evidence for this hypothesis is 
      lacking. We used a contact electrode catheter to record monophasic action 
      potentials (MAPs) from 54 left ventricular endocardial sites during cardiac 
      catheterization (seven patients) and a new contact electrode probe to record MAPs 
      from 23 epicardial sites during cardiac surgery (three patients). All patients 
      had normal left ventricular function and ECGs with concordant T waves. MAP 
      recordings during constant sinus rhythm or right atrial pacing were analyzed for 
      activation time (AT) = earliest QRS deflection to MAP upstroke, action potential 
      duration (APD) = MAP upstroke to 90% repolarization, and repolarization time (RT) 
      = AT plus APD. AT and APD varied by 32 and 64 msec, respectively, over the left 
      ventricular endocardium and by 55 and 73 msec, respectively, over the left 
      ventricular epicardium. On a regional basis, the diaphragmatic and apicoseptal 
      endocardium had the shortest AT and the longest APD, and the anteroapical and 
      posterolateral endocardium had the longest AT and the shortest APD (p less than 
      .05 to less than .0001). RT was less heterogeneous than APD, and no significant 
      transventricular gradients of RT were found. In percent of the simultaneously 
      recorded QT interval, epicardial RT ranged from 70.8 to 87.4 (mean 80.7 +/- 3.9) 
      and endocardial RT ranged from 80 to 97.8 (mean 87.1 +/- 4.4) (p less than 
      .001).(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Franz, M R
AU  - Franz MR
FAU - Bargheer, K
AU  - Bargheer K
FAU - Rafflenbeul, W
AU  - Rafflenbeul W
FAU - Haverich, A
AU  - Haverich A
FAU - Lichtlen, P R
AU  - Lichtlen PR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Action Potentials
MH  - Cardiac Catheterization
MH  - Cardiac Pacing, Artificial
MH  - *Electrocardiography
MH  - Female
MH  - Heart/*physiology
MH  - Heart Conduction System/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 1987/02/01 00:00
MHDA- 1987/02/01 00:01
CRDT- 1987/02/01 00:00
PHST- 1987/02/01 00:00 [pubmed]
PHST- 1987/02/01 00:01 [medline]
PHST- 1987/02/01 00:00 [entrez]
AID - 10.1161/01.cir.75.2.379 [doi]
PST - ppublish
SO  - Circulation. 1987 Feb;75(2):379-86. doi: 10.1161/01.cir.75.2.379.