PMID- 38024642
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 2688-6146 (Electronic)
IS  - 2688-6146 (Linking)
VI  - 4
IP  - 4
DP  - 2023 Nov
TI  - Heparin-induced hyperkalemia, can LMWH cause hyperkalemia? A systematic review.
PG  - 1110-1116
LID - 10.1002/jha2.801 [doi]
AB  - Hyperkalemia, an elevated blood potassium concentration exceeding 5.0 mEq/L, is 
      associated with adverse outcomes and is frequently observed in hospitalized 
      patients. Drug-induced hyperkalemia accounts for a significant proportion of 
      cases, with heparin, commonly used for venous thrombosis prevention, suspected to 
      contribute, though less recognized than other heparin-related side effects. Both 
      unfractionated heparin (UFH) and low molecular weight heparin (LMWH) have been 
      implicated in inducing hyperkalemia, primarily through the suppression of 
      aldosterone levels and modulation of angiotensin II receptors. This systematic 
      review examines the relationship between heparin, particularly LMWH, and 
      hyperkalemia. Thirteen studies involving 1407 patients were analyzed. Findings 
      indicated a lack of highquality evidence, with no significant increase in 
      potassium levels associated with LMWH use. LMWH did not exhibit a dose-response 
      relationship with hyperkalemia incidence. Additionally, mechanisms underlying the 
      hypothetical LMWHinduced hyperkalemia remained inconclusive. While this suggests 
      that LMWH is unlikely to be a primary cause of hyperkalemia, caution is 
      warranted, especially in patients with elevated baseline potassium levels.
CI  - (c) 2023 The Authors. eJHaem published by British Society for Haematology and John 
      Wiley & Sons Ltd.
FAU - Amdetsion, Gedion Yilma
AU  - Amdetsion GY
AUID- ORCID: 0000-0001-6088-941X
AD  - Internal Medicine Division Addis Ababa University Addis Ababa Ethiopia.
AD  - Trauma and Orthopaeics Division Barts Health NHS Trust London UK.
FAU - Gudeta, Aron
AU  - Gudeta A
AD  - Internal Medicine Division Addis Ababa University Addis Ababa Ethiopia.
FAU - Lumley, Guy
AU  - Lumley G
AD  - Trauma and Orthopaeics Division Barts Health NHS Trust London UK.
FAU - Sagoo, Harkiran
AU  - Sagoo H
AD  - Trauma and Orthopaeics Division Barts Health NHS Trust London UK.
FAU - Aliledhin, Ehab
AU  - Aliledhin E
AD  - Trauma and Orthopaeics Division Barts Health NHS Trust London UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231003
PL  - United States
TA  - EJHaem
JT  - EJHaem
JID - 101761942
PMC - PMC10660614
OTO - NOTNLM
OT  - HEPARIN
OT  - LMWH
OT  - enoxaparin
OT  - heparin induced hyperkalmeia
OT  - hyperkalemia
OT  - hypoaldosteronism
COIS- The authors have no conflict of interest to declare. All co-authors have seen and 
      agree with the contents of the manuscript, and there is no financial interest to 
      report.
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:43
PMCR- 2023/10/03
CRDT- 2023/11/29 16:13
PHST- 2023/09/12 00:00 [received]
PHST- 2023/09/16 00:00 [revised]
PHST- 2023/09/22 00:00 [accepted]
PHST- 2023/11/29 18:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 16:13 [entrez]
PHST- 2023/10/03 00:00 [pmc-release]
AID - JHA2801 [pii]
AID - 10.1002/jha2.801 [doi]
PST - epublish
SO  - EJHaem. 2023 Oct 3;4(4):1110-1116. doi: 10.1002/jha2.801. eCollection 2023 Nov.