PMID- 38028638
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 2667-100X (Electronic)
IS  - 2097-0250 (Print)
IS  - 2667-100X (Linking)
VI  - 3
IP  - 4
DP  - 2023 Oct 31
TI  - Venovenous extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 
      associated acute respiratory distress syndrome: A comparative cohort study in 
      China.
PG  - 326-334
LID - 10.1016/j.jointm.2023.07.003 [doi]
AB  - BACKGROUND: Venovenous extracorporeal membrane oxygenation (VV-ECMO) has been 
      demonstrated to be effective in treating patients with virus-induced acute 
      respiratory distress syndrome (ARDS). However, whether the management of ECMO is 
      different in treating H1N1 influenza and coronavirus disease 2019 
      (COVID-19)-associated ARDS patients remains unknown. METHODS: This is a 
      retrospective cohort study. We included 12 VV-ECMO-supported COVID-19 patients 
      admitted to The First Affiliated Hospital of Guangzhou Medical University, 
      Guangzhou Eighth People's Hospital, and Wuhan Union Hospital West Campus between 
      January 23 and March 31, 2020. We retrospectively included VV-ECMO-supported 
      patients with COVID-19 and H1N1 influenza-associated ARDS. Clinical 
      characteristics, respiratory mechanics including plateau pressure, driving 
      pressure, mechanical power, ventilatory ratio (VR) and lung compliance, and 
      outcomes were compared. RESULTS: Data from 25 patients with COVID-19 (n=12) and 
      H1N1 (n=13) associated ARDS who had received ECMO support were analyzed. COVID-19 
      patients were older than H1N1 influenza patients (P=0.004). The partial pressure 
      of arterial carbon dioxide (PaCO(2)) and VR before ECMO initiation were 
      significantly higher in COVID-19 patients than in H1N1 influenza patients 
      (P <0.001 and P=0.004, respectively). COVID-19 patients showed increased plateau 
      and driving pressure compared with H1N1 subjects (P=0.013 and P=0.018, 
      respectively). Patients with COVID-19 remained longer on ECMO support than did 
      H1N1 influenza patients (P=0.015). COVID-19 patients who required ECMO support 
      also had fewer intensive care unit and ventilator-free days than H1N1. 
      CONCLUSIONS: Compared with H1N1 influenza patients, COVID-19 patients were older 
      and presented with increased PaCO(2) and VR values before ECMO initiation. The 
      differences between ARDS patients with COVID-19 and influenza on VV-ECMO detailed 
      herein could be helpful for obtaining a better understanding of COVID-19 and for 
      better clinical management.
CI  - (c) 2023 The Authors.
FAU - Xu, Yonghao
AU  - Xu Y
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Xi, Yin
AU  - Xi Y
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
AD  - Department of Critical Care Medicine, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Cai, Shuijiang
AU  - Cai S
AD  - Department of Critical Care Medicine, Guangzhou Eighth People's Hospital, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Yu, Yuheng
AU  - Yu Y
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
AD  - Department of Critical Care Medicine, Guangzhou Eighth People's Hospital, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Chen, Sibei
AU  - Chen S
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Guan, Weijie
AU  - Guan W
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Liang, Weibo
AU  - Liang W
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Wu, Hongkai
AU  - Wu H
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - He, Weiqun
AU  - He W
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
AD  - Department of Critical Care Medicine, Guangzhou Eighth People's Hospital, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Deng, Xilong
AU  - Deng X
AD  - Department of Critical Care Medicine, Guangzhou Eighth People's Hospital, 
      Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Xu, Yuanda
AU  - Xu Y
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
AD  - Department of Critical Care Medicine, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Zhang, Rong
AU  - Zhang R
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Li, Manshu
AU  - Li M
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Pan, Jieyi
AU  - Pan J
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Liang, Zhenting
AU  - Liang Z
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Wang, Ya
AU  - Wang Y
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Kong, Shaofeng
AU  - Kong S
AD  - Department of Radiology, The First Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou, Guangdong, China.
FAU - Liu, Xiaoqing
AU  - Liu X
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
FAU - Lv, Zheng
AU  - Lv Z
AD  - Department of Critical Care Medicine, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Li, Yimin
AU  - Li Y
AD  - Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou 
      Medical University, State Key Laboratory of Respiratory Diseases, National 
      Clinical Research Center for Respiratory Disease, Guangzhou Institute of 
      Respiratory Health, Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20230913
PL  - China
TA  - J Intensive Med
JT  - Journal of intensive medicine
JID - 9918539389006676
PMC - PMC10658037
OTO - NOTNLM
OT  - Acute respiratory distress syndrome
OT  - Coronavirus disease 2019
OT  - H1N1 influenza
EDAT- 2023/11/29 18:41
MHDA- 2023/11/29 18:42
PMCR- 2023/09/13
CRDT- 2023/11/29 17:16
PHST- 2022/11/07 00:00 [received]
PHST- 2023/06/22 00:00 [revised]
PHST- 2023/07/07 00:00 [accepted]
PHST- 2023/11/29 18:42 [medline]
PHST- 2023/11/29 18:41 [pubmed]
PHST- 2023/11/29 17:16 [entrez]
PHST- 2023/09/13 00:00 [pmc-release]
AID - S2667-100X(23)00051-8 [pii]
AID - 10.1016/j.jointm.2023.07.003 [doi]
PST - epublish
SO  - J Intensive Med. 2023 Sep 13;3(4):326-334. doi: 10.1016/j.jointm.2023.07.003. 
      eCollection 2023 Oct 31.