PMID- 38028966
OWN - NLM
STAT- MEDLINE
DCOM- 20231201
LR  - 20240130
IS  - 1947-6108 (Electronic)
IS  - 1947-6094 (Print)
IS  - 1947-6108 (Linking)
VI  - 19
IP  - 5
DP  - 2023
TI  - Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease.
PG  - 47-57
LID - 10.14797/mdcvj.1294 [doi]
AB  - Peripheral arterial disease (PAD) represents a global health concern with a 
      rising prevalence attributed to factors such as obesity, diabetes, aging, and 
      smoking. Among patients with PAD, chronic limb-threatening ischemia (CLTI) is the 
      most severe manifestation, associated with substantial morbidity and mortality. 
      While revascularization remains the primary therapy for CLTI, not all patients 
      are candidates for such interventions, highlighting the need for alternative 
      approaches. Impaired angiogenesis, the growth of new blood vessels, is a central 
      feature of PAD, and despite decades of research, effective clinical treatments 
      remain elusive. Epigenetics, the study of heritable changes in gene expression, 
      has gained prominence in understanding PAD pathogenesis. Here, we explore the 
      role of epigenetic regulation in angiogenesis within the context of PAD, with a 
      focus on long non-coding RNAs and fibroblast-endothelial cell 
      transdifferentiation. Additionally, we discuss the interplay between metabolic 
      control and epigenetic regulation, providing insights into potential novel 
      therapeutic avenues for improving PAD treatments. This review aims to offer a 
      concise update on the application of epigenetics in angiogenesis and PAD 
      research, inspiring further investigations in this promising field.
CI  - Copyright: (c) 2023 The Author(s).
FAU - Malhi, Naseeb Kaur
AU  - Malhi NK
AUID- ORCID: 0000-0002-8981-2974
AD  - Beckman Research Institute City of Hope, Duarte, California, US.
FAU - Southerland, Kevin W
AU  - Southerland KW
AUID- ORCID: 0000-0002-0306-2130
AD  - Duke University Medical Center, Durham, North Carolina, US.
FAU - Lai, Li
AU  - Lai L
AUID- ORCID: 0000-0002-5731-2705
AD  - Houston Methodist Research Institute, Houston, Texas, US.
FAU - Chen, Zhen Bouman
AU  - Chen ZB
AUID- ORCID: 0000-0002-3291-1090
AD  - Beckman Research Institute City of Hope, Duarte, California, US.
LA  - eng
GR  - R01 HL145170/HL/NHLBI NIH HHS/United States
GR  - R56 HL169204/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20231116
PL  - United States
TA  - Methodist Debakey Cardiovasc J
JT  - Methodist DeBakey cardiovascular journal
JID - 101508600
SB  - IM
MH  - Humans
MH  - *Epigenesis, Genetic
MH  - *Peripheral Arterial Disease/genetics
MH  - Ischemia/genetics
PMC - PMC10655766
OTO - NOTNLM
OT  - angiogenesis
OT  - epigenetics
OT  - fibroblast-endothelial transdifferentiation
OT  - hindlimb ischemia (HLI)
OT  - long non-coding RNAs (lncRNAs)
OT  - peripheral arterial disease (PAD)
COIS- The authors have no competing interests to declare.
EDAT- 2023/11/29 18:42
MHDA- 2023/12/01 06:43
PMCR- 2023/11/16
CRDT- 2023/11/29 17:19
PHST- 2023/09/18 00:00 [received]
PHST- 2023/09/19 00:00 [accepted]
PHST- 2023/12/01 06:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 17:19 [entrez]
PHST- 2023/11/16 00:00 [pmc-release]
AID - 10.14797/mdcvj.1294 [doi]
PST - epublish
SO  - Methodist Debakey Cardiovasc J. 2023 Nov 16;19(5):47-57. doi: 
      10.14797/mdcvj.1294. eCollection 2023.