PMID- 38025770
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 26
IP  - 12
DP  - 2023 Dec 15
TI  - CD4(+)LAG3(+)T cells are decreased in SSc-ILD and affect fibroblast mesenchymal 
      transition by TGF-beta3.
PG  - 108225
LID - 10.1016/j.isci.2023.108225 [doi]
LID - 108225
AB  - Pulmonary fibrosis frequently occurs in rheumatic conditions, particularly 
      systemic sclerosis-associated interstitial lung disease (SSc-ILD). The pathology 
      involves cell transformation into interstitial structures and collagen 
      accumulation. CD4(+)LAG3(+)T cells, known for immune inhibition, are relevant in 
      autoimmunity. This study investigates CD4(+)LAG3(+)T cells in SSc-ILD. Clinical 
      analysis revealed a correlation between CD4(+)LAG3(+)T cells and interleukin-6 
      (IL-6) and erythrocyte sedimentation rate (ESR). Using primary human lung 
      fibroblasts (pHLFs) and murine bone marrow-derived macrophages (BMDMs), we showed 
      that CD4(+)LAG3(+)T cells secreted TGF-beta3 inhibits TGF-beta1-induced mesenchymal 
      transformation, modulates cellular function, and reduces collagen release. In 
      mouse models, CD4(+)LAG3(+)T cells exhibited potential in alleviating 
      bleomycin-induced pulmonary fibrosis. This study emphasizes CD4(+)LAG3(+)T cells' 
      therapeutic promise against fibrosis and proposes their role as biomarkers.
CI  - (c) 2023 The Author(s).
FAU - Qin, Linmang
AU  - Qin L
AD  - Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital 
      (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 
      510080, China.
FAU - Lin, Haobo
AU  - Lin H
AD  - Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital 
      (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 
      510080, China.
FAU - Zhu, Fu
AU  - Zhu F
AD  - Liuzhou Worker's Hospital, Liuzhou 545007, China.
FAU - Wang, Jieying
AU  - Wang J
AD  - Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital 
      (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 
      510080, China.
FAU - Feng, Tianxiao
AU  - Feng T
AD  - Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital 
      (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 
      510080, China.
FAU - Xu, Ting
AU  - Xu T
AD  - Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital 
      (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 
      510080, China.
FAU - Zhang, Guangfeng
AU  - Zhang G
AD  - Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital 
      (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 
      510080, China.
FAU - Zhang, Xiao
AU  - Zhang X
AD  - Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital 
      (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 
      510080, China.
LA  - eng
PT  - Journal Article
DEP - 20231017
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC10661698
OTO - NOTNLM
OT  - Fibrosis
OT  - Health sciences
OT  - Rheumatology
COIS- The authors declare no competing interests.
EDAT- 2023/11/29 18:43
MHDA- 2023/11/29 18:44
PMCR- 2023/10/17
CRDT- 2023/11/29 16:36
PHST- 2023/05/08 00:00 [received]
PHST- 2023/09/04 00:00 [revised]
PHST- 2023/10/13 00:00 [accepted]
PHST- 2023/11/29 18:44 [medline]
PHST- 2023/11/29 18:43 [pubmed]
PHST- 2023/11/29 16:36 [entrez]
PHST- 2023/10/17 00:00 [pmc-release]
AID - S2589-0042(23)02302-7 [pii]
AID - 108225 [pii]
AID - 10.1016/j.isci.2023.108225 [doi]
PST - epublish
SO  - iScience. 2023 Oct 17;26(12):108225. doi: 10.1016/j.isci.2023.108225. eCollection 
      2023 Dec 15.