PMID- 38026240
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 1178-7031 (Print)
IS  - 1178-7031 (Electronic)
IS  - 1178-7031 (Linking)
VI  - 16
DP  - 2023
TI  - AMPK Signalling Pathway: A Potential Strategy for the Treatment of Heart Failure 
      with Chinese Medicine.
PG  - 5451-5464
LID - 10.2147/JIR.S441597 [doi]
AB  - Heart failure (HF) is a complex clinical syndrome that represents the advanced 
      stage of cardiovascular disease, characterized by systolic and diastolic 
      dysfunction of the heart. Despite continuous updates in HF treatment drugs, the 
      morbidity and mortality rates remain high, necessitating ongoing exploration for 
      new therapeutic targets. Adenosine monophosphate-activated protein kinase (AMPK) 
      is the serine/threonine protein kinase which responds to adenosine monophosphate 
      (AMP) levels.Activation of AMPK shifts cellular metabolic patterns from synthesis 
      to catabolism, enhancing energy metabolism in pathological conditions such as 
      inflammation, ischemia, obesity, and aging. Numerous studies have identified AMPK 
      as a vital target for HF treatment, with herbal monomers/extracts and compounds 
      affecting key signaling factors including rapamycin targeting protein (mTOR), 
      silencing regulator protein 1 (SIRT1), nuclear transcription factor E2-related 
      factor 2 (Nrf2), and nuclear transcription factor-kappaB (NF-kappaB) through regulation 
      of the AMPK signaling pathway.This modulation can achieve the effects of 
      improving metabolism, autophagy, reducing oxidative stress and inflammatory 
      response in the treatment of heart failure, with the advantages of 
      multi-targeting, comprehensive action and low toxicity.The modulation of the AMPK 
      pathway by Traditional Chinese Medicine (TCM) has emerged as a crucial research 
      direction for the prevention and treatment of HF, but a systematic summary and 
      generalization in this field is lacking. This article provides an overview of the 
      composition, regulation, and mechanism of the AMPK signaling pathway's influence 
      on HF, as well as a summary of current research on the regulation of the AMPK 
      pathway by TCM for HF prevention and treatment. The aim is to serve as a 
      reference for the diagnosis and treatment of HF using TCM and the development of 
      new drugs.
CI  - (c) 2023 Liu et al.
FAU - Liu, Changxing
AU  - Liu C
AD  - First Clinical Medical School, Heilongjiang University of Chinese Medicine, 
      Harbin, 150040, People's Republic of China.
FAU - Guo, Xinyi
AU  - Guo X
AD  - Clinical Medical School, Chengdu University of Traditional Chinese Medicine, 
      Chengdu, 610075, People's Republic of China.
FAU - Zhou, Yabin
AU  - Zhou Y
AD  - Department of Cardiology, The First Hospital of Heilongjiang University of 
      Chinese Medicine, Harbin, 150040, People's Republic of China.
FAU - Wang, He
AU  - Wang H
AD  - Department of Cardiology, The First Hospital of Heilongjiang University of 
      Chinese Medicine, Harbin, 150040, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231121
PL  - New Zealand
TA  - J Inflamm Res
JT  - Journal of inflammation research
JID - 101512684
PMC - PMC10676094
OTO - NOTNLM
OT  - AMPK signalling pathway
OT  - Chinese medicine
OT  - heart failure
OT  - mechanism of action
OT  - review
COIS- All the authors declare that they have no conflicts of interest.
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:43
PMCR- 2023/11/21
CRDT- 2023/11/29 16:47
PHST- 2023/10/11 00:00 [received]
PHST- 2023/11/10 00:00 [accepted]
PHST- 2023/11/29 18:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 16:47 [entrez]
PHST- 2023/11/21 00:00 [pmc-release]
AID - 441597 [pii]
AID - 10.2147/JIR.S441597 [doi]
PST - epublish
SO  - J Inflamm Res. 2023 Nov 21;16:5451-5464. doi: 10.2147/JIR.S441597. eCollection 
      2023.