PMID- 38026114 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231201 IS - 2160-200X (Print) IS - 2160-200X (Electronic) IS - 2160-200X (Linking) VI - 13 IP - 5 DP - 2023 TI - Association of coronary plaque morphology with inflammatory biomarkers and target lesion revascularization in patients with chronic coronary syndrome: an optical coherence tomography study. PG - 309-319 AB - BACKGROUND: The characteristics of high-risk coronary atherosclerosis evaluated using optical coherence tomography (OCT) can have a prognostic role. Inflammatory biomarkers may be related to the severity of coronary artery disease. This study investigated the association of high-risk morphological features of coronary plaques on OCT with circulating levels of inflammatory biomarkers and target lesion revascularization (TLR). MATERIALS AND METHODS: We prospectively analyzed the data of 30 consecutive patients with chronic coronary syndrome who underwent percutaneous coronary intervention (PCI) using OCT. The levels of interleukin-6, tumor necrosis factor-alpha, high-sensitivity C-reactive protein, pentraxin 3, vascular endothelial growth factor, and monocyte chemoattractant protein-1 (MCP-1) were measured in plasma samples. Coronary plaque characteristics were scored quantitatively in the form of coronary plaque risk score (CPRS). The estimated high-risk plaque characteristics for TLR were plaque rupture, plaque erosion, calcified nodule, lipid-rich plaque, thin-cap fibroatheroma, cholesterol crystals, macrophage infiltration, microchannels, calcification angle >90 degrees , and microcalcifications. Each high-risk feature carries 1 point. Patients were defined as having a low CPRS (CPRS /=4). RESULTS: The primary outcome was TLR. TLR occurred in 6 (20%) patients within 15 months of PCI. High CPRS on OCT was directly correlated with TLR (P=0.029). In logistic regression analysis, CPRS was associated with TLR (odds ratio, 10.0; 95% confidence interval, 1.34-74.5). Serum MCP-1 level was significantly correlated with the CPRS (P=0.020). CONCLUSIONS: In patients with chronic coronary syndrome, CPRS may be a surrogate predictor of TLR. Serum MCP-1 may aid in the detection of high-risk coronary atherosclerosis. CI - AJCD Copyright (c) 2023. FAU - Saiin, Kohei AU - Saiin K AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Konishi, Takao AU - Konishi T AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Kazui, Sho AU - Kazui S AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Yasui, Yutaro AU - Yasui Y AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Takahashi, Yuki AU - Takahashi Y AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Naito, Seiichiro AU - Naito S AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Takenaka, Sakae AU - Takenaka S AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Mizuguchi, Yoshifumi AU - Mizuguchi Y AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Tada, Atsushi AU - Tada A AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Kobayashi, Yuta AU - Kobayashi Y AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Kato, Yoshiya AU - Kato Y AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Omote, Kazunori AU - Omote K AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Sato, Takuma AU - Sato T AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Kamiya, Kiwamu AU - Kamiya K AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Nagai, Toshiyuki AU - Nagai T AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. FAU - Tanaka, Shinya AU - Tanaka S AD - Department of Cancer Pathology, Faculty of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. AD - Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University Sapporo, Hokkaido, Japan. FAU - Anzai, Toshihisa AU - Anzai T AD - Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University Sapporo, Hokkaido, Japan. LA - eng PT - Journal Article DEP - 20231015 PL - United States TA - Am J Cardiovasc Dis JT - American journal of cardiovascular disease JID - 101569582 PMC - PMC10658051 OTO - NOTNLM OT - Chronic coronary syndrome OT - biomarker OT - optical coherence tomography OT - percutaneous coronary intervention OT - target lesion revascularization COIS- None. EDAT- 2023/11/29 18:42 MHDA- 2023/11/29 18:43 PMCR- 2023/10/15 CRDT- 2023/11/29 16:45 PHST- 2023/08/05 00:00 [received] PHST- 2023/10/07 00:00 [accepted] PHST- 2023/11/29 18:43 [medline] PHST- 2023/11/29 18:42 [pubmed] PHST- 2023/11/29 16:45 [entrez] PHST- 2023/10/15 00:00 [pmc-release] PST - epublish SO - Am J Cardiovasc Dis. 2023 Oct 15;13(5):309-319. eCollection 2023.