PMID- 38028987
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231201
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - The Correlation Between Thyroid Parameters and the Ratios of 
      Neutrophil/Lymphocyte and Platelet/Lymphocyte in Euthyroid Type 2 Diabetic 
      Patients.
PG  - 3763-3771
LID - 10.2147/DMSO.S431941 [doi]
AB  - PURPOSE: To investigate the thyroid parameters (thyroid stimulating hormone 
      (TSH), free triiodothyronine (FT3), and free thyroxine (FT4)) and their 
      relationship with inflammatory indicators (neutrophil/lymphocyte ratio (NLR) and 
      platelet/lymphocyte ratio (PLR)) in euthyroid individuals with type 2 diabetes 
      mellitus (T2DM). PATIENTS AND METHODS: Our study included 672 participants 
      diagnosed with T2DM, and 336 healthy individuals matched in terms of age and 
      gender. The laboratory inspection data of both type 2 diabetic patients and 
      healthy individuals as controls were analyzed separately. RESULTS: Compared with 
      a control group, the individuals with T2DM presented elevated levels of 
      inflammatory indicators, including white blood cells (WBC), neutrophils (NEUT), 
      neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). The 
      levels of TSH are elevated in the T2DM group, whereas the levels of FT3 or FT4 
      are reduced. TSH levels were significantly positively correlated with NLR or PLR, 
      while the levels of FT3 and FT4 were significantly negatively correlated with NLR 
      or PLR. Furthermore, thyroid parameters were correlated with gender, age, and 
      blood lipid metabolism. Multiple stepwise regression analysis identified gender, 
      NLR, PLR, and low-density lipoprotein (LDL) as significant contributing factors 
      for TSH. Additionally, gender, age, NLR, PLR, glycated hemoglobin A1c (HbA1c), 
      and LDL were identified as contributing factors for FT3, while PLR and total 
      cholesterol (TC) were identified as contributing factors for FT4. CONCLUSION: 
      Abnormal metabolism of thyroid parameters is associated with increased 
      inflammatory activity and impaired glycolipid metabolism in euthyroid type 2 
      diabetic patients.
CI  - (c) 2023 Chen et al.
FAU - Chen, Hui
AU  - Chen H
AUID- ORCID: 0000-0002-5419-7166
AD  - Department of Geriatrics, Taizhou People's Hospital Affiliated to Nanjing Medical 
      University, Taizhou, Jiangsu, People's Republic of China.
FAU - Ju, Jun-Qiang
AU  - Ju JQ
AD  - Department of Geriatrics, Taizhou People's Hospital Affiliated to Nanjing Medical 
      University, Taizhou, Jiangsu, People's Republic of China.
FAU - Qian, Xiao-Wu
AU  - Qian XW
AD  - Department of Geriatrics, Taizhou People's Hospital Affiliated to Nanjing Medical 
      University, Taizhou, Jiangsu, People's Republic of China.
FAU - Zhu, Zheng-Tai
AU  - Zhu ZT
AD  - Department of Geriatrics, Taizhou People's Hospital Affiliated to Nanjing Medical 
      University, Taizhou, Jiangsu, People's Republic of China.
FAU - Zhao, Chun-Zhi
AU  - Zhao CZ
AD  - Department of Geriatrics, Taizhou People's Hospital Affiliated to Nanjing Medical 
      University, Taizhou, Jiangsu, People's Republic of China.
FAU - Liu, Zhe
AU  - Liu Z
AD  - Department of Geriatrics, Taizhou People's Hospital Affiliated to Nanjing Medical 
      University, Taizhou, Jiangsu, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20231122
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10679513
OTO - NOTNLM
OT  - neutrophil/lymphocyte ratio
OT  - platelet/lymphocyte ratio
OT  - thyroid function
OT  - thyroid parameters
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest or personal relationships between the authors 
      that could have influenced the study.
EDAT- 2023/11/29 18:42
MHDA- 2023/11/29 18:43
PMCR- 2023/11/22
CRDT- 2023/11/29 17:20
PHST- 2023/09/02 00:00 [received]
PHST- 2023/11/08 00:00 [accepted]
PHST- 2023/11/29 18:43 [medline]
PHST- 2023/11/29 18:42 [pubmed]
PHST- 2023/11/29 17:20 [entrez]
PHST- 2023/11/22 00:00 [pmc-release]
AID - 431941 [pii]
AID - 10.2147/DMSO.S431941 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Nov 22;16:3763-3771. doi: 10.2147/DMSO.S431941. 
      eCollection 2023.